Twin-Screw Melt Granulation with Mannitol: High-Drug-Loaded Immediate-Release Tablets of Caffeine
first_published_at:June 12, 2026, midnight / date_published:June 12, 2026
Papers
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12/06/2026 -
by
Elzbieta Maria Buczkowska,
Kirils Kukuls,
Zoltán Márk Horváth,
Alīna Jaroslava Frolova,
Līga Pētersone,
Suha Dadou,
Valentyn Mohylyuk
High drug-loaded immediate-release formulations can be produced using solvent-free, continuous melt granulation with a twin-screw extruder. However, commonly used high-molecular-weight, hydrophobic melt binders can result in weak tablets and negatively …