Spray dried lubricants offering enhanced flowability

July 31, 2025

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The article "Spray Dried Lubricants Offering Enhanced Flowability" discusses the development and evaluation of novel spray-dried lubricants designed to improve the flowability of tablet formulations, especially in continuous manufacturing processes.

The research compared the performance of developmental spray-dried lubricants against standard lubricants in terms of flowability, lubrication efficiency, and tablet hardness.

Various excipients were used in the study, including sodium stearyl fumarate, microcrystalline cellulose, carboxymethyl cellulose sodium, calcium hydrogen phosphate dihydrate, and spray-dried lubricants based on magnesium stearate and sodium stearyl fumarate.

Powder characteristics such as bulk density, angle of repose, and flowability were assessed. Tablet formulations were prepared, and parameters like tablet hardness and disintegration were measured to evaluate lubricant performance.

The developmental spray-dried lubricants demonstrated superior flowability compared to standard lubricants. This improved flowability is critical for continuous manufacturing processes, where consistent powder flow ensures efficient tablet production.

Overall, the study highlights the importance of selecting appropriate lubricants to optimize pharmaceutical tablet manufacturing, ensuring consistent quality and process efficiency.