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    Elucidating critical factors driving the tabletability flip phenomenon

    Elucidating critical factors driving the tabletability flip phenomenon

    Papers - 10/02/2025 - by Zijian Wang, Chenguang Wang, Changquan Calvin Sun
    Tabletability is a crucial property that determines a powder's ability to form tablets under applied stresses, typically illustrated by a plot of tablet tensile strength versus pressure. Tablet tensile strength …
    Impact of solid content on the bulk properties of lyophilized powders

    Impact of solid content on the bulk properties of lyophilized powders

    Papers - 10/02/2025 - by Zijian Wang, Sichen Song, Hongwei Zhang, Xiaohong Liu, Ronald A. Siegel, Changquan Calvin Sun, Chenguang Wang
    Interest in the oral delivery of biologics, often formulated via lyophilization, is growing rapidly. Lyophilization typically uses solutions with low solid content to optimize mass transfer and reduce drying time. …
    Decreased Crystal Plasticity by Solvation – the Case of Levofloxacin Acesulfame

    Decreased Crystal Plasticity by Solvation – the Case of Levofloxacin Acesulfame

    Papers - 06/02/2025 - by Pin-Syuan Huang, Changquan Calvin Sun
    A relationship between crystal packing efficiency and plasticity can be utilized to rank the plasticity of different crystal forms of a compound based on their structures. It was proposed that …
    A comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets

    A comparative study of two data-driven modeling approaches to predict drug release from ER matrix tablets

    Papers - 16/01/2025 - by A.S. Sousa, J. Serra, C. Estevens, R. Costa, A.J. Ribeiro
    The pharmaceutical industry is increasingly adopting innovative, data-driven tools to enhance, optimize, and accelerate the drug development process. Extended-release (ER) oral formulations offer numerous benefits, such as maintaining therapeutic drug …
    Salcaprozate-based ionic liquids for GLP-1 gastric delivery: A mechanistic understanding of in vivo performance

    Salcaprozate-based ionic liquids for GLP-1 gastric delivery: A mechanistic understanding of in vivo performance

    Papers - 10/01/2025 - by René Rebollo, Zhigao Niu, Lasse Blaabjerg, Damiano La Zara, Trine Juel, Henrik Duelund Pedersen, Vincent Andersson, Michaela Benova, Camilla Krogh, Raphaël Pons, Tobias Palle Holm, Per-Olof Wahlund, Li Fan, Zhuoran Wang, Adam Kennedy, Rune Ehrenreich Kuhre, Philip Christophersen, Pierre-Louis Bardonnet, Philip Jonas Sassene
    Peptide delivery through oral formulations requires high concentrations of permeation enhancers (PE) to facilitate absorption and often involves fasting between dosing and food intake. Developing formulations that enable rapid absorption …
    Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects

    Unveiling tablet structural changes: A micro computed tomography analysis of aqueous coating effects

    Papers - 05/01/2025 - by Davide D’Angelo, Eride Quarta, Gianluca Bazzoli, Annalisa Bianchera, Ruggero Bettini
    Aqueous solvent-based tablet coating is a well-established, environmentally sustainable alternative to coatings with organic solvents. However, this approach necessitates careful assessment of potential quality concerns, such as increased porosity and …
    Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

    Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

    Papers - 04/01/2025 - by Chenyu Wu, Zijian Wang, Xu Han, Xinyi Yu, Changquan Calvin Sun, Zhengzheng Zhou
    Diclofenac (DIC), a nonsteroidal anti-inflammatory drug, is characterized by poor tabletability and low water solubility. This study introduces a novel diclofenac-picolinamide cocrystal (DIC-PIC) aimed at improving both properties. The cocrystal …
    Using in-line measurement and statistical analyses to predict tablet properties compressed using a Styl’One compaction simulator: A high shear wet granulation study

    Using in-line measurement and statistical analyses to predict tablet properties compressed using a Styl’One compaction simulator: A high shear wet granulation study

    Papers - 16/12/2024 - by Issa Munu, Andrei L. Nicusan, Jason Crooks, Kendal Pitt, Christopher Windows-Yule, Andrew Ingram
    High shear wet granulation (HSWG) is a widely adopted method in tablet manufacturing due to its benefits, including improved flowability, enhanced powder handling, optimized process runtime, controlled size distribution, and …
    Efficient development of high drug loaded posaconazole tablets enabled by amorphous solid dispersion

    Efficient development of high drug loaded posaconazole tablets enabled by amorphous solid dispersion

    Papers - 04/12/2024 - by Tianyi Xiang, Sichen Song, Ronald A. Siegel, Changquan Calvin Sun
    Determining the maximum drug loading in amorphous solid dispersions (ASD) while ensuring sufficient physical stability and release performance is essential for developing ASD-enabled tablets for poorly soluble drugs. Recent research …
    Systematic investigation of the impact of screw elements in continuous wet granulation

    Systematic investigation of the impact of screw elements in continuous wet granulation

