Comparison of hydroxypropylcellulose and hot-melt extrudable hypromellose in twin-screw melt granulation of metformin hydrochloride: effect of rheological properties of polymer on melt granulation and granule properties
first_published_at:Dec. 23, 2021, midnight / date_published:Dec. 23, 2021
Papers
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23/12/2021 -
by
Amol Batra,
Fengyuan Yang,
Michael Kogan,
Anthony Sosnowik,
Courtney Usher,
Eugene W. Oldham,
Ningyi Chen,
Kamaru Lawal,
Yunxia Bi,
Thomas Dürig
High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely recognized as extended-release polymers. While conventional high-molecular-weight HPMCs are preferred for extended-release applications, their use in twin-screw melt granulation is limited …
