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    Exploring the relationship between bulk Young’s Modulus of materials and milling efficiency during wet bead milling of pharmaceutical compounds

    Exploring the relationship between bulk Young’s Modulus of materials and milling efficiency during wet bead milling of pharmaceutical compounds

    Papers - 21/06/2024 - by Zahra Salahshoor, Parind M. Desai, Sayantan Chattoraj, Stephanie Lam
    Wet bead milling (WBM) is a primary method for producing long-acting injectable (LAI) suspensions, where the particle size of an Active Pharmaceutical Ingredient (API) is reduced in a liquid vehicle …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Papers - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Papers - 06/11/2023 - by Kaushalendra Chaturvedi, Pasaorn Pongkulapa, Xiaoyi Ding, Harsh S. Shah, San Kiang, Veeran Kadajji
    Coprocessing entails integrating multiple substances to enhance the physical, chemical, mechanical, and biopharmaceutical properties of a material. It stands as a promising technique in the pharmaceutical industry, supporting both drug …
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    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    Papers - 01/06/2023 -
    Radioactive substances released as nuclear power plant accident can contaminate soil in a wide area. Soil washing is used as decontamination technique for Cs-contaminated soil, which exhibits short processing time …
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    Evaluation of in-die compression data for a deeper understanding of altered excipient properties upon temperature rise

    Papers - 28/03/2023 - by Hanna Dorothea Grumann, Stefan Klinken, Peter Kleinebudde
    The thermodynamic analysis of tablet formation involves assessing both thermal and mechanical aspects during compression. This study aimed to examine variations in force–displacement data resulting from temperature increases, serving as …
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    Production challenges of tablets containing lipid excipients: Case study using cannabidiol as drug model

    Papers - 25/02/2023 -
    The aims of this study were, firstly, to select an optimal lipid solid dispersion of cannabidiol among different lipid excipients (Gelucire® 50/13, 48/16, 44/14 and Labrasol®) and inorganic carriers (colloidal …