    Papers - 01/12/2024 - by Katharina Kiricenko, Robin Meier, Peter Kleinebudde
    Twin-screw wet granulation (TSG) is a continuous manufacturing method used to produce granules either as the final dosage form or as an intermediate step before tableting or capsule filling. Successful …
    Unveiling Swelling and Erosion Dynamics: Early Development Screening of Mirabegron Extended Release Tablets

    Unveiling Swelling and Erosion Dynamics: Early Development Screening of Mirabegron Extended Release Tablets

    Papers - 27/11/2024 - by Ana S. Sousa, J. Serra, C. Estevens, R. Costa, António J. Ribeiro
    The development of extended-release (ER) matrices has been widely studied, yet identifying the optimal drug release mechanism to achieve target release profiles remains a resource-intensive challenge in early formulation stages. …
    Effect of active material morphology on PTFE-fibrillation, powder characteristics and electrode properties in dry electrode coating processes

    Effect of active material morphology on PTFE-fibrillation, powder characteristics and electrode properties in dry electrode coating processes

    Papers - 25/11/2024 - by Marcella Horst, Franziska Beverborg, Lukas Bahlmann, Svenja Schreiber, Julius Gerk, Peter Michalowski, Arno Kwade
    This study explores how the particle morphology of active materials—platelet-like graphite, spherical highly porous LFP, and spherical NCM—significantly influences PTFE fibrillation during the mixing and calendering stages of a dry …
    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Papers - 18/11/2024 - by Karl Vorländer, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    The viability of probiotic microorganisms is critical for their health benefits and must be carefully preserved throughout the production of final dosage forms, such as tablets. This includes processes like …
    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Papers - 15/11/2024 - by Vincent Mazel, Pierre Tchoreloff
    Relaxation tests are commonly used in the pharmaceutical industry to evaluate the strain rate sensitivity of powders and tablets. In these tests, a constant strain is applied to the powder …
    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Papers - 05/11/2024 - by Natalia Veronica, Paul Wan Sia Heng, Celine Valeria Liew
    This research paper investigates the impact of different fatty acid compositions in magnesium stearate (MgSt), a common tablet lubricant, on tablet properties. The study focused on the significance of stearate …
    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    Papers - 28/10/2024 - by Yiwang Guo, Lizbeth Martinez, Arnesh Palanisamy, Bindhu Gururajan, Changquan Calvin Sun
    Ribbon porosity is essential to monitor in roller compaction. This study compares six porosity measurement methods—caliper, X-ray microtomography (µCT), near-infrared spectroscopy (NIR), laser triangulation, mercury intrusion porosimetry (MIP), and GeoPyc—using …
    Real-time prediction of dissolution profiles of coated oral dosage forms

    Real-time prediction of dissolution profiles of coated oral dosage forms

    Papers - 21/10/2024 - by Stephan Sacher, Elisabeth Fink, Carolina Alva, Jesús Alberto Afonso Urich, Aygün Doğan, Vanessa Herndler, Ioannis Koutsamanis, Varun Kushwah, Anna Peter, Sharareh Salar-Behzadi, Katrina Wilfling, Sandra Stranzinger, Manuel Zettl, Xin Feng, Maxwell Korang-Yeboah, Huiquan Wu, Johannes G. Khinast
    Optical coherence tomography (OCT) has become an in-line monitoring method for pharmaceutical coating processes based on a representative sample size. In this study, a method was developed to correlate coating …
    Effect of Liquid Load Level and Binder Type on the Tabletability of Mesoporous Silica Based Liquisolids

    Effect of Liquid Load Level and Binder Type on the Tabletability of Mesoporous Silica Based Liquisolids

    Papers - 21/10/2024 - by Jan Appelhaus, Kristina E. Steffens, Karl G. Wagner
    Mesoporous silica facilitates the conversion of liquids into solids due to its high capacity to load liquid or dissolved active ingredients, enhancing dissolution properties. However, compressing both unloaded and loaded …
    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Papers - 20/10/2024 - by James Stephens, Nitin Kumar Swarnakar, Ming Ji, Sandip Tiwari
    The aim of this study was to optimize the formulation and production process of pharmaceutical tablets using an integrated approach involving algorithm-based formulation tool (ZoomLab®) and a compaction simulator (STYL’One …
    Beam‐Generated Sample Evolution to Emphasize Spatial Inhomogeneities: The Example of HPO <sub>4</sub> <sup>2−</sup> ‐Containing Amorphous Calcium Phosphate

    Beam‐generated sample evolution to emphasize spatial inhomogeneities: The example of HPO_4_2 ‐ containing Amorphous Calcium Phosphate

    Papers - 19/09/2024 - by Sylvain Le Grill, Olivier Marsan, Christophe Drouet, Fabien Brouillet
    Amorphous calcium phosphates (ACPs) are a group of bioactive compounds with particular importance in bone regeneration. However, their inherent metastability prevents them from being processed into 3D shapes through conventional …