Tablet manufacturing technologies for solid drug formulation

September 16, 2025

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This article examines core tablet manufacturing technologies used in modern oral solid dosage production, emphasizing the roles of key formulation and process steps. It highlights that compressed tablets consist of an API and excipients—including fillers, binders, glidants, lubricants, disintegrants, coatings, and taste modifiers—that each contribute to tablet functionality, release profile, appearance, and manufacturability. The text underscores the importance of selecting appropriate granulation methods—such as wet granulation, roller compaction (dry granulation), and emerging continuous granulation systems—to optimize powder flowability, content uniformity, and compression properties. Advanced manufacturing technologies—such as tablet compression, various coating techniques, multiparticulate systems, and pellet/extrusion-spheronisation—are also discussed for their roles in addressing complex formulation needs (e.g., controlled release, rapid disintegration). Finally, the article advocates for the use of Process Analytical Technology (PAT) and Quality by Design (QbD) principles to monitor key quality attributes in real time and ensure consistent tablet quality across scale-up and production runs