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Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

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The processability of a high drug loading formulation can be notably influenced by the physical characteristics of an active pharmaceutical ingredient (API). This paper illustrates a case where distinct micromeritic properties of an API were achieved through crystallization under varied conditions, leading to divergent tableting behavior. Despite maintaining the API form purity during the altered crystallization process, substantial modifications occurred in the surface geometry, porosity, and surface area of the API. Batches composed of particles exhibiting greater surface irregularity and porosity yielded tablets with superior mechanical strength.
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