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Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

Papers - 15/08/2024 - by Dingeman L.H. Van Der Haven, René Jensen, Maria Mikoroni, Umair Zafar, James A. Elliott, Ioannis S. Fragkopoulos

The magnitude of frictional forces during the ejection of porous pharmaceutical tablets is crucial in determining the likelihood of tabletting defects. In this study, we conduct a systematic comparison of …

Webinar_Measuring static & kinetic friction_Starting slide

Measuring static and kinetic friction in routine compaction cycles and their implication for formulation development

Webinar Replays - 05/07/2024 - by Danny van der Haven, Quentin Boulay

The ejection of pharmaceutical tablets from the die is a critical moment after compaction during which defects can be induced if frictional forces are too high. Various studies have looked …

Influence of the punch speed on the die wall/powder kinematic friction during tableting

Papers - 01/10/2019 - by Léo Desbois, Pierre Tchoreloff, Vincent Mazel

Investigating the impact of compaction speed on the final tablet properties poses a significant challenge during the scale-up of solid dosage forms. While strain rate sensitivity is typically attributed to …

Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

Papers - 01/01/2019 - by V. Mazel, H. Diarra, P. Tchoreloff

The final properties of tablets are predominantly determined during the compaction process by the development of stresses applied to the powder. Any parameter related to the process or product that …