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    Direct compression peptide tablets: insights into the importance of permeation enhancer processibility and peptide stability

    Direct compression peptide tablets: insights into the importance of permeation enhancer processibility and peptide stability

    Papers - 10/10/2025 - by A. Fagan, L.M. Bateman, M. O’Mahony, A.M. Crean, J.P. O’Shea
    Recent breakthroughs in oral peptide delivery have largely stemmed from the use of chemical permeation enhancers such as sodium caprate (C10) and salcaprozate sodium (SNAC). However, combining peptides with these …
    AI-based inline prediction of tablet properties for accelerating formulation development

    AI-based inline prediction of tablet properties for accelerating formulation development

    Papers - 07/10/2025 - by Nico Kühnel, Jan Streckenbach, Pierre Braun, Moritz Rosch, Friederike Gütter, David Dormagen, Tim Landgraf
    Development of solid oral dosage forms depends on timely knowledge of critical quality attributes (CQAs) such as tablet hardness, tensile strength, solid fraction, and tablet weight. These CQAs are traditionally …
    Discerning excipient functionality: Lubricants vs. anti-adherents

    Discerning excipient functionality: Lubricants vs. anti-adherents

    Papers - 01/10/2025 - by Tianyi Xiang, Changquan Calvin Sun
    Excipients play a critical role in tablet manufacturing, contributing to both formulation performance and process efficiency. Among them, lubricants and anti-adherents serve distinct functions, though these roles are often mistakenly …
    Formulation optimization of ritonavir tablets containing spray dried dispersion from HPMCAS-L or PVP-VA and comparative dissolution/permeation performance

    Formulation optimization of ritonavir tablets containing spray dried dispersion from HPMCAS-L or PVP-VA and comparative dissolution/permeation performance

    Papers - 25/09/2025 - by Ayse Nur Oktay, James E. Polli
    Tablets remain the most widely used oral dosage form, valued for their rapid production, cost efficiency, stability, and patient adherence. Amorphous solid dispersions (ASDs) are a proven strategy to enhance …
    Investigation of differences in mechanisms of die filling between a compaction simulator and a rotary press

    Investigation of differences in mechanisms of die filling between a compaction simulator and a rotary press

    Papers - 23/09/2025 - by Ben Kohlhaas, Jan Henrik Finke
    Die filling plays a decisive role in tableting, as it governs tablet weight, its variability, and also influences mechanical strength and defect risk. While numerous studies have explored die filling …
    An effort to enhance the clinical translatability of caprate-based tablet formulations in gastric peptide delivery

    An effort to enhance the clinical translatability of caprate-based tablet formulations in gastric peptide delivery

    Papers - 23/09/2025 - by Pierre-Louis Bardonnet, Zhigao Niu, Jenni Pessi, Maria Kazakou, Konstantinos Raptis, Reece McCabe, Anders Toftlev, René Rebollo, Zhuoran Wang, Li Fan, Nicolai Rytter Mortensen, Lars Bardtrum, Vincent Andersson, Per-Olof Wahlund, Mathias Norrman, Andrew James Benie, Jian Xiong Wu, Max Sauter, Damiano La Zara, Philip Christophersen, Philip Jonas Sassene
    Sodium caprate (C10) is one of the most extensively studied permeation enhancers for improving oral peptide uptake. Yet, its effectiveness in clinical settings may be compromised by the acidic environment …
    Drug loading mechanism of hollow hydroxyapatite microcapsules

    Drug loading mechanism of hollow hydroxyapatite microcapsules

    Papers - 01/09/2025 - by Jonas Kost, Nathalie Peyer, Jörg Huwyler, Maxim Puchkov
    Inorganic hydroxyapatite microcapsules represent an innovative platform for oral drug delivery, designed as novel excipients known as Template Inverted Particles (TIP). These microcapsules support the development of orally disintegrating tablets …
    Sustained-release tablets prepared by compression coating technology achieve similar drug release to osmotic pump tablets: Process parameters and in vitro-in vivo evaluation

    Sustained-release tablets prepared by compression coating technology achieve similar drug release to osmotic pump tablets: Process parameters and in vitro-in vivo evaluation

    Papers - 01/09/2025 - by Zhitao Cai, Bei Liu, Han Zeng, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Yanjiao Wang, Xing Tang
    Over the past decades, various controlled-release technologies have been developed to achieve consistent drug release rates in vivo. Among these, osmotic pumps are widely used in commercial formulations due to …
    Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance

    Impact of functional-related characteristics (FRCs) of crospovidone on tablet disintegration performance

    Papers - 18/06/2025 - by Firas El-Saleh, Hendrik Hübscher, Sergei Trofimov, Christian Muehlenfeld
    Crospovidone, a commonly used superdisintegrant, is available in two pharmacopeial grades: Type A (with a coarser particle size) and Type B (with finer particles). Variations in particle size between these …
    pTab – A personalized bilayer tablet

    pTab – A personalized bilayer tablet

    Papers - 10/06/2025 - by Florian Tiltscher, Friederike Gütter, Monika Buchholz, Sebastian Eichler, Pierre Braun, Moritz Rosch
    Standardized doses in tablets are suitable for most APIs and patient groups. However, there are many instances in which personalized medication enables huge benefits for the patients. Especially if the …
    Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms during compaction?

    Does tablet shape and height influence survival of fluidized bed-granulated living microorganisms during compaction?

    Papers - 01/06/2025 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    Developing effective probiotic formulations requires gentle processing to preserve the viability of probiotic microorganisms, which is crucial for their health benefits. Fluidized bed spray granulation followed by tablet compression has …
    Predicting the tabletability of binary powder mixtures from that of individual components

    Predicting the tabletability of binary powder mixtures from that of individual components

    Papers - 29/05/2025 - by Vedant Girish Bhagali, Gerrit Vreeman, Aakash Hasabnis, Changquan Calvin Sun
    Predicting the tabletability—defined as the relationship between tensile strength and compaction pressure—of powder mixtures based on the tabletability of pure components can significantly streamline the tablet formulation process, saving both …
    Influences_variation_compressed material_image

    Influences of variations of the amount of compressed material on compressibility, tabletability and compactability

    Papers - 10/05/2025 - by Anh Tuan Tran, Stefan Klinken-Uth
    Compression analysis plays a critical role in evaluating materials and optimizing processes in pharmaceutical tablet manufacturing. While previous studies have examined how various process parameters — such as compression speed …
    Investigation on the effects of dwell time and loading strain rate on powder compaction and tablet properties: A compaction simulator study

    Investigation on the effects of dwell time and loading strain rate on powder compaction and tablet properties: A compaction simulator study

    Papers - 15/04/2025 - by MayLin T. Howard, Gerard R. Klinzing
    This study aims to separate the effects of dwell time and strain rate on tablet strength and cracking behavior. Using a hydraulic compaction simulator, we isolated dwell time and strain …
    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Influence of material and process parameters on the correction factor Kp in roller compaction simulation

    Papers - 05/04/2025 - by Layla Hassan, René Jensen, Zahra Sodal, Frederik Hellesøe Ørtoft, Lasse I. Blaabjerg, Umair Zafar
    It is commonly accepted that compaction simulators can mimic the uniaxial compression process of roller compactors. To align the simulation output with actual product relative density, a correction factor (Kp) …
    Data for "Accelerated medicines development using a digital formulator and a self-driving tableting DataFactory"

    Data for "Accelerated medicines development using a digital formulator and a self-driving tableting DataFactory"

    Papers - 31/03/2025 - by Mohammad Salehian, Faisal Abbas, Jonathan Moores, Jonathan Goldie, Alexandros Tsioutsios, Daniel Markl, Peter Hou, Victor Portela, Quentin Boulay, Roland Thiolliere, Ashley Stark, Jean-Jacques Schwartz, Jerome Guerin, Andrew G. P. Maloney, Alexandru A. Moldovan, Gavin K. Reynolds, Jérôme Mantanus, Catriona Clark, Paul Chapman, Alastair Florence
    The data and the code are provided in University of Strathclyde's GitLab repository under CC BY-NC license.
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    Enable the development of dissolution models as a path to real-time release testing in a continuous manufacturing environment

    Papers - 24/03/2025 - by Sara Campelos Batista
    In a continuous manufacturing environment, ensuring product quality and compliance requires real-time monitoring and control strategies. Traditionally performed offline, the dissolution test remains a time- and resource-intensive process. This work …
    Evaluation of Time-Dependent Deformation Behavior of Pharmaceutical Excipients in the Tableting Process

    Evaluation of time-dependent deformation behavior of pharmaceutical excipients in the tableting process

    Papers - 22/03/2025 - by Daisuke Mizunaga, Satoru Watano
    Tableting is a crucial process in pharmaceutical manufacturing that directly impacts product quality. Maintaining consistent quality from the research and development phase to full-scale production is essential during scale-up. In …
    Refining rotary press parameters for consistent tablet quality during product transfer

    Refining rotary press parameters for consistent tablet quality during product transfer

    Papers - 17/03/2025 - by Friederike Gütter, Moritz Rosch
    The goal of this study was to develop a fast and material-sparing method to optimize compaction and die filling processes for tablet manufacturing at high-speed production.
    Evolution of critical tablet attributes with temperature

    Evolution of critical tablet attributes with temperature

    Papers - 16/03/2025 - by Adrien Pelloux, Sixtine Caquant, Lucile Kubiak
    Goal: Determine the impact of the temperature on tablet attributes: appearance and hardness.