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    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Papers - 18/11/2024 - by Karl Vorländer, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    The viability of probiotic microorganisms is critical for their health benefits and must be carefully preserved throughout the production of final dosage forms, such as tablets. This includes processes like …
    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Papers - 15/11/2024 - by Vincent Mazel, Pierre Tchoreloff
    Relaxation tests are commonly used in the pharmaceutical industry to evaluate the strain rate sensitivity of powders and tablets. In these tests, a constant strain is applied to the powder …
    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Magnesium Stearate Fatty Acid Composition, Lubrication Performance and Tablet Properties

    Papers - 05/11/2024 - by Natalia Veronica, Paul Wan Sia Heng, Celine Valeria Liew
    This research paper investigates the impact of different fatty acid compositions in magnesium stearate (MgSt), a common tablet lubricant, on tablet properties. The study focused on the significance of stearate …
    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    Papers - 28/10/2024 - by Yiwang Guo, Lizbeth Martinez, Arnesh Palanisamy, Bindhu Gururajan, Changquan Calvin Sun
    Ribbon porosity is essential to monitor in roller compaction. This study compares six porosity measurement methods—caliper, X-ray microtomography (µCT), near-infrared spectroscopy (NIR), laser triangulation, mercury intrusion porosimetry (MIP), and GeoPyc—using …
    Real-time prediction of dissolution profiles of coated oral dosage forms

    Real-time prediction of dissolution profiles of coated oral dosage forms

    Papers - 21/10/2024 - by Stephan Sacher, Elisabeth Fink, Carolina Alva, Jesús Alberto Afonso Urich, Aygün Doğan, Vanessa Herndler, Ioannis Koutsamanis, Varun Kushwah, Anna Peter, Sharareh Salar-Behzadi, Katrina Wilfling, Sandra Stranzinger, Manuel Zettl, Xin Feng, Maxwell Korang-Yeboah, Huiquan Wu, Johannes G. Khinast
    Optical coherence tomography (OCT) has become an in-line monitoring method for pharmaceutical coating processes based on a representative sample size. In this study, a method was developed to correlate coating …
    Effect of Liquid Load Level and Binder Type on the Tabletability of Mesoporous Silica Based Liquisolids

    Effect of Liquid Load Level and Binder Type on the Tabletability of Mesoporous Silica Based Liquisolids

    Papers - 21/10/2024 - by Jan Appelhaus, Kristina E. Steffens, Karl G. Wagner
    Mesoporous silica facilitates the conversion of liquids into solids due to its high capacity to load liquid or dissolved active ingredients, enhancing dissolution properties. However, compressing both unloaded and loaded …
    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Papers - 20/10/2024 - by James Stephens, Nitin Kumar Swarnakar, Ming Ji, Sandip Tiwari
    The aim of this study was to optimize the formulation and production process of pharmaceutical tablets using an integrated approach involving algorithm-based formulation tool (ZoomLab®) and a compaction simulator (STYL’One …
    Beam‐Generated Sample Evolution to Emphasize Spatial Inhomogeneities: The Example of HPO <sub>4</sub> <sup>2−</sup> ‐Containing Amorphous Calcium Phosphate

    Beam‐generated sample evolution to emphasize spatial inhomogeneities: The example of HPO_4_2 ‐ containing Amorphous Calcium Phosphate

    Papers - 19/09/2024 - by Sylvain Le Grill, Olivier Marsan, Christophe Drouet, Fabien Brouillet
    Amorphous calcium phosphates (ACPs) are a group of bioactive compounds with particular importance in bone regeneration. However, their inherent metastability prevents them from being processed into 3D shapes through conventional …
    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Papers - 06/09/2024 - by Tong Liu, Jiahui Wang, Yupeng Feng, Haoran Wang, Yunlong Xu, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang
    The Theophylline and Salbutamol Bilayer Sustained-release Tablets (Yi Xi Qing®), produced using wet granulation, are prone to discoloration during long-term storage, and the manufacturing process is less consistent and more …
    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Papers - 15/08/2024 - by Dingeman L.H. Van Der Haven, René Jensen, Maria Mikoroni, Umair Zafar, James A. Elliott, Ioannis S. Fragkopoulos
    The magnitude of frictional forces during the ejection of porous pharmaceutical tablets is crucial in determining the likelihood of tabletting defects. In this study, we conduct a systematic comparison of …
    Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time

