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Scientific papers

Scientific papers

Explore a selection of scientific papers featuring research conducted with STYL’One Compaction Simulators. Discover how leading scientists and institutions use STYL’One technology to advance understanding in powder compression, tablet formulation development, and process innovation.

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    Merck formulation handbook - image

    Formulation handbook from Merck

    Newsfeed - 02/10/2025 -
    Formulating the perfect dosage form is no easy task. With so many techniques and excipients available, every decision made during development can influence the performance and success of the final …
    une-capsule-liquide-bleue-dans-une-grille-de-comprimes-blancs

    The challenges and opportunities of complex nutraceutical products

    Newsfeed - 25/07/2025 -
    The global nutraceuticals market is expanding rapidly, having reached $317.2 billion in 2023 and projected to grow at a CAGR of 9.6% through 2030, driven by a growing focus on …
    Advances in Pharmaceutical Product Development - image

    Advances in pharmaceutical product development

    Newsfeed - 21/07/2025 -
    The article on PharmaExcipients.com presents a detailed overview of the book Advances in Pharmaceutical Product Development, edited by Keerti Jain and Awesh K. Yadav.The book offers a comprehensive guide to …
    Predicting the tabletability of binary powder mixtures from that of individual components

    Predicting the tabletability of binary powder mixtures from that of individual components

    Papers - 29/05/2025 - by Vedant Girish Bhagali, Gerrit Vreeman, Aakash Hasabnis, Changquan Calvin Sun
    Predicting the tabletability—defined as the relationship between tensile strength and compaction pressure—of powder mixtures based on the tabletability of pure components can significantly streamline the tablet formulation process, saving both …
    Vitamins-as-excipients-in-pharmaceutical-products

    Vitamins as excipients in pharmaceutical products

    Newsfeed - 05/05/2025 -
    Vitamins are increasingly being explored as excipients in pharmaceutical formulations, offering more than just nutritional benefits. As reported by Pharma Excipients (April 2024), certain vitamins like Vitamin C and Vitamin …
    Yellow and white tablets on pink background

    Determination of ribbon solid fraction in roll compaction using ibuprofen DC100

    Newsfeed - 14/04/2025 -
    The study titled "Determination of Ribbon Solid Fraction in Roll Compaction using Ibuprofen DC100" focuses on developing a Process Analytical Technology (PAT) for in-line measurement of ribbon solid fraction during …
    close-up- pharma-powder-bowl-

    5 types of formulation excipients

    Newsfeed - 17/03/2025 -
    The article discusses the importance of buffer optimization in stabilizing early development biologic products. It highlights that excipients, which are additives to buffers, play a crucial role in enhancing the …
    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Newsfeed - 22/10/2024 -
    The article discusses the critical importance of tablet weight uniformity in the tablet manufacturing process, emphasizing its role in ensuring that each tablet consistently delivers the intended dosage of key …
    white-tablets-close-up

    Drug product formulation & process development: the must-have skills at a glance

    Newsfeed - 10/10/2024 -
    Drug product formulation and process development are critical yet often understated aspects of developing new drugs. Professionals in this field possess multidisciplinary skills, including organic chemistry, analytical development, solid-state characterization, …
    tablet white

    A recipe for success: mastering tableting requires understanding ingredient attributes

    Newsfeed - 12/09/2024 -
    The author discusses the importance of understanding ingredient attributes in the process of tablet manufacturing. It emphasizes that consistently producing high-quality tablets requires more than just creating a successful small-scale …
    Orally-disintegrating-tablets-offer-range-of-patient-benefits

    Adapting to an ageing world: formulation strategies to boost patient compliance

    Newsfeed - 11/09/2024 -
    The text discusses the challenges of medication compliance in older adults and how the pharmaceutical industry can address these through advanced drug formulations. With the global aging population rapidly increasing, …
    Image early solid form screening

    Early solid form screening guide drug substance through drug product development

    Newsfeed - 15/07/2024 -
    The article discusses the importance of early solid form screening in drug development. This process involves identifying the most stable and effective solid form of a drug substance early in …
    Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products

    Hybrid modeling of T-shaped partial least squares regression and transfer learning for formulation and manufacturing process development of new drug products

    Papers - 14/07/2024 - by Keita Yaginuma, Kensaku Matsunami, Laure Descamps, Alexander Ryckaert, Thomas De Beer
    T-shaped partial least squares regression (T-PLSR) is an effective machine learning technique for developing formulations and manufacturing processes for new drug products. Building an accurate T-PLSR model requires experimental data …
    Image - article Adare pharma solutions

    Formulation considerations for pediatric populations: finding the right dosage form for better adherence

    Newsfeed - 12/07/2024 -
    The text discusses the challenges and strategies for developing pediatric drug formulations to improve adherence and outcomes. It highlights the need for specialized technology platforms and expert partners to address …
    Webinar_Measuring static & kinetic friction_Starting slide

    Measuring static and kinetic friction in routine compaction cycles and their implication for formulation development

    Webinar Replays - 05/07/2024 - by Danny van der Haven, Quentin Boulay
    The ejection of pharmaceutical tablets from the die is a critical moment after compaction during which defects can be induced if frictional forces are too high. Various studies have looked …
    standard tablets on blue background

    Ebook: Twin-screw extrusion for pharmaceutical applications

    Newsfeed - 03/07/2024 -
    This compendium provides a comprehensive guide on how hot-melt extrusion (HME) can address common challenges in pharmaceutical development. It offers detailed guidance on all stages of the HME process, from …
    Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical powder compaction

    Multi-component mixing and demixing model for predictive finite element modelling of pharmaceutical powder compaction

    Papers - 01/07/2024 - by Dingeman L.H. Van Der Haven, Maria Mikoroni, Andrew Megarry, Ioannis S. Fragkopoulos, James A. Elliott
    This text describes a set of numerical methods for predictive finite element method (FEM) simulations of the compaction of multi-component pharmaceutical powder formulations across a full range of compositions. An …
    Webinar KIN 2 - Multilayer - Thumbnail slide

    Webinar series India - Multilayer tablets: from R&D formulation development to production scale-up

    Webinar Replays - 05/06/2024 - by Quentin Boulay, Bruno Leclercq, Pavan Porethi, Pravin Gawas
    Multilayer tablets are often the best solution to combine more than one API into a single dosage form. The main advantage is that the API contained in each layer of …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Posters - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …