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    Refining rotary press parameters for consistent tablet quality during product transfer

    Refining rotary press parameters for consistent tablet quality during product transfer

    Posters - 17/03/2025 - by Friederike Gütter, Moritz Rosch
    The goal of this study was to develop a fast and material-sparing method to optimize compaction and die filling processes for tablet manufacturing at high-speed production.
    Evolution of critical tablet attributes with temperature

    Evolution of critical tablet attributes with temperature

    Posters - 16/03/2025 - by Adrien Pelloux, Sixtine Caquant, Lucile Kubiak
    Goal: Determine the impact of the temperature on tablet attributes: appearance and hardness.
    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Posters - 20/10/2024 - by James Stephens, Nitin Kumar Swarnakar, Ming Ji, Sandip Tiwari
    The aim of this study was to optimize the formulation and production process of pharmaceutical tablets using an integrated approach involving algorithm-based formulation tool (ZoomLab®) and a compaction simulator (STYL’One …
    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Facilitating material-sparing dry granulation technical transfer through RoCo simulation of spray dried intermediate based formulations

    Posters - 04/06/2024 - by Allisson N. DuRoss, Kendall R. Pearson, Mark E. Waller, Hannah E. Worrest
    Problem Statement • Dry granulation (DG) demonstration batches consume large amounts of material and time • Spray dried intermediate (SDI) based tablets commonly require upstream dry granulation • Previous workflows …
    Take-off sensor as a tool for sticking assessment during tablet development

    Take-off sensor as a tool for sticking assessment during tablet development

    Posters - 21/03/2024 - by Adrien Pelloux, Delphine Ach-Hubert, Sixtine Caquant
    More than 70% of candidate drugs have low solubility (BCS Class II and IV) (Nikolakakis et al. 2017). Making tablets with low solid fraction improves the dissolution rate (Van der …
    Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Posters - 18/03/2024 - by Zoltán Márk Horváth, Liga Lauberte, Valentyn Mohylyuk
    The aim of this study was to investigate the effect of PEG 8000 particle size and twin-screw melt granulation temperature on the properties of resultant MCC-CaHPO4 granules and their tablets.
    Swift Single Step Scale up from Compaction Simulator to Production Rotary Press

    Swift single step scale-up from compaction simulator to production rotary press

    Posters - 21/03/2023 - by Moritz Rosch, Friederike Gütter
    The scale up process of tablets can be influenced by many factors that can occur during process development. The development can be highly catalyzed by compaction simulators, which allow for …
    Effect of Die Taper and Precompression on Air Entrapment during Tablet Compression

    Effect of die taper and precompression on air entrapment during tablet compression

    Posters - 03/11/2022 - by Gerrit Vreeman, Mehrdad Kheiripour Langroudi, Bhavesh Barot, Cletus Nunes, Rahul Manek, Yai Sartnurak, Changquan Calvin Sun
    During tablet compression, the presence of trapped air can significantly compromise both the visual appeal and mechanical characteristics of the tablet. Factors such as low-clearance tooling, elevated powder plasticity, and …
    Air entrapment during tablet compression – diagnosis and impact on tableting performance assessed with a compaction simulator

    Air entrapment during tablet compression – diagnosis and impact on tableting performance assessed with a compaction simulator

    Posters - 02/11/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    The occurrence of air entrapment during tablet compression has the potential to result in noteworthy defects in the tablets. Materials characterized by high plasticity and low bulk density are particularly …
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    A powder tabletability equation

    Posters - 01/11/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    A mathematical expression delineating the relationship between the tensile strength of tablets and compaction pressure was formulated using the equations initially suggested by Ryshkewitch and Kuentz-Leuenberger. This equation was applied …
    Development of an automated microscale manufacturing system for oral solid dosage forms

    Development of an automated microscale manufacturing system for oral solid dosage forms

    Posters - 20/06/2022 - by J Moores, F Abbas, M Salehian, D Markl, C Macleod, S G Pierce
    Platform II employs artificial intelligence (AI) to establish an autonomous workflow for the manufacturing and testing of drug products. It achieves this by identifying critical material attributes (CMAs) and their …
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    AI-assisted optimization of oral solid dosage form development

    Posters - 20/06/2022 - by M Salehian, J Moores, F Abbas, D Markl
    Platform II employs artificial intelligence (AI) to establish an autonomous workflow for the manufacturing and testing of drug products. It achieves this by identifying critical material attributes (CMAs) and their …