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    Powder_Explosion_Red_iStock-525212190

    Excipients used for solid dosage: innovations and challenges

    Newsfeeds - 14/08/2024 -
    *Excipients Used for Solid Dosage: Innovations and ChallengesSolid dosage forms are preferred in pharmaceuticals due to their ease of administration, accuracy, and cost-effectiveness. However, their effectiveness depends not just on …
    Image current trends and challenges influencing the oral solid dose market

    Current trends and challenges influencing the oral solid dose market

    Newsfeeds - 23/01/2024 -
    The article discusses current trends and challenges in the oral solid dose (OSD) market, focusing on the influence of patient-centric formulations and advancements in excipients. Key points include the importance …
    cdmo industry INCOG

    3 key trends shaping the CDMO industry in 2024

    Newsfeeds - 12/01/2024 -
    The article discusses three key trends shaping the Contract Development and Manufacturing Organization (CDMO) industry in 2024 and beyond:* Transition Towards Customer-Driven Manufacturing (CdMO)- The biopharma industry is evolving, and …
    reformulation by Biogrund

    The art of reformulation: tablet formulations redefined

    Newsfeeds - 06/11/2023 -
    The article discusses the significance of tablet reformulation in the pharmaceutical and dietary supplement industry. Reformulation is vital for improving efficacy, tolerability, and patent competitiveness. The process involves steps such …
    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    A novel approach to minimize loss of compactibility in a dry granulation process using superdisintegrants

    Papers - 07/08/2022 - by Maarten Jaspers, Timo P. Roelofs, Pauline H.M. Janssen, Robin Meier, Bastiaan H.J. Dickhoff
    Roller compaction for dry granulation is gaining popularity as a method for producing oral solid dosage forms. The process offers simplicity compared to wet granulation and operates inherently in a …
    How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression?

    How can single particle compression and nanoindentation contribute to the understanding of pharmaceutical powder compression?

    Papers - 01/08/2021 - by Isabell Wünsch, Stephanie Michel, Jan Henrik Finke, Edgar John, Michael Juhnke, Arno Kwade
    Understanding the deformation behavior of powder, including individual particle responses, is a critical factor in powder compaction, influencing powder compressibility and compactibility. Traditional approaches involve conducting powder compression experiments and …
    Functionality of disintegrants with different mechanisms after roll compaction

    Functionality of disintegrants with different mechanisms after roll compaction

    Papers - 01/06/2020 - by Sabrina Berkenkemper, Hannah Lou Keizer, Marc Lindenberg, Anikó Szepes, Peter Kleinebudde
    The objective of this study was to assess the functionality of two disintegrants, namely crospovidone and croscarmellose sodium, in tablet formulations processed through roll compaction followed by tableting. The investigation …
    Evolution of the die-wall pressure during the compression of biconvex tablets: experimental results and comparison with FEM simulation

    Evolution of the die-wall pressure during the compression of biconvex tablets: experimental results and comparison with FEM simulation

    Papers - 01/12/2015 - by Vincent Mazel, Harona Diarra, Virginie Busignies, Pierre Tchoreloff
    Capping is a common manufacturing issue observed in tablets, with a tendency to affect biconvex tablets more than their flat-faced counterparts. One contributing factor may be the generation of higher …
    Excipient–process interactions and their impact on tablet compaction and film coating

    Excipient–process interactions and their impact on tablet compaction and film coating

    Papers - 01/11/2014 - by Preetanshu Pandey, Dilbir S. Bindra, Shruti Gour, Jade Trinh, David Buckley, Sherif Badawy
    The aim of this investigation was to examine the influence of minor formulation components (sodium lauryl sulfate: SLS, and magnesium stearate: MgSt) and the manufacturing process on the compaction properties …
    no-image

    Dissolution enhancement and formulation of rapid-release lornoxicam mini-tablets

    Papers - 01/08/2014 - by Hesham M. Tawfeek, Imran Y. Saleem, Matthew Roberts
    The objective was to improve the dissolution of lornoxicam (LOR) and create mini-tablets with an optimized system to achieve a fast-release multi-particulate formulation. LOR systems were prepared through co-evaporation with …
    Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

    Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

    Papers - 01/06/2012 - by Vincent Mazel, Virginie Busignies, Harona Diarra, Pierre Tchoreloff
    The compaction process heavily relies on the elastic properties of pharmaceutical powders. Young's modulus (E) and Poisson's ratio (v) are key parameters representing the elastic behavior. However, as the powder …
    no-image

    Investigation into the impact of sub-populations of agglomerates on the particle size distribution and flow properties of conventional microcrystalline cellulose grades

    Papers - 01/10/2011 - by John F. Gamble, Wing-Sin Chiu, Mike Tobyn
    Microcrystalline cellulose (MCC) stands out as a highly adaptable tablet filler binder, widely employed in both granulation and direct compression processes. Previous research has revealed that MCC particle populations consist …
    Investigation into the degree of variability in the solid-state properties of common pharmaceutical excipients—anhydrous lactose

    Investigation into the degree of variability in the solid-state properties of common pharmaceutical excipients—anhydrous lactose

    Papers - 01/12/2010 - by John F. Gamble, Wing-Sin Chiu, Vivienne Gray, Helen Toale, Michael Tobyn, Yongmei Wu
    This paper discusses the variations in solid-state characteristics observed among different batches from three vendors of lactose anhydrous. The study explores both batch-to-batch and vendor-to-vendor differences and examines how these …
    Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products

    Evaluation of a rotary tablet press simulator as a tool for the characterization of compaction properties of pharmaceutical products

    Papers - 01/06/2010 - by F. Michaut, V. Busignies, C. Fouquereau, B. Huet de Barochez, B. Leclerc, P. Tchoreloff
    The Stylcam 100R, designed as a rotary press simulator to replicate speed profiles of rotary tablet presses, has undergone qualification by various laboratories. However, its suitability for investigating powder behavior …