MEDELPHARM to present on temperature effects in tablet manufacturing
Adrien Pelloux, Application Lab Manager at MEDELPHARM, will deliver a presentation titled: "Impact of temperature on tablet critical quality attributes."
In this talk, Adrien will demonstrate how temperature rise — up to 60°C — on high-speed rotary presses can significantly affect tablet performance. Using the heated die system of the STYL’One Evo Compaction Simulator, he will highlight the impact of temperature on sticking, compression pressure, and overall tablet robustness.
Presentation highlights:
- Testing at 20°C and 50°C on customer formulations using real production tooling
- Lower pressure needed to achieve 2–3 MPa strength at 50°C
- Intense sticking observed after only 30 tablets at 50°C vs. none after 300 at 20°C
Key insights:
Temperature should be treated as a critical process variable early in development, serving as a valuable stress test to select more robust formulations and reduce time to market.
KORSCH to unveil poster on personalized solid dosage forms
Dr. Moritz Rosch, Process Specialist at KORSCH AG, will present a poster - pTab - A personalized bilayer tablet - on the development of personalized bilayer tablets, introducing a novel method for dose-adjustable tablets without changing size or form.
Key findings:
A personalized tablet was developed successfully covering the desired dose range for ibuprofen from 50 mg – 350 mg. By applying customized die feeding cycles and a custom 3D printed feeding wheel, the powder densities in the die were controlled very precisely. Consequently, a precise correlation of volumetric dosing and ibuprofen content was established.
This pTab concept offers a practical, scalable alternative to 3D printing — ideal for hospital pharmacy and individualized therapies, without the risks of heat or moisture degradation.
STYL’One Compaction Simulators featured in leading research presentations
Beyond their own contributions, MEDELPHARM and KORSCH technologies will be featured in multiple customer and academic presentations, emphasizing the widespread impact of the STYL’One Evo and STYL'One Nano across the global pharmaceutical landscape.
Highlighted sessions:
- Vincent Mazel (University of Bordeaux): Comparing compaction simulator and rotary presses at the compaction stage : some ideas about the “hidden” challenges in compaction simulation
- Changquan Calvin Sun (University of Minnesota): Frontiers in powder compaction research
- Dave Miller (AustinPx): Development of a high-drug load, functionally coated pediatric mini-tablet formulation using the STYL’One Nano Compaction Simulator
- Hamad Haider (Serán Bioscience): Bridging bench scale to pilot scale in dry granulation using compaction simulator with model based approach
Accelerating the future of tablet development
At CSF 2025, MEDELPHARM and KORSCH will once again demonstrate their commitment to driving innovation in tablet development — from solving real-world manufacturing challenges to pioneering personalized medicine.
The STYL’One Evo and Nano compaction simulators continue to be essential in bridging formulation development and production reality, empowering teams to deliver safe, effective, and patient-centric tablets faster than ever.
