Investigating the mechanical behaviour of viscoelastic and brittle pharmaceutical excipients during tabletting: Revealing the unobvious potential of advanced compaction simulation
first_published_at:Dec. 13, 2025, midnight / date_published:Dec. 13, 2025
Papers
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13/12/2025 -
by
Daniel Zakowiecki,
Kirils Kukuls,
Krzysztof Cal,
Adrien Pelloux,
Valentyn Mohylyuk
**Background:** Compaction of formulation blends is a crucial step in pharmaceutical tablet manufacturing, especially when drug substances or functional excipients have limited flowability and tabletability.
**Objectives:** This study systematically investigated …