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    Dry granulation in solid oral formulation- advantages of spray-dried mannitol - image

    Dry granulation in solid oral formulation: advantages of spray-dried mannitol in roll compaction

    Newsfeeds - 25/09/2025 -
    The article explores the benefits of spray-dried mannitol as a filler/binder in dry granulation via roller compaction, a technique particularly suited to moisture- and heat-sensitive APIs since it avoids wet …
    Predicting the tabletability of binary powder mixtures from that of individual components

    Predicting the tabletability of binary powder mixtures from that of individual components

    Papers - 29/05/2025 - by Vedant Girish Bhagali, Gerrit Vreeman, Aakash Hasabnis, Changquan Calvin Sun
    Predicting the tabletability—defined as the relationship between tensile strength and compaction pressure—of powder mixtures based on the tabletability of pure components can significantly streamline the tablet formulation process, saving both …
    Influences_variation_compressed material_image

    Influences of variations of the amount of compressed material on compressibility, tabletability and compactability

    Papers - 10/05/2025 - by Anh Tuan Tran, Stefan Klinken-Uth
    Compression analysis plays a critical role in evaluating materials and optimizing processes in pharmaceutical tablet manufacturing. While previous studies have examined how various process parameters — such as compression speed …
    High-dose modified release formulation-image

    High-dose modified-release formulation of a poorly soluble drug via twin-screw melt coating and granulation

    Newsfeeds - 17/02/2025 -
    Favipiravir, an antiviral drug for COVID-19 with poor water solubility, is formulated using a low-cost melt coating and granulation method. High-dose tablets (600 mg and 800 mg) with desired release …
    Elucidating critical factors driving the tabletability flip phenomenon

    Elucidating critical factors driving the tabletability flip phenomenon

    Papers - 10/02/2025 - by Zijian Wang, Chenguang Wang, Changquan Calvin Sun
    Tabletability is a crucial property that determines a powder's ability to form tablets under applied stresses, typically illustrated by a plot of tablet tensile strength versus pressure. Tablet tensile strength …
    A new insight into the mechanism of the tabletability flip phenomenon

    A new insight into the mechanism of the tabletability flip phenomenon

    Papers - 04/03/2024 - by Zijian Wang, Chenguang Wang, Yiwang Guo, Deepak Bahl, Alex Fok, Changquan Calvin Sun
    Tabletability arises from the dynamic interplay between interparticulate bonding area (BA) and bonding strength (BS), which is influenced by various factors such as the mechanical properties, size, shape, and surface …
    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Cocrystallization improves the tabletability of ligustrazine despite a reduction in plasticity

    Papers - 28/02/2024 - by Gerrit Vreeman, Danyingzi Guan, Yuncheng Cai, Qun Zhou, Changquan Calvin Sun
    Cocrystallization proves to be a potent technique for modifying the tableting performance of crystals by adjusting their mechanical attributes. This research delves into the cocrystallization of ligustrazine (LIG) with malonic …
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    Fig.-2-Tableting-study

    Tableting of liquid form active ingredient with high performance liquid carrier

    Newsfeeds - 07/11/2023 -
    The article discusses the use of FLORITE, a macro porous calcium silicate, as a practical alternative to liquid carriers for tableting formulations with liquid active ingredients.Fish oil was utilized as …
    orally disintegrating tablets

    Excipients for orally disintegrating tablets: compaction data analysis and study of tableting properties of lubricated co-processed excipients

    Papers - 04/09/2023 - by Mayowa Onayo, Yildiz Ozalp, Nailla Jiwa, Burcu Mesut, Sevgi Gungor
    The selection of an appropriate co-processed excipient (CPE) is a critical aspect in the development of orally disintegrating tablets (ODTs). This study assessed five commonly used CPEs (Ludiflash®, Ludipress®, Ludipress® …
    The Ubiquity of the Tabletability Flip Phenomenon

    The ubiquity of the tabletability flip phenomenon

    Papers - 24/07/2023 - by Zijian Wang, Chenguang Wang, Deepak Bahl, Changquan Calvin Sun
    The malleability of materials plays a crucial role in achieving effective powder tabletability, a key factor in the development of successful tablet products. Generally, a more pliable material can generate …
    Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles

    Enhancing tabletability of high-dose tablets by tailoring properties of spray-dried insulin particles

    Papers - 25/01/2023 - by Mahdieh Dagina Pedersen, Andrew Megarry, Kaisa Naelapää, Thomas Rades, Jenni Pessi
    The oral administration of proteins and peptides is an appealing option for dosing due to its high patient compliance. However, formulating these macromolecules for oral delivery often involves incorporating permeation …