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    Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

    Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

    Papers - 22/04/2024 - by Natalia Veronica, Paul W. S. Heng, Celine V. Liew
    "Excipients are widely present in pharmaceutical products, often playing a crucial role in maintaining product quality. In the case of products containing drugs sensitive to moisture, the presence of moisture …
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    Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

    Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara
    Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …
    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Papers - 25/03/2024 - by Adwait Pradhan, Brian Phillips, Fengyuan Yang, Kapish Karan, Thomas Durig, Brian Haight, Charlie Martin, Feng Zhang
    Twin-screw melt granulation (TSMG) relies on both dispersive and distributive mixing at the kneading zone to facilitate granule growth, underscoring the pivotal role played by kneading elements in TSMG. Despite …
    Take-off sensor as a tool for sticking assessment during tablet development

    Take-off sensor as a tool for sticking assessment during tablet development

    Papers - 21/03/2024 - by Adrien Pelloux, Delphine Ach-Hubert, Sixtine Caquant
    More than 70% of candidate drugs have low solubility (BCS Class II and IV) (Nikolakakis et al. 2017). Making tablets with low solid fraction improves the dissolution rate (Van der …
    Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Papers - 18/03/2024 - by Zoltán Márk Horváth, Liga Lauberte, Valentyn Mohylyuk
    The aim of this study was to investigate the effect of PEG 8000 particle size and twin-screw melt granulation temperature on the properties of resultant MCC-CaHPO4 granules and their tablets.
    Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

    Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

    Papers - 13/03/2024 - by Donald J. Clancy, Gulenay Guner, Sayantan Chattoraj, Helen Yao, M. Connor Faith, Zahra Salahshoor, Kailey N. Martin, Ecevit Bilgili
    The objective of this study was to create a practical semi-mechanistic modeling framework for forecasting particle size changes during the wet bead milling of pharmaceutical nanosuspensions across various process conditions …
    A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery

    A strategy to optimize precompression pressure for tablet manufacturing based on in-die elastic recovery

    Papers - 07/03/2024 - by Gerrit Vreeman, Changquan Calvin Sun
    A strategy for optimizing precompression pressure, utilizing in-die elastic recovery, has been devised to effectively tackle tablet lamination caused by air entrapment. This approach involves intentionally intensifying the air entrapment …
    Study of compaction tools and parameters on critical quality attributes of high drug load minitablets

    Study of compaction tools and parameters on critical quality attributes of high drug load minitablets

    Papers - 05/03/2024 - by Shang Jun Loo, Cheng Yee Lim, Paul Wan Sia Heng, Lai Wah Chan
    Minitablets are created through the utilization of multiple die openings and multi-tip punches to enhance productivity. Typically, the total compaction force required is determined by multiplying the desired force per …
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    The Effect of Microcrystalline Cellulose–CaHPO4 Mixtures in Different Volume Ratios on the Compaction and Structural–Mechanical Properties of Tablets

    Papers - 05/03/2024 - by Valentyn Mohylyuk, Artūrs Paulausks, Oskars Radzins, Liga Lauberte
    The combination of microcrystalline cellulose (MCC), exhibiting plastic behavior, and calcium phosphate anhydrous (CaHPO4), known for its brittle characteristics during compaction, is widely favored in the pharmaceutical sector to achieve …
    A new insight into the mechanism of the tabletability flip phenomenon

    A new insight into the mechanism of the tabletability flip phenomenon

    Papers - 04/03/2024 - by Zijian Wang, Chenguang Wang, Yiwang Guo, Deepak Bahl, Alex Fok, Changquan Calvin Sun
    Tabletability arises from the dynamic interplay between interparticulate bonding area (BA) and bonding strength (BS), which is influenced by various factors such as the mechanical properties, size, shape, and surface …
    Tableting of coated multiparticulates: Influences of punch face configurations

    Tableting of coated multiparticulates: Influences of punch face configurations

    Papers - 01/03/2024 - by Daniel Robin Thio, Natalia Veronica, Paul Wan Sia Heng, Lai Wah Chan
    The impact of punch face design on multi-unit pellet system (MUPS) tablets was examined in this study. Drug-loaded pellets, coated with sustained-release polymers such as ethylcellulose or acrylic, were compacted …
    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Papers - 28/02/2024 - by Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
    Hydroxypropyl methylcellulose (HPMC) stands out as the favored hydrophilic matrix former in the production of controlled release formulations via continuous twin-screw wet granulation. However, previous observations have highlighted a challenge: …
    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Papers - 28/02/2024 - by Gerrit Vreeman, Danyingzi Guan, Yuncheng Cai, Qun Zhou, Changquan Calvin Sun
    Cocrystallization proves to be a potent technique for modifying the tableting performance of crystals by adjusting their mechanical attributes. This research delves into the cocrystallization of ligustrazine (LIG) with malonic …
    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    Papers - 22/02/2024 - by Dongyue Yu, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method proves effective in enhancing the solubility, dissolution, and bioavailability of poorly water-soluble medications. However, these forms are prone to transitioning into more thermodynamically stable, …
    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Papers - 20/02/2024 - by Zhixing Lin, Bian Cabello, Rajesh N. Davé
    Prior research has shown the advantages of applying dry coating to finely graded microcrystalline cellulose (MCC) to facilitate direct compression (DC), a preferred method in tablet manufacturing. This process enhances …
    Current State of Minitablet Product Design: A Review

    Current State of Minitablet Product Design: A Review

    Papers - 16/02/2024 - by Saikishore Meruva, Aditya B. Singaraju, Bhavani Prasad Vinjamuri, Robert Ternik, William C. Stagner
    Over the past two decades, there has been a remarkable surge in interest surrounding minitablets (MTs), particularly within the last ten years, as evidenced by the plethora of publications documented …
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    Use of Polyvinyl Alcohol as an effective Binder in Continuous Twin-Screw Granulation

    Papers - 01/02/2024 - by Gudrun Birk, Anja-Nadine Knüttel, Almut von der Brelie
    Granulation of powder blends is a frequently employed method in pharmaceutical formulations when there are issues with flowability, compactability, or uniformity in terms of the active pharmaceutical ingredient (API) content. …
    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
    Consolidation of Spray-Dried Amorphous Calcium Phosphate by Ultrafast Compression: Chemical and Structural Overview

    Consolidation of Spray-Dried Amorphous Calcium Phosphate by Ultrafast Compression: Chemical and Structural Overview

    Papers - 10/01/2024 - by Sylvain Le Grill, Christophe Drouet, Olivier Marsan, Yannick Coppel, Vincent Mazel, Marie-Claire Barthelemy, Fabien Brouillet
    A significant portion of research within the orthopedic and maxillofacial fields is devoted to advancing bioactive 3D scaffolds. This involves the exploration of highly resorbable compounds that can stimulate cell …
    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Papers - 07/01/2024 - by Nimmy Kumari, Parag Roy, Sukanta Roy, Chenguang Wang, Sourav Das, Noopur Pandey, Susanta Kumar Mondal, Anirbandeep Bose, Changquan Calvin Sun, Animesh Ghosh
    Pharmaceutical cocrystallization is widely applied to enhance the physicochemical attributes of Active Pharmaceutical Ingredients (APIs). However, the formulation of cocrystals with demonstrated clinical success is currently limited. The successful translation …