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    Investigation on the effects of dwell time and loading strain rate on powder compaction and tablet properties: A compaction simulator study

    Investigation on the effects of dwell time and loading strain rate on powder compaction and tablet properties: A compaction simulator study

    Papers - 15/04/2025 - by MayLin T. Howard, Gerard R. Klinzing
    This study aims to separate the effects of dwell time and strain rate on tablet strength and cracking behavior. Using a hydraulic compaction simulator, we isolated dwell time and strain …
    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Papers - 05/04/2025 - by Layla Hassan, René Jensen, Zahra Sodal, Frederik Hellesøe Ørtoft, Lasse I. Blaabjerg, Umair Zafar
    It is commonly accepted that compaction simulators can mimic the uniaxial compression process of roller compactors. To align the simulation output with actual product relative density, a correction factor (Kp) …
    Data for "Accelerated medicines development using a digital formulator and a self-driving tableting DataFactory"

    Data for "Accelerated medicines development using a digital formulator and a self-driving tableting DataFactory"

    Papers - 31/03/2025 - by Mohammad Salehian, Faisal Abbas, Jonathan Moores, Jonathan Goldie, Alexandros Tsioutsios, Daniel Markl, Peter Hou, Victor Portela, Quentin Boulay, Roland Thiolliere, Ashley Stark, Jean-Jacques Schwartz, Jerome Guerin, Andrew G. P. Maloney, Alexandru A. Moldovan, Gavin K. Reynolds, Jérôme Mantanus, Catriona Clark, Paul Chapman, Alastair Florence
    The data and the code are provided in University of Strathclyde's GitLab repository under CC BY-NC license.
    Evaluation of Time-Dependent Deformation Behavior of Pharmaceutical Excipients in the Tableting Process

    Evaluation of time-dependent deformation behavior of pharmaceutical excipients in the tableting process

    Papers - 22/03/2025 - by Daisuke Mizunaga, Satoru Watano
    Tableting is a crucial process in pharmaceutical manufacturing that directly impacts product quality. Maintaining consistent quality from the research and development phase to full-scale production is essential during scale-up. In …
    Refining rotary press parameters for consistent tablet quality during product transfer

    Refining rotary press parameters for consistent tablet quality during product transfer

    Papers - 17/03/2025 - by Friederike Gütter, Moritz Rosch
    The goal of this study was to develop a fast and material-sparing method to optimize compaction and die filling processes for tablet manufacturing at high-speed production.
    Evolution of critical tablet attributes with temperature

    Evolution of critical tablet attributes with temperature

    Papers - 16/03/2025 - by Adrien Pelloux, Sixtine Caquant, Lucile Kubiak
    Goal: Determine the impact of the temperature on tablet attributes: appearance and hardness.
    In Vitro-In Vivo Correlation Of Amorphous Solid Dispersion Enabled Itraconazole Tablets

    In vitro-in vivo correlation of amorphous solid dispersion enabled itraconazole tablets

    Papers - 11/03/2025 - by Ana L. Coutinho, Asmita Adhikari, Samuel Krug, Maureen Kane, R. Gary Hollenbeck, Stephen W. Hoag, James E. Polli
    Purpose: This study addresses the lack of reports on in vitro-in vivo correlation (IVIVC) model development for immediate-release (IR) formulations and the limited investigation of formulation and process impacts on …
    Decoupling calibration and coarse-graining: Quest for a generalized parameter set for DEM simulation of pharmaceutical powder

    Decoupling calibration and coarse-graining: Quest for a generalized parameter set for DEM simulation of pharmaceutical powder

    Papers - 08/03/2025 - by Lokeshwar Mahto, Jayanta Chakraborty, Jitendra Kumar, Anurag Tripathi, Maitraye Sen, William Ketterhagen
    Calibrating particle contact model parameters is crucial for DEM simulations. However, there is currently no universal calibration technique that provides a generalized set of parameters for a given powder. Additionally, …
    Elucidating critical factors driving the tabletability flip phenomenon

    Elucidating critical factors driving the tabletability flip phenomenon

    Papers - 10/02/2025 - by Zijian Wang, Chenguang Wang, Changquan Calvin Sun
    Tabletability is a crucial property that determines a powder's ability to form tablets under applied stresses, typically illustrated by a plot of tablet tensile strength versus pressure. Tablet tensile strength …
    Impact of solid content on the bulk properties of lyophilized powders

    Impact of solid content on the bulk properties of lyophilized powders

    Papers - 10/02/2025 - by Zijian Wang, Sichen Song, Hongwei Zhang, Xiaohong Liu, Ronald A. Siegel, Changquan Calvin Sun, Chenguang Wang
    Interest in the oral delivery of biologics, often formulated via lyophilization, is growing rapidly. Lyophilization typically uses solutions with low solid content to optimize mass transfer and reduce drying time. …
    Decreased Crystal Plasticity by Solvation – the Case of Levofloxacin Acesulfame

