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    Predicting the tabletability of binary powder mixtures from that of individual components

    Predicting the tabletability of binary powder mixtures from that of individual components

    Papers - 29/05/2025 - by Vedant Girish Bhagali, Gerrit Vreeman, Aakash Hasabnis, Changquan Calvin Sun
    Predicting the tabletability—defined as the relationship between tensile strength and compaction pressure—of powder mixtures based on the tabletability of pure components can significantly streamline the tablet formulation process, saving both …
    Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

    Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

    Papers - 04/01/2025 - by Chenyu Wu, Zijian Wang, Xu Han, Xinyi Yu, Changquan Calvin Sun, Zhengzheng Zhou
    Diclofenac (DIC), a nonsteroidal anti-inflammatory drug, is characterized by poor tabletability and low water solubility. This study introduces a novel diclofenac-picolinamide cocrystal (DIC-PIC) aimed at improving both properties. The cocrystal …
    The effect of granules characters on mechanical properties of press-coated tablets: A comparative study

    The effect of granules characters on mechanical properties of press-coated tablets: A comparative study

    Papers - 25/08/2022 - by Peifu Xiao, Yibin Guo, Jiahui Wang, Hongbing Liu, JiaXin Zhang, YanJiao Wang, Tian Yin, Yu Zhang, Jingxin Gou, Haibing He, Xing Tang
    The objective of this study was to examine the relationship between crucial granule characteristics (including particle size, surface roughness, and apparent porosity) and the mechanical properties of press-coated tablets. Granules …
    Predictive modelling of powder compaction for binary mixtures using the finite element method

    Predictive modelling of powder compaction for binary mixtures using the finite element method

    Papers - 12/04/2022 - by Dingeman L.H. van der Haven, Frederik H. ørtoft, Kaisa Naelapää, Ioannis S. Fragkopoulos, James A. Elliott
    In the pharmaceutical industry, the formulation of tablets remains a challenging task despite the widespread adoption of solid-form drug delivery. This challenge arises from the strong dependence of tablet properties …
    Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters

    Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters

    Papers - 25/01/2022 - by Léo Picart, Vincent Mazel, Aline Moulin, Vanessa Bourgeaux, Pierre Tchoreloff
    Press-coated tablets are a highly regarded technology in chronopharmaceutics, particularly for modified release applications. At the industrial level, assessing mechanical resistance is of paramount importance during both the development and …
    Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

    Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

    Papers - 10/08/2021 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping and lamination are common defects encountered in the pharmaceutical tablet manufacturing process. Numerous studies have indicated that tablet anisotropy can contribute to the occurrence of such defects. This study …
    Effects of compaction and storage conditions on stability of intravenous immunoglobulin - implication on developing oral tablets of biologics

    Effects of compaction and storage conditions on stability of intravenous immunoglobulin - implication on developing oral tablets of biologics

    Papers - 26/05/2021 - by Yuwei Lu, Chenguang Wang, Bowen Jiang, Changquan Calvin Sun, Stephen W. Hoag
    Biological products, encompassing therapeutic proteins, vaccines, and cell-based therapeutics, are witnessing rapid growth in the global market. Monoclonal antibodies, in particular, constitute a substantial portion of the biologics market. When …
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    Effect of the curvature of the punches on the shape of the interface and the delamination tendency of bilayer tablets

    Papers - 01/05/2017 - by Luca Castrati, Vincent Mazel, Harona Diarra, Virginie Busignies, Pierre Tchoreloff
    Bilayer tablets hold special significance in the pharmaceutical industry, and a primary challenge in their manufacturing is the occurrence of delamination during or after ejection from the die. This study …
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    Press-coated tablets increased knowledge through research

    Bulletins - 01/01/2017 -
    Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

    Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

    Papers - 17/02/2015 - by Dilbir S. Bindra, Sridhar Desikan
    The processability of a high drug loading formulation can be notably influenced by the physical characteristics of an active pharmaceutical ingredient (API). This paper illustrates a case where distinct micromeritic …
    Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

    Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets

    Papers - 30/11/2013 - by Virginie Busignies, Vincent Mazel, Harona Diarra, Pierre Tchoreloff
    The impact of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was explored. The elastic properties of five pharmaceutical products were assessed based on their …
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    On the links between elastic constants and effective elastic behavior of pharmaceutical compacts: importance of poisson's ratio and use of bulk modulus

    Papers - 01/11/2013 - by Vincent Mazel, Virginie Busignies, Harona Diarra, Pierre Tchoreloff
    The elastic properties of pharmaceutical powders and compacts play a crucial role in comprehending the intricate phenomena occurring during and after the tableting process. Elastic recovery following compression is known …
    Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

    Measurements of elastic moduli of pharmaceutical compacts: A new methodology using double compaction on a compaction simulator

    Papers - 01/06/2012 - by Vincent Mazel, Virginie Busignies, Harona Diarra, Pierre Tchoreloff
    The compaction process heavily relies on the elastic properties of pharmaceutical powders. Young's modulus (E) and Poisson's ratio (v) are key parameters representing the elastic behavior. However, as the powder …