Physicochemical changes and chemical degradation of gliclazide during twin-screw melt granulation
first_published_at:May 10, 2022, midnight / date_published:May 10, 2022
Papers
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10/05/2022 -
by
Tongzhou Liu,
Navpreet Kaur,
Beibei Chen,
Brian Phillips,
Shao-Yu Chang,
Fengyuan Yang,
Vivian Bi,
Thomas Durig,
Feng Zhang
Exploring the impact of the twin-screw melt granulation process on the chemical stability and process-induced physicochemical alterations of a drug, we utilized a miscible model formulation comprising 80% gliclazide (GLZ) …
