Complex molecules complex problems

April 15, 2025

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The article from Outsourced Pharma discusses the increasing challenges in manufacturing complex small molecules, particularly for emerging biotech companies lacking in-house capabilities. It highlights the necessity of partnering with experienced contract development and manufacturing organizations (CDMOs) to address issues such as difficult chemistry, lengthy synthetic routes, and poor solubility. The article emphasizes that as many drugs are on accelerated approval pathways, collaboration with CDMOs becomes crucial to efficiently navigate the complexities of modern drug development.