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Effect of compression process parameters on the physical properties and in vitro release mechanism of the press-coated nifedipine matrix sustained-release tablets

Papers - 01/11/2023 - by Yibin Guo, Peifu Xiao, Heyang Dong, Xueting Guo, Tian Yin, Yu Zhang, Haibing He, Yanjiao Wang, Jingxin Gou, Xing Tang

We aim to clarify the influence of compression process parameters on the physical properties and release kinetics of the dual-reservoir press-coated tablets (PCTs). The critical compression force from plastic deformation …

Indices for the brittleness of pharmaceutical tablets: A reassessment

Papers - 15/10/2023 - by Vincent Mazel, Pierre Tchoreloff

Brittleness is an important mechanical property. In the classical sense, a material is considered brittle if, during loading, it behaves elastically until failure. Nevertheless, it is also sometimes understood as …

Investigation of Dispersion Kinetics of Particulate Lubricants and their Effect on the Mechanical Strength of MCC Tablets

Papers - 26/09/2023 - by Daniel Puckhaber, Arno Kwade, Jan Henrik Finke

Tablets are commonly produced by internally adding particulate lubricants, which are known to possibly lower the mechanical strength of tablets. This reduction is caused by the coverage of matrix forming …

Effect of drug loading and relative humidity on the mechanical properties and tableting performance of Celecoxib–PVP/VA 64 amorphous solid dispersions

Papers - 25/09/2023 - by Frederick Osei-Yeboah, Changquan Calvin Sun

The mechanical properties of polymer-based amorphous solid dispersions (ASDs) are susceptible to changes in relative humidity (RH) conditions. The purpose of this study is to understand the impact of RH …

Leveraging a multivariate approach towards enhanced development of direct compression extended release tablets

Papers - 20/09/2023 - by A.S. Sousa, J. Serra, C. Estevens, R. Costa, A.J. Ribeiro

Extended release formulations play a crucial role in the pharmaceutical industry by maintaining steady plasma levels, reducing side effects, and improving therapeutic efficiency and compliance. One commonly used method to …

Multivariate data analysis for tableting perofrmance improvement at industrial scale.

Papers - 15/09/2023 - by Rita Mathe, Tibor Casian, Adriana Marina, Damaris Daiana Marusca, Ioan Tomuta

The objective of this work was to investigate the granule properties and processing conditions leading to capping and lamination phenomena occurred for a high drug load, wet granulated, film coated …

Excipients for Orally Disintegrating Tablets: Compaction Data Analysis and Study of Tableting Properties of Lubricated Co-processed Excipients

Papers - 04/09/2023 - by Mayowa Onayo, Yildiz Ozalp, Nailla Jiwa, Burcu Mesut, Sevgi Gungor

Selecting the most suitable co-processed excipient (CPE) is crucial in orally disintegrating tablets (ODTs) development. The study evaluated five CPE’s (Ludiflash®, Ludipress®, Ludipress® LCE, Pearlitol® 200 SD, and GalenIQ™721) that …

Effect of geometrical features on the capping behavior of biconvex tablets

Papers - 03/09/2023 - by Vincent Mazel, Cléo Garcia, Pierre Tchoreloff

Capping is a common industrial issue during the manufacturing of pharmaceutical tablets. It is influenced by both process and formulation parameters. In this work, a systematic study of the influence …

Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

Papers - 22/08/2023 - by Pankaj Bhatt, Vipin Kumar, Harsh Rastogi, Mayank Kumar Malik, Raghav Dixit, Sakshi Garg, Garima Kapoor, Suruchi Singh

The functional and tableting properties of barnyard millet starch (Echinochloa esculenta) were investigated in its native (alkali-treated) and chemically modified (phosphorylated) states. The grains were pulverized, soaked, and ground before …

Material-Sparing-Method-for-Dry-Granulation.original

Dry Granulation a material sparing method

Whitepaper - 01/08/2023 - by Bruno Villa

Granulation of pharmaceutical powder is often required to prevent segregation of the Active Pharmaceutical Ingredient (API) and/or to enhance the blend flowability, which is critical to ensure consistent tablet mass …

Simulation of roller compaction by combination of a compaction simulator and oscillating mill – A material sparing approach

Papers - 29/07/2023 - by Layla Hassan, René Jensen, Andrew Megarry, Lasse I Blaabjerg

This study investigates the feasibility of a compaction simulator and oscillating mill to mimic a roller compactor as a material sparing approach for process development. Microcrystalline cellulose and dicalcium phosphate …

Prediction of the Tensile Strength of Tablets Using LSTM Networks on Compression Profiles

Papers - 28/07/2023 - by Jill De Bisshop, Stefan Klinken

This publication's objective was to predict the tensile strength of tablets using an analysis of process data comprising compression pressure, sampling timestamps, and punch positions. A recurrent neuronal network, specifically …