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    Defects in tablet production KORSCH

    Understanding the powder compression phase - and avoiding tablet defects

    White Papers - 14/10/2024 -
    From Vincent Mazel, 19.06.2024The tableting process looks simple, but is complex and irreversible: the University of Bordeaux is learning together with the tableting specialists.Expert in physics and mechanics, highly regarded …
    MEDELPHARM_CPHI_Nano_Demonstration

    MEDELPHARM and Armor Pharma collaborate for innovative formulation development at CPHI 2024

    Newsfeeds - 03/10/2024 -
    MEDELPHARM is excited to announce its participation at CPHI 2024 in Milan, exhibiting in collaboration with Armor Pharma, a leading manufacturer of pharmaceutical excipients. Together, they will present live demonstrations …
    Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time

    Dwell time on tableting: dwell time according to force versus geometric dwell time

    Papers - 24/07/2024 - by Valentyn Mohylyuk
    Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can …
    STYL'One Nano-DMU tabletting school-Sixtine

    Leveraging the STYL'One Nano compaction simulator for educational purposes

    Newsfeeds - 11/07/2024 -
    In the rapidly evolving field of pharmaceutical sciences, innovative tools and technologies are essential to advancing research and development. One such innovative instrument is the STYL'One Nano, offered by MEDELPHARM. …
    Image MEDELPHARM STYL'One Nano for early-stage characterization

    STYL’One Nano R&D compaction simulator for early-stage material characterization and development

    Newsfeeds - 13/06/2024 -
    The MEDELPHARM STYL’One Nano is a compact and advanced compaction simulator designed for early-stage tablet formulation in research and development. It helps researchers address formulation challenges in tablet and oral …
    _DSC2084 copie

    MEDELPHARM bringing expertise in research and development at Compaction Simulation Forum in Dublin

    Newsfeeds - 22/04/2024 -
    MEDELPHARM, a leading name in pharmaceutical equipment and technology, is getting ready to participate at the upcoming Compaction Simulation Forum (CSF), scheduled to take place from June 4th to 6th …
    Tablet_Multilayer_15_HD.original

    The effect of compression pressure on the first layer surface roughness and delamination of Metformin and Evogliptin bilayer and trilayer tablets

    Newsfeeds - 18/12/2023 -
    The study aimed to assess the delamination of convex-shaped tablets containing metformin HCl (MF) and evogliptin tartrate (EG) based on pre-compression and main compression pressures. Simultaneously, the study sought to …
    Image Korsch BASF understanding of materials

    Everything starts with an understanding of the materials

    White Papers - 18/12/2023 -
    Simulators and software solutions provide valuable product development support when appropriate raw materials need to be selected.Sound knowledge of the active pharmaceutical ingredient (API) to be formulated and the required …
    Compaction simulator & scientist

    Why use a compaction simulator?

    White Papers - 30/11/2023 - by Bruno Leclercq
    Development of pharmaceutical dosage forms requires the careful characterization and under-standing of the formulation, including active pharmaceutical ingredients (APIs) and excipients, and of the compression process.One of the most significant …
    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Papers - 06/05/2023 - by Chamara A. Gunawardana, Angela Kong, Debbie Wanapun, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, John E. Kresevic, Changquan Calvin Sun
    The adherence of active pharmaceutical ingredient (API) to compaction tooling surfaces, commonly known as punch sticking, can lead to costly downtime or product failures during commercial tablet manufacturing. Magnesium stearate …
    The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

    The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

    Papers - 07/04/2023 - by Keirnan LaMarche, David Trinkle, Brian Zacour, Sherif Badawy
    An increasingly utilized model for the compaction process in the pharmaceutical industry is the Drucker-Prager Cap model (DPC). Historically, it has been employed in conjunction with finite element methods to …
    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Papers - 04/04/2023 - by Daniel Puckhaber, Anna-Lena Voges, Supriya Rane, Sarah David, Bindhumadhavan Gururajan, Jan Henrik Finke, Arno Kwade
    Modeling the structural and mechanical properties of tablets composed of multiple components, based on a minimal amount of experimental data, is of great interest to minimize the time and cost …
    Multivariate data analysis to evaluate commonly used compression descriptors

    Multivariate data analysis to evaluate commonly used compression descriptors

    Papers - 27/03/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Numerous studies have delved into material behavior through compression analyses, with a particular emphasis on compressibility, compactibility, and tabletability. In this study, an extensive multivariate data analysis was conducted using …
    The Effect of Particle Shape on the Compaction of Realistic Non-Spherical Particles—A Multi-Contact DEM Study

    The effect of particle shape on the compaction of realistic non-spherical particles—a multi-contact DEM study

    Papers - 10/03/2023 - by Kostas Giannis, Arno Kwade, Jan Henrik Finke, Carsten Schilde
    This study aimed to explore the deformation behavior of non-spherical particles under high-load compaction using the multi-contact discrete element method (MC-DEM). Two methods were employed to account for non-spherical particles: …
    no-image

    Understanding the implication of Kawakita model parameters using in-die force-displacement curve analysis for compacted and non-compacted API powders

    Papers - 01/12/2022 - by Iyad Rashid, Rula Raji Haddadin, Ashaar Abdulsalam Alkafaween, Rawan Nayef Alkaraki, Rehan Mohammad Alkasasbeh
    The objective of this investigation was to explore powder mechanics during compression by analyzing data derived from force-displacement (F-D) curves. The study employed the Kawakita model of powder compression analysis …
    Development of a multiparticulate drug delivery system for in situ amorphisation

    Development of a multiparticulate drug delivery system for in situ amorphisation

    Papers - 01/10/2022 - by Tobias Palle Holm, Marcel Kokott, Matthias Manne Knopp, Ben J. Boyd, Ragna Berthelsen, Julian Quodbach, Korbinian Löbmann
    In this study, the application of multiparticulate drug delivery systems (MDDS) was explored for tablets designed to amorphize supersaturated granular amorphous solid dispersions (ASDs) in situ—specifically, achieving amorphization through microwave …
    Compressibility analysis as robust in-die compression analysis for describing tableting behaviour

    Compressibility analysis as robust in-die compression analysis for describing tableting behaviour

    Papers - 01/09/2022 - by Sabrina Berkenkemper, Peter Kleinebudde
    Objectives: The compressibility of materials plays a crucial role in determining the tableting behavior and tablet properties throughout and after the manufacturing process. In this study, we explored the compressibility …
    Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression

    Hydrochlorothiazide/losartan potassium tablet prepared by direct compression

    Papers - 21/08/2022 - by Luo Qiuhua, Zhang Qianying, Wang Puxiu
    Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) served as a model drug for the preparation of compound tablets. The investigation focused on the compression and mechanical properties of mixed powders to identify formulation …
    Influence of the punch shape on the core and shell structure of press-coated tablets

    Influence of the punch shape on the core and shell structure of press-coated tablets

    Papers - 25/07/2022 - by Léo Picart, Vincent Mazel, Aline Moulin, Vanessa Bourgeaux, Pierre Tchoreloff
    Press-coated tablets play a pivotal role in achieving delayed releases in chronotherapeutics, with their drug release properties intricately tied to their distinctive core-shell structure. Therefore, understanding the impact of process …
    On the complexity of predicting tablet capping

    On the complexity of predicting tablet capping

    Papers - 23/06/2022 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Anticipating tablet defects, particularly capping, during the pharmaceutical manufacturing process poses a considerable challenge. The existing literature presents various parameters for predicting capping, yet a consensus has not been reached. …