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    Webinar KIN STYL'One Compaction Simulator - Starting slide-Player

    Webinar series India - STYL'One Compaction Simulator: A tool for accelerated tablet development and efficient production support

    Webinar Replays - 29/04/2024 - by Quentin Boulay, Bruno Leclercq, Pavan Porethi
    Formulation scientists are facing increasing pressure to reduce development time and cost, and quickly bring oral solid dosage forms on the market.A key to this success is using tableting technology …
    Image Right from the start Designing advanceable formulations and processes at phase 1

    Right from the start: Designing Advanceable Formulations and Processes at Phase I

    Newsfeeds - 09/04/2024 -
    The text discusses the importance of designing drug formulations and processes that are advanceable from the early stages of development, emphasizing safety, efficacy, manufacturability, and commercial viability. It highlights the …
    Illustration article Interphex

    KORSCH America highlights latest tableting technology during Interphex 2024

    Newsfeeds - 03/04/2024 -
    KORSCH America Inc., division of KORSCH AG., a leading name in the pharmaceutical equipment manufacturing industry, is preparing its participation at Interphex in New York. Scheduled from April 16th to …
    image preformulation drug development

    Best Practices For Preformulation In Drug Development

    Newsfeeds - 05/03/2024 -
    The text discusses the importance and methodologies of preformulation testing in drug development, which involves studying new drug compounds to gather essential information for formulating stable and biopharmaceutically suitable dosage …
    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Papers - 28/02/2024 - by Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
    Hydroxypropyl methylcellulose (HPMC) stands out as the favored hydrophilic matrix former in the production of controlled release formulations via continuous twin-screw wet granulation. However, previous observations have highlighted a challenge: …
    Medelpharm Science Lab tests under hood

    On the trail of solubility

    White Papers - 14/12/2023 -
    From Korbinian Löbmann | Søren Vinter Søgaard, 02.11.2022Innovative, Copenhagen-based startup Zerion Pharma utilizes the equipment and know-how of the MEDELPHARM INNOVATION CENTER (called “Science Lab” in France) for product development …
    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

    Papers - 27/11/2023 - by Dario A. Dornbierer, Laurenz Marten, Jovin Mueller, Helena D. Aicher, Michael J. Mueller, Martina Boxler, Michael Kometer, Davor Kosanic, Robin Von Rotz, Maxim Puchkov, Thomas Kraemer, Hans-Peter Landolt, Erich Seifritz, Milan Scheidegger
    Recently, the plant medicine "ayahuasca" from the Amazon, which contains the psychedelic compound N,N-dimethyltryptamine (DMT) and various β-carboline alkaloids like harmine, has been proposed as having positive effects in individuals …
    white-medication-pill-on-blue-textile-3683079.width-1200

    Characterizing drug substance properties early can optimize drug development formulation

    Newsfeeds - 23/10/2023 -
    This article examines the following key points: 1 - Early drug substance (DS) characterization is crucial as changes in the DS process can affect the drug product (DP), including purity, …
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    Predictive modelling of powder compaction for binary mixtures using the finite element method

    Papers - 12/04/2022 - by Dingeman L.H. van der Haven, Frederik H. ørtoft, Kaisa Naelapää, Ioannis S. Fragkopoulos, James A. Elliott
    In the pharmaceutical industry, the formulation of tablets remains a challenging task despite the widespread adoption of solid-form drug delivery. This challenge arises from the strong dependence of tablet properties …
    no-image

    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Papers - 25/09/2021 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    1. Introduction: The incorporation of a binder into a direct compression formulation aims to enhance tablet tensile strength and mitigate tablet defects. The internal blending of magnesium stearate (MgSt) is …
    no-image

    Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

    Papers - 10/03/2021 - by Lise Vandevivere
    The investigation focused on evaluating the appropriateness of pharmaceutical binders for continuous twin-screw wet granulation, reflecting the pharmaceutical industry's shift from batch to continuous manufacturing. A comparison was conducted between …
    no-image

    Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

    Papers - 03/02/2021 - by Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The appropriateness of pharmaceutical binders for continuous twin-screw wet granulation was examined, aligning with the pharmaceutical industry's transition from batch to continuous manufacturing. A scientific approach to binder selection is …