    Dwell time on tableting: dwell time according to force versus geometric dwell time

    Papers - 24/07/2024 - by Valentyn Mohylyuk
    Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can …
    A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction speeds

    A modified mechanistic approach for predicting ribbon solid fraction at different roller compaction speeds

    Papers - 20/07/2024 - by Jingzhe Li, Yin-Chao Tseng, Shubhajit Paul
    This research explores the modeling of the pharmaceutical roller compaction process, emphasizing the use of the Johanson model and the effects of varying roll speeds between 1 and 15 RPM …
    The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer

    The increase in the plasticity of microcrystalline cellulose spheres’ when loaded with a plasticizer

    Papers - 16/07/2024 - by Artūrs Paulausks, Tetiana Kolisnyk, Valentyn Mohylyuk
    Compaction pressure can cause undesirable effects in drugs such as solid-state polymorphic transitions, fragmentation, loss of coated pellet integrity, and reduced viability and vitality of microorganisms. To mitigate these effects, …
    Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products

    Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products

    Papers - 14/07/2024 - by Keita Yaginuma, Kensaku Matsunami, Laure Descamps, Alexander Ryckaert, Thomas De Beer
    T-shaped partial least squares regression (T-PLSR) is an effective machine learning technique for developing formulations and manufacturing processes for new drug products. Building an accurate T-PLSR model requires experimental data …
    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Papers - 04/07/2024 - by Julie Auffray, Hassana Hsein, Nicolas Biteau, Christophe Velours, Thierry Noel, Pierre Tchoreloff
    Among the various pharmaceutical forms, tablets provide numerous advantages, including ease of administration, cost-effectiveness in production, and enhanced stability of biomolecules. Additionally, tablets facilitate alternative routes for local delivery of …
    Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical powder compaction

    Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical powder compaction

    Papers - 01/07/2024 - by Dingeman L.H. Van Der Haven, Maria Mikoroni, Andrew Megarry, Ioannis S. Fragkopoulos, James A. Elliott
    This text describes a set of numerical methods for predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across a full range of compositions. An …
    Exploring the relationship between bulk Young’s Modulus of materials and milling efficiency during wet bead milling of pharmaceutical compounds

    Exploring the relationship between bulk Young’s Modulus of materials and milling efficiency during wet bead milling of pharmaceutical compounds

    Papers - 21/06/2024 - by Zahra Salahshoor, Parind M. Desai, Sayantan Chattoraj, Stephanie Lam
    Wet bead milling (WBM) is a primary method for producing long-acting injectable (LAI) suspensions, where the particle size of an Active Pharmaceutical Ingredient (API) is reduced in a liquid vehicle …
    Analysis of the impact of material properties on tabletability by principal component analysis and partial least squares regression

    Analysis of the impact of material properties on tabletability by principal component analysis and partial least squares regression

    Papers - 21/06/2024 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    In this study, principal component analysis (PCA) and partial least squares regression (PLS) were used together to identify the key material descriptors influencing tabletability in direct compression and roller compaction. …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Comprehensive Review of Modern Techniques of Granulation in Pharmaceutical Solid Dosage Forms

    Comprehensive review of modern techniques of granulation in pharmaceutical solid dosage forms

    Papers - 04/06/2024 - by Anil Kumar Vadaga, Sai Shashank Gudla, Gnanendra Sai Kumar Nareboina, Hymavathi Gubbala, Bhuvaneswari Golla
    This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, …