    Decreased crystal plasticity by solvation – the case of levofloxacin acesulfame

    Papers - 06/02/2025 - by Pin-Syuan Huang, Changquan Calvin Sun
    A relationship between crystal packing efficiency and plasticity can be utilized to rank the plasticity of different crystal forms of a compound based on their structures. It was proposed that …
    A comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets

    A comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets

    Papers - 16/01/2025 - by A.S. Sousa, J. Serra, C. Estevens, R. Costa, A.J. Ribeiro
    The pharmaceutical industry is increasingly adopting innovative, data-driven tools to enhance, optimize, and accelerate the drug development process. Extended-release (ER) oral formulations offer numerous benefits, such as maintaining therapeutic drug …
    Salcaprozate-based ionic liquids for GLP-1 gastric delivery: A mechanistic understanding of in vivo performance

    Salcaprozate-based ionic liquids for GLP-1 gastric delivery: A mechanistic understanding of in vivo performance

    Papers - 10/01/2025 - by René Rebollo, Zhigao Niu, Lasse Blaabjerg, Damiano La Zara, Trine Juel, Henrik Duelund Pedersen, Vincent Andersson, Michaela Benova, Camilla Krogh, Raphaël Pons, Tobias Palle Holm, Per-Olof Wahlund, Li Fan, Zhuoran Wang, Adam Kennedy, Rune Ehrenreich Kuhre, Philip Christophersen, Pierre-Louis Bardonnet, Philip Jonas Sassene
    Peptide delivery through oral formulations requires high concentrations of permeation enhancers (PE) to facilitate absorption and often involves fasting between dosing and food intake. Developing formulations that enable rapid absorption …
    Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects

    Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects

    Papers - 05/01/2025 - by Davide D’Angelo, Eride Quarta, Gianluca Bazzoli, Annalisa Bianchera, Ruggero Bettini
    Aqueous solvent-based tablet coating is a well-established, environmentally sustainable alternative to coatings with organic solvents. However, this approach necessitates careful assessment of potential quality concerns, such as increased porosity and …
    Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

    Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

    Papers - 04/01/2025 - by Chenyu Wu, Zijian Wang, Xu Han, Xinyi Yu, Changquan Calvin Sun, Zhengzheng Zhou
    Diclofenac (DIC), a nonsteroidal anti-inflammatory drug, is characterized by poor tabletability and low water solubility. This study introduces a novel diclofenac-picolinamide cocrystal (DIC-PIC) aimed at improving both properties. The cocrystal …
    Using in-line measurement and statistical analyses to predict tablet properties compressed using a Styl’One compaction simulator: A high shear wet granulation study

    Using in-line measurement and statistical analyses to predict tablet properties compressed using a STYL’One compaction simulator: A high shear wet granulation study

    Papers - 16/12/2024 - by Issa Munu, Andrei L. Nicusan, Jason Crooks, Kendal Pitt, Christopher Windows-Yule, Andrew Ingram
    High shear wet granulation (HSWG) is a widely adopted method in tablet manufacturing due to its benefits, including improved flowability, enhanced powder handling, optimized process runtime, controlled size distribution, and …
    Efficient development of high drug loaded posaconazole tablets enabled by amorphous solid dispersion

    Efficient development of high drug loaded posaconazole tablets enabled by amorphous solid dispersion

    Papers - 04/12/2024 - by Tianyi Xiang, Sichen Song, Ronald A. Siegel, Changquan Calvin Sun
    Determining the maximum drug loading in amorphous solid dispersions (ASD) while ensuring sufficient physical stability and release performance is essential for developing ASD-enabled tablets for poorly soluble drugs. Recent research …
    Systematic investigation of the impact of screw elements in continuous wet granulation

    Systematic investigation of the impact of screw elements in continuous wet granulation

    Papers - 01/12/2024 - by Katharina Kiricenko, Robin Meier, Peter Kleinebudde
    Twin-screw wet granulation (TSG) is a continuous manufacturing method used to produce granules either as the final dosage form or as an intermediate step before tableting or capsule filling. Successful …
    Unveiling Swelling and Erosion Dynamics: Early Development Screening of Mirabegron Extended Release Tablets

    Unveiling swelling and erosion dynamics: early development screening of mirabegron extended release tablets

    Papers - 27/11/2024 - by Ana S. Sousa, J. Serra, C. Estevens, R. Costa, António J. Ribeiro
    The development of extended-release (ER) matrices has been widely studied, yet identifying the optimal drug release mechanism to achieve target release profiles remains a resource-intensive challenge in early formulation stages. …
    Effect of active material morphology on PTFE-fibrillation, powder characteristics and electrode properties in dry electrode coating processes

    Effect of active material morphology on PTFE-fibrillation, powder characteristics and electrode properties in dry electrode coating processes

    Papers - 25/11/2024 - by Marcella Horst, Franziska Beverborg, Lukas Bahlmann, Svenja Schreiber, Julius Gerk, Peter Michalowski, Arno Kwade
    This study explores how the particle morphology of active materials—platelet-like graphite, spherical highly porous LFP, and spherical NCM—significantly influences PTFE fibrillation during the mixing and calendering stages of a dry …