Tablet lipid-based drug delivery through adsorption process: development and use of a stepwise methodology

Oct. 29, 2026, midnight - by Claudia Gama , Serigne Fallou Diouf , Jean Michel Girard , Cedric Miolane , Laure Giraud , Philippe Caisse

Remove from favorites

Add to favorites

This study aims to develop a methodology for selecting inert carriers to adsorb lipid-based formulations (LBFs), thereby optimizing the oral bioavailability of BCS Class II/IV APIs in tablet formulations. Specifically, a modified Selection and Development Matrix for Solid Liquid Adsorption (SeDEM-SLA) was utilized, evaluating the mechanical and flow properties of loaded carriers alongside biorelevant dissolution data.

Download PDF