Close search
Resources

Newsfeeds

Favorite Articles

    Tags

    Categories

    Authors

    21 results
    Date
    A new insight into the mechanism of the tabletability flip phenomenon

    A new insight into the mechanism of the tabletability flip phenomenon

    Papers - 04/03/2024 - by Zijian Wang, Chenguang Wang, Yiwang Guo, Deepak Bahl, Alex Fok, Changquan Calvin Sun
    Tabletability arises from the dynamic interplay between interparticulate bonding area (BA) and bonding strength (BS), which is influenced by various factors such as the mechanical properties, size, shape, and surface …
    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Papers - 28/02/2024 - by Gerrit Vreeman, Danyingzi Guan, Yuncheng Cai, Qun Zhou, Changquan Calvin Sun
    Cocrystallization proves to be a potent technique for modifying the tableting performance of crystals by adjusting their mechanical attributes. This research delves into the cocrystallization of ligustrazine (LIG) with malonic …
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    Fig.-2-Tableting-study

    Tableting of liquid form active ingredient with high performance liquid carrier

    Newsfeeds - 07/11/2023 -
    The article discusses the use of FLORITE, a macro porous calcium silicate, as a practical alternative to liquid carriers for tableting formulations with liquid active ingredients.Fish oil was utilized as …
    Excipients for orally disintegrating tablets: compaction data analysis and study of tableting properties of lubricated co-processed excipients

    Excipients for orally disintegrating tablets: compaction data analysis and study of tableting properties of lubricated co-processed excipients

    Papers - 04/09/2023 - by Mayowa Onayo, Yildiz Ozalp, Nailla Jiwa, Burcu Mesut, Sevgi Gungor
    The selection of an appropriate co-processed excipient (CPE) is a critical aspect in the development of orally disintegrating tablets (ODTs). This study assessed five commonly used CPEs (Ludiflash®, Ludipress®, Ludipress® …
    The Ubiquity of the Tabletability Flip Phenomenon

    The ubiquity of the tabletability flip phenomenon

    Papers - 24/07/2023 - by Zijian Wang, Chenguang Wang, Deepak Bahl, Changquan Calvin Sun
    The malleability of materials plays a crucial role in achieving effective powder tabletability, a key factor in the development of successful tablet products. Generally, a more pliable material can generate …
    Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles

    Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles

    Papers - 25/01/2023 - by Mahdieh Dagina Pedersen, Andrew Megarry, Kaisa Naelapää, Thomas Rades, Jenni Pessi
    The oral administration of proteins and peptides is an appealing option for dosing due to its high patient compliance. However, formulating these macromolecules for oral delivery often involves incorporating permeation …
    Improving the Manufacturability of Cohesive and Poorly Compactable API for Direct Compression of Mini-tablets at High Drug Loading via Particle Engineering

    Improving the manufacturability of cohesive and poorly compactable API for direct compression of mini-tablets at high drug loading via particle engineering

    Papers - 01/11/2022 - by Liang Chen, Yiqing Lin, Erwin Irdam, Nicole Madden, Frederick Osei-Yeboah
    The aim is to employ a particle engineering approach to enhance the manufacturability of a cohesive and challenging-to-compact active pharmaceutical ingredient (API) with a high drug loading, specifically for the …
    no-image

    Understanding the multidimensional effects of polymorphism, particle size and processing for D-Mannitol powders

    Papers - 07/10/2022 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    This study investigated the influence of polymorphic form, particle size, and processing of mannitol on the mechanical properties of solid oral dosage forms. The particle and powder properties of spray …
    A powder tabletability equation

    A powder tabletability equation

    Papers - 12/07/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    A formula depicting the tensile strength of tablets in relation to compaction pressure was developed based on the equations proposed by Ryshkewitch and Kuentz-Leuenberger. This equation was employed to model …
    no-image

    A fundamental step in your tablet development

    Bulletins - 01/09/2021 - by Adrien Pelloux
    Formulation development and technical transfer from lab to production can be challenging and requires a deep knowledge of your formulation. The integrated and intuitive data analysis features drive formulators and …
    Evaluation of tableting performance of poly (ethylene oxide) in abuse-deterrent formulations using compaction simulation studies

    Evaluation of tableting performance of poly (ethylene oxide) in abuse-deterrent formulations using compaction simulation studies

    Papers - 15/03/2021 - by Dongyue Yu, Raghunadha Reddy Seelam, Feng Zhang, Stephen R. Byrn, Stephen W. Hoag
    Poly (ethylene oxide) (PEO) is extensively employed in abuse-deterrent formulations (ADFs) to enhance tablet hardness. Previous research has demonstrated that various formulation factors, such as processing conditions and the particle …