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    assorted single-layer tablets on grey background

    Mimicking dry granulation on the STYL'One Evo to improve flowability

    Bulletins - 16/04/2024 - by Sixtine Caquant, Adrien Pelloux
    Dry granulation is a commonly used process in the pharmaceutical industry. It provides several key advantages, including precise particle size control, improved flowability of powders, versatility in processing materials, increased …
    a qbd approach

    A QbD approach to shorten tablet development time

    Bulletins - 20/07/2023 - by Régis Cazes
    Reducing “time to market” is the ultimate goal for every pharmaceutical lab. Being the first on the market brings a competitive advantage for prescription, over-the-counter, or generic-drug manufacturers. Applying quality-by-design …
    tablet white

    Using the STYL'One Nano compaction simulator to characterise round and oblong itraconazole amorphous solid dispersions tablets

    Bulletins - 05/03/2023 - by Hetvi Triboandas, Mariana Bezerra, Walkiria Schlindwein
    Itraconazole (ITZ) is an antifungal drug commercially available as an oral solution or more commonly as 100 mg capsules. It has been reported that the bioavailability of the oral solution …
    design of experiment

    Design of Experiments (DoE) An essential tool to better understand tablet formulations

    Bulletins - 01/03/2023 - by Mariana Bezerra, Hetvi Triboandas, Walkiria Schlindwein
    This paper covers a brief overview of the steps for pharmaceutical product development under the quality by design (QbD) framework; introduces design of experiments (DoE) applied to formulation of tablets …
    compaction characterisation

    Compaction characterisation of piroxicam amorphous solid dispersions formulations

    Bulletins - 05/02/2023 - by Mariana Bezerra, Hetvi Triboandas, Walkiria Schlindwein
    Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs [1]. They are comprised of high molar mass polymer carriers that stabilise the active …
    iStock-181879520

    Sizing wet granulations reduce drying time

    Bulletins - 16/01/2023 -
    Pharmaceutical companies worldwide have been using the Comil® for removing lumps from pharmaceutical wet masses prior to the drying process. When blending active ingredients, binders and water or solvent in …
    iStock-1253545551

    Dry granulation sizing prior to tableting

    Bulletins - 08/01/2023 -
    A large international pharmaceutical manufacturer approached Quadro with an application to reduce the size of a small percentage of over-sized particles contained within a dry granulation formulation.
    tablet white powder

    Formulation development and compaction of itraconazole amorphous solid dispersions tablets using quality by design principles

    Bulletins - 02/01/2023 - by Hetvi Triboandas, Mariana Bezerra, Walkiria Schlindwein
    Itraconazole (ITZ), a BCS Class II drug exhibiting low solubility (1-4 ng/mL in water) requires formulation enhancement to achieve enhanced bioavailability. To tackle this problem amorphous solid dispersions (ASDS) of …
    no-image

    Comparative analysis of the tabletting process between single rotary tablet press and double rotary tablet press

    Bulletins - 31/12/2022 - by Iva Gacevska, Meri Davceva
    The aim of this study was to compare the tableting process of tablets on Fette 2090 and Fette 3090. The Fette 2090i and Fette 3090i are both multi-station tablet presses. …
    no-image

    Resolving tableting challenges and optimization of the tablet compression step of an immediate-release analgesic formulation

    Bulletins - 31/12/2022 - by Angela Mirchevska, Sonja Dimchevska, Kristina Angelovska, Packa Antovska
    The aim of this study was to optimize the tablet compression process of an immediate-release analgesic formulation and to resolve the tableting challenges that appeared during the process development.
    Capture2

    Dosage form design and patient compliance: exploring orally disintegrating tablets as a patient-centric solution

    Bulletins - 14/12/2022 - by Ralph Gosden
    Poor compliance with a medication regimen reduces treatment effectiveness for the patient and has a significant impact on overall healthcare costs. Some of the common factors influencing compliance are the …
    JRS

    Direct compression of probiotic tablets with PROSOLV® EASYtab Nutra

    Bulletins - 17/11/2022 -
    Although probiotics are mostly administered in the form of capsules, there are some advantages of tablets in terms of production effort, cost efficiency and stability of the probiotic bacteria. As …
    PROSOLV

    The performance of PROSOLV EASYtab SP in four medium-dose, direct compression formulations with morphologically challenging model APIs

    Bulletins - 28/07/2022 -
    In the present study, the performance of PROSOLV EASYtab SP was tested in four DC formulations with different model APIs. Each of selected APIs presented a particular challenge in terms …
    Radial die wall measurement

    Radial die wall pressure measurement

    Bulletins - 30/05/2022 - by Delphine Ach-Hubert, Adrien Pelloux
    During tablet development, people study ejection forces (Fej) in order to avoid tablet defects during tablet manufacturing. Some of those defects, like lamination and capping are said to be linked …
    capping

    Effect of precompresion on capping tendency

    Bulletins - 06/04/2022 - by Sixtine Caquant
    Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process …
    MEDELPHARM Science Lab powder angle of repose

    Assess the impact of your granulation process parameters with the STYL'One Evo

    Bulletins - 01/03/2022 - by Sixtine Caquant, Adrien Pelloux
    Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient …
    ribblets.original

    A fundamental step in your tablet development

    Bulletins - 01/09/2021 - by Adrien Pelloux
    Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and …
    Nano_on_table_Medelpharm logo

    Material characterization with a V-shape compression profile on STYL'One Nano

    Bulletins - 01/08/2021 - by Sixtine Caquant, Quentin Boulay
    In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet …
    Material characterization with extended dwell time - bulletin

    Material characterization with extended dwell time compression profile on STYL'One Nano

    Bulletins - 01/05/2021 - by Quentin Boulay, Sixtine Caquant
    During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design …
    Advantages of Mannitol in Pharmaceutical Granulation Processes - bulletin

    Advantages of mannitol in pharmaceutical granulation processes - a comparison of different polymorphic forms

    Bulletins - 01/09/2020 - by Hans-Leonhard Ohrem
    The success of a wet granulation process depends on use of an excipient with excellent binding and compaction properties. Mannitol is frequently used for this purpose in solid dosage formulations …