Application bulletins
Itraconazole (ITZ) is an antifungal drug commercially available as an oral solution or more commonly as 100 mg capsules. It has been reported that the bioavailability of the oral solution is only 55% [1]. One of the strategies to improve its solubility, and therefore its bioavailability, is to produce amorphous solid dispersions (ASDs) using the hot melt extrusion (HME) process. To produce tablets of these ITZ ASDs, with ITZ dose of 100 mg, it is necessary to increase the tablet weight to accommodate for other excipients which can facilitate disintegration and improve the bioavailability. Therefore, during formulation development it is important to consider quality attributes such as tablet size and shape as these would ease swallowing for patients along with acceptability of the product overall.
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