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    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Papers - 06/09/2024 - by Tong Liu, Jiahui Wang, Yupeng Feng, Haoran Wang, Yunlong Xu, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang
    The Theophylline and Salbutamol Bilayer Sustained-release Tablets (Yi Xi Qing®), produced using wet granulation, are prone to discoloration during long-term storage, and the manufacturing process is less consistent and more …
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    Twin-screw melt granulation with PEG 8000: Effect of binder particle size and processing temperature on the granule and tablet properties

    Papers - 01/09/2024 - by Zoltán Márk Horváth, Liga Petersone, Valentyn Mohylyuk
    Twin-screw melt granulation (TSMG) is a promising green technology for manufacturing solid dosage forms in pharmaceuticals and nutraceuticals. PEG 8000 is widely used as a TSMG binder. While the literature …
    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Papers - 15/08/2024 - by Dingeman L.H. Van Der Haven, René Jensen, Maria Mikoroni, Umair Zafar, James A. Elliott, Ioannis S. Fragkopoulos
    The magnitude of frictional forces during the ejection of porous pharmaceutical tablets is crucial in determining the likelihood of tabletting defects. In this study, we conduct a systematic comparison of …
    Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time

    Dwell time on tableting: dwell time according to force versus geometric dwell time

    Papers - 24/07/2024 - by Valentyn Mohylyuk
    Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can …
    A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction speeds

    A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction speeds

    Papers - 20/07/2024 - by Jingzhe Li, Yin-Chao Tseng, Shubhajit Paul
    This research explores the modeling of the pharmaceutical roller compaction process, emphasizing the use of the Johanson model and the effects of varying roll speeds between 1 and 15 RPM …
    The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer

    The increase in the plasticity of microcrystalline cellulose spheres’ when loaded with a plasticizer

    Papers - 16/07/2024 - by Artūrs Paulausks, Tetiana Kolisnyk, Valentyn Mohylyuk
    Compaction pressure can cause undesirable effects in drugs such as solid-state polymorphic transitions, fragmentation, loss of coated pellet integrity, and reduced viability and vitality of microorganisms. To mitigate these effects, …
    Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products

    Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products

    Papers - 14/07/2024 - by Keita Yaginuma, Kensaku Matsunami, Laure Descamps, Alexander Ryckaert, Thomas De Beer
    T-shaped partial least squares regression (T-PLSR) is an effective machine learning technique for developing formulations and manufacturing processes for new drug products. Building an accurate T-PLSR model requires experimental data …
    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Papers - 04/07/2024 - by Julie Auffray, Hassana Hsein, Nicolas Biteau, Christophe Velours, Thierry Noel, Pierre Tchoreloff
    Among the various pharmaceutical forms, tablets provide numerous advantages, including ease of administration, cost-effectiveness in production, and enhanced stability of biomolecules. Additionally, tablets facilitate alternative routes for local delivery of …
    Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical powder compaction

    Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical powder compaction

    Papers - 01/07/2024 - by Dingeman L.H. Van Der Haven, Maria Mikoroni, Andrew Megarry, Ioannis S. Fragkopoulos, James A. Elliott
    This text describes a set of numerical methods for predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across a full range of compositions. An …
    Exploring the relationship between bulk Young’s Modulus of materials and milling efficiency during wet bead milling of pharmaceutical compounds

    Exploring the relationship between bulk Young’s Modulus of materials and milling efficiency during wet bead milling of pharmaceutical compounds

    Papers - 21/06/2024 - by Zahra Salahshoor, Parind M. Desai, Sayantan Chattoraj, Stephanie Lam
    Wet bead milling (WBM) is a primary method for producing long-acting injectable (LAI) suspensions, where the particle size of an Active Pharmaceutical Ingredient (API) is reduced in a liquid vehicle …
    Analysis of the impact of material properties on tabletability by principal component analysis and partial least squares regression

    Analysis of the impact of material properties on tabletability by principal component analysis and partial least squares regression

    Papers - 21/06/2024 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    In this study, principal component analysis (PCA) and partial least squares regression (PLS) were used together to identify the key material descriptors influencing tabletability in direct compression and roller compaction. …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Papers - 04/06/2024 - by Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla
    This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, …
    Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

    Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

    Papers - 25/05/2024 - by Otilia Koo, Chandrakant Patel, Faranak Nikfar
    Foam granulation presents a relatively novel approach to wet granulation, where foamed binder solutions are introduced to powder mixtures in the mixer. This serves to mitigate issues of localized over-wetting …
    Selection of lubricant type and concentration for orodispersible tablets

    Selection of lubricant type and concentration for orodispersible tablets

    Papers - 25/05/2024 - by Audrey Yi Zheng, Mahn Teng Loh, Paul Wan Sia Heng, Lai Wah Chan
    Lubricants play a vital role in most tablet formulations by aiding powder flow, preventing adhesion to tableting tools, and facilitating tablet ejection. Although magnesium stearate (MgSt) is commonly used as …
    Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations

    Tableting behavior of freeze and spray-dried excipients in pharmaceutical formulations

    Papers - 10/05/2024 - by Charbel Madi, Hassana Hsein, Virginie Busignies, Pierre Tchoreloff, Vincent Mazel
    Liquid biopharmaceuticals often face stability challenges during storage, making their preservation a priority. Among the various drying techniques employed in the pharmaceutical industry to enhance stability, lyophilization stands out as …
    New Hydrophilic Matrix Tablets for the Controlled Released of Chlorzoxazone

    New hydrophilic matrix tablets for the controlled released of chlorzoxazone

    Papers - 09/05/2024 - by Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Alina Diana Panainte, Gladiola Tantaru
    The controlled release of active ingredients like chlorzoxazone from matrix tablets, utilizing Kollidon®SR and chitosan, relies on both the drug's solubility in the dissolution medium and the composition of the …
    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Modified roller compaction model to account for roll speed effect on powder compaction in dry granulation process

    Papers - 07/05/2024 - by Indu Muthancheri, Mario Rousselin, Anna Espinose, Nicolas Sanchez, Jean-Rene Authelin
    This study presents an enhancement to the roller compaction model originally proposed by [1], incorporating the impact of roll speed on powder compaction during the dry granulation process. The updated …
    Understanding the Roles of Excipients in Moisture Management in Solid Dosage Forms

    Understanding the roles of excipients in moisture management in solid dosage forms

    Papers - 22/04/2024 - by Natalia Veronica, Paul W. S. Heng, Celine V. Liew
    "Excipients are widely present in pharmaceutical products, often playing a crucial role in maintaining product quality. In the case of products containing drugs sensitive to moisture, the presence of moisture …
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    Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

    Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara
    Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …