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    Effect of Liquid Load Level and Binder Type on the Tabletability of Mesoporous Silica Based Liquisolids

    Effect of liquid load level and binder type on the tabletability of mesoporous silica based liquisolids

    Papers - 21/10/2024 - by Jan Appelhaus, Kristina E. Steffens, Karl G. Wagner
    Mesoporous silica facilitates the conversion of liquids into solids due to its high capacity to load liquid or dissolved active ingredients, enhancing dissolution properties. However, compressing both unloaded and loaded …
    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Papers - 25/06/2024 - by Claudia Köster, Peter Kleinebudde
    This study examined the impact of hydroxypropyl cellulose (HPC) type (HPC-SSL SFP, HPC-SSL), binder concentration (2%, 3.5%, 5%), and filler type (lactose, or calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on …
    Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

    Effect of hydroxy propyl cellulose grade and foam quality on foam granulation of a high drug load formulation

    Papers - 25/05/2024 - by Otilia Koo, Chandrakant Patel, Faranak Nikfar
    Foam granulation presents a relatively novel approach to wet granulation, where foamed binder solutions are introduced to powder mixtures in the mixer. This serves to mitigate issues of localized over-wetting …
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    Use of Polyvinyl Alcohol as an effective binder in continuous Twin-Screw Granulation

    Papers - 01/02/2024 - by Gudrun Birk, Anja-Nadine Knüttel, Almut von der Brelie
    Granulation of powder blends is a frequently employed method in pharmaceutical formulations when there are issues with flowability, compactability, or uniformity in terms of the active pharmaceutical ingredient (API) content. …
    Tableting Performance of Maize and Potato Starches Used in Combination as Binder/Disintegrant in Metronidazole Tablet Formulation

    Tableting performance of maize and potato starches used in combination as binder/disintegrant in Metronidazole tablet formulation

    Papers - 01/10/2022 - by Yonni Eshovo Apeji, Rejoice Thomas Kaigama, Sani Hadi Ibrahim, Sophie Nock Anyebe, Aisha Ohunene Abdussalam, Avosuahi Rukayat Oyi
    The objective of this study was to evaluate the tableting characteristics of maize and potato starches when employed either as disintegrants or binders in the development of solid dosage forms. …
    Comparison of hydroxypropylcellulose and hot-melt extrudable hypromellose in twin-screw melt granulation of metformin hydrochloride: effect of rheological properties of polymer on melt granulation and granule properties

    Comparison of hydroxypropylcellulose and hot-melt extrudable hypromellose in twin-screw melt granulation of metformin hydrochloride: effect of rheological properties of polymer on melt granulation and granule properties

    Papers - 23/12/2021 - by Amol Batra, Fengyuan Yang, Michael Kogan, Anthony Sosnowik, Courtney Usher, Eugene W. Oldham, Ningyi Chen, Kamaru Lawal, Yunxia Bi, Thomas Dürig
    High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely recognized as extended-release polymers. While conventional high-molecular-weight HPMCs are preferred for extended-release applications, their use in twin-screw melt granulation is limited …
    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Effect of binder type and lubrication method on the binder efficacy for direct compression

    Papers - 25/09/2021 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    1. Introduction: The incorporation of a binder into a direct compression formulation aims to enhance tablet tensile strength and mitigate tablet defects. The internal blending of magnesium stearate (MgSt) is …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 10/03/2021 - by Lise Vandevivere
    The investigation focused on evaluating the appropriateness of pharmaceutical binders for continuous twin-screw wet granulation, reflecting the pharmaceutical industry's shift from batch to continuous manufacturing. A comparison was conducted between …
    Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

    Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

    Papers - 14/10/2020 - by Kristina E. Steffens, Marvin B. Brenner, Michael U. Hartig, Marius Monschke, Karl G. Wagner
    Melt granules containing DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were produced using a twin-screw granulator (TSG) under five different conditions (varied screw speed and throughput). These were then compared …
    Advantages of Mannitol in Pharmaceutical Granulation Processes - bulletin

    Advantages of mannitol in pharmaceutical granulation processes - a comparison of different polymorphic forms

    Bulletins - 01/09/2020 - by Hans-Leonhard Ohrem
    The success of a wet granulation process depends on use of an excipient with excellent binding and compaction properties. Mannitol is frequently used for this purpose in solid dosage formulations …
    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Papers - 30/07/2020 - by L. Vandevivere, P. Denduyver, C. Portier, O. Häusler, T. De Beer, C. Vervaet, V. Vanhoorne
    The impact of various binders on the quality of granules produced through continuous twin-screw wet granulation was investigated. Anhydrous dicalcium phosphate served as a poorly soluble filler, and binders were …
    Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution

    Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution

    Papers - 01/10/2019 - by Kristina E. Steffens, Karl G. Wagner
    This study investigated how the tabletability and compactibility of granules, formed through twin-screw melt granulation, are influenced by the distribution of binders. Two grades of dicalcium phosphate anhydrous (fine and …