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    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    The impact of diluents on the compaction, dissolution, and physical stability of amorphous solid dispersion tablets

    Papers - 22/02/2024 - by Dongyue Yu, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method proves effective in enhancing the solubility, dissolution, and bioavailability of poorly water-soluble medications. However, these forms are prone to transitioning into more thermodynamically stable, …
    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Papers - 20/02/2024 - by Zhixing Lin, Bian Cabello, Rajesh N. Davé
    Prior research has shown the advantages of applying dry coating to finely graded microcrystalline cellulose (MCC) to facilitate direct compression (DC), a preferred method in tablet manufacturing. This process enhances …
    Current State of Minitablet Product Design: A Review

    Current state of minitablet product design: a review

    Papers - 16/02/2024 - by Saikishore Meruva, Aditya B. Singaraju, Bhavani Prasad Vinjamuri, Robert Ternik, William C. Stagner
    Over the past two decades, there has been a remarkable surge in interest surrounding minitablets (MTs), particularly within the last ten years, as evidenced by the plethora of publications documented …
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    Use of Polyvinyl Alcohol as an effective binder in continuous Twin-Screw Granulation

    Papers - 01/02/2024 - by Gudrun Birk, Anja-Nadine Knüttel, Almut von der Brelie
    Granulation of powder blends is a frequently employed method in pharmaceutical formulations when there are issues with flowability, compactability, or uniformity in terms of the active pharmaceutical ingredient (API) content. …
    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: compaction, dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
    Consolidation of Spray-Dried Amorphous Calcium Phosphate by Ultrafast Compression: Chemical and Structural Overview

    Consolidation of spray-dried amorphous Calcium Phosphate by ultrafast compression: chemical and structural overview

    Papers - 10/01/2024 - by Sylvain Le Grill, Christophe Drouet, Olivier Marsan, Yannick Coppel, Vincent Mazel, Marie-Claire Barthelemy, Fabien Brouillet
    A significant portion of research within the orthopedic and maxillofacial fields is devoted to advancing bioactive 3D scaffolds. This involves the exploration of highly resorbable compounds that can stimulate cell …
    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Papers - 07/01/2024 - by Nimmy Kumari, Parag Roy, Sukanta Roy, Chenguang Wang, Sourav Das, Noopur Pandey, Susanta Kumar Mondal, Anirbandeep Bose, Changquan Calvin Sun, Animesh Ghosh
    Pharmaceutical cocrystallization is widely applied to enhance the physicochemical attributes of Active Pharmaceutical Ingredients (APIs). However, the formulation of cocrystals with demonstrated clinical success is currently limited. The successful translation …
    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

    Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
    Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
    Elucidating the effect of salt incorporation in tablets on tablet disintegratability

    Elucidating the effect of salt incorporation in tablets on tablet disintegratability

    Papers - 04/01/2024 - by Audrey Yi Zheng, Yuan Wei Liau, Paul Wan Sia Heng, Lai Wah Chan
    The breakdown of tablets is vital for promoting drug release, and disintegrants are utilized in tablet formulations to enhance this process. This study aimed to investigate the influence of incorporating …
    Worsened punch sticking by external lubrication with magnesium stearate

    Worsened punch sticking by external lubrication with magnesium stearate

    Papers - 01/01/2024 - by Tianyi Xiang, Changquan Calvin Sun
    Applying magnesium stearate (MgSt) as an external lubricant to tooling is a widely used approach to prevent punch sticking during the compression of powders with a high tendency to stick, …
    Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations

    Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations

    Papers - 15/12/2023 - by Hanna Dorothea Grumann, Peter Kleinebudde
    The process of tableting involves transforming mechanical energy into thermal energy. This study assessed how temperature affects the tableting characteristics of formulations with varying compositions. A tableting machine equipped with …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Papers - 27/11/2023 - by Dario A. Dornbierer, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin Von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Erich Seifritz, Milan Scheidegger
    Recently, the plant medicine "ayahuasca" from the Amazon, which contains the psychedelic compound N,N-dimethyltryptamine (DMT) and various β-carboline alkaloids like harmine, has been proposed as having positive effects in individuals …
    Sticking Detection by Repeated Compactions on a Single Tablet

    Sticking detection by repeated compactions on a single tablet

    Papers - 21/11/2023 - by James Thomas, Phuong Bui, Antonios Zavaliangos
    Tablet sticking in the context of tablet manufacturing refers to the buildup of tablet material on the punch after multiple compaction cycles. The occurrence of sticking can impact tablet weight, …
    Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

    Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

    Papers - 21/11/2023 - by Ji Yeon Kim, Tae Hwan Kim, Eunbin Kim, Du Hyung Choi
    Objective: This study aimed to devise a developmental strategy for matrix tablets containing mirabegron, incorporating a quality by design approach that considers geometric properties such as gel strength, erosion rate, …
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    Effects of Granulated Lactose Characteristics and Lubricant Blending Conditions on Tablet Physical Properties in Direct Powder Compression

    Effects of granulated lactose characteristics and lubricant blending conditions on tablet physical properties in direct powder compression

    Papers - 15/11/2023 - by Shohei Nakamura, Nanami Ito, Ayumi Sakurada, Takatoshi Sakamoto
    Lactose serves as a widely used excipient for bulking, diluting, and shaping active pharmaceutical ingredients in tablet manufacturing. Specifically, granulated lactose (GL) designed for direct powder compression possesses unique characteristics …
    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Tableting properties of freeze-dried trehalose: physico-chemical and mechanical investigation

    Papers - 11/11/2023 - by Hassana Hsein, Charbel Madi, Vincent Mazel, Pierre Tchoreloff, Virginie Busignies
    The preferred method for enhancing the stability and storage conditions of biopharmaceutical products is freeze-drying. Typically, these freeze-dried products are designed for administration via the parenteral route. However, many parenterally …
    Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability

    Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability

    Papers - 09/11/2023 - by Audrey Yi Zheng, Wei Wei Huang, Li Ying Jolene Poon, Eunice Siying Wong, Paul Wan Sia Heng, Lai Wah Chan
    Objective Typically employed at low concentrations in tablets, superdisintegrants may exhibit an uneven spatial distribution within the tablet, leading to varied disintegration times. This study aimed to explore the impact …
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    Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content

    Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
    The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …