Application bulletins
Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs [1]. They are comprised of high molar mass polymer carriers that stabilise the active pharmaceutical ingredients (APIs) in their amorphous state.
The ASD used in this study has 16% piroxicam (PRX) and 84% polyvinylpyrrolidone-acetate (PVPVA) carrier. The polymer concentration, in this case, is high and it can cause poor tabletability and fail the disintegration target for immediate release [2-3]. We have conveniently used Kollitab™ DC 87 L (KTab) as a combined filler, binder, disintegrant and lubricant. KTab is a coprocessed excipient based on 87% of lactose monohydrate, 9% of Kollidon® CL-F (KCL-F), 3% of Kollicoat® IR and 1% of sodium stearyl fumarate. This material provides improved flow, good compaction and enhanced disintegration time [4].
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