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Scientific papers

Explore a selection of scientific papers featuring research conducted with STYL’One Compaction Simulators. Discover how leading scientists and institutions use STYL’One technology to advance understanding in powder compression, tablet formulation development, and process innovation.

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    Compaction simulators - STYL'One Nano-s

    STYL'One University Contest: Winners announced!

    Newsfeed - 07/10/2025 -
    The STYL’One University Contest, launched last February by MEDELPHARM and KORSCH, has officially reached its conclusion. This first edition invited universities from around the world to submit innovative projects in …
    Capture Virtual Pharma Expo

    Predictive tablet press scale-up from R&D to production with STYL’One Evo Compaction Simulator

    Newsfeed - 26/09/2025 -
    At the Virtual Pharma Expo 2025, KORSCH America showcased the STYL’One Evo Compaction Simulator, a cutting-edge solution that helps pharmaceutical formulators predict high-speed tablet performance and accelerate scale-up from lab …
    image STYO University Contest

    STYL'One University Contest: Meet the four finalists

    Newsfeed - 15/07/2025 -
    The first phase of the STYL’One University Contest has officially concluded, and we’re thrilled to announce the four universities selected to advance to the next round. This international competition, launched …
    Refining rotary press parameters for consistent tablet quality during product transfer

    Refining rotary press parameters for consistent tablet quality during product transfer

    Papers - 17/03/2025 - by Friederike Gütter, Moritz Rosch
    The goal of this study was to develop a fast and material-sparing method to optimize compaction and die filling processes for tablet manufacturing at high-speed production.
    Refining rotary press parameters for consistent tablet quality during product transfer

    Refining rotary press parameters for consistent tablet quality during product transfer

    Posters - 17/03/2025 - by Friederike Gütter, Moritz Rosch
    The goal of this study was to develop a fast and material-sparing method to optimize compaction and die filling processes for tablet manufacturing at high-speed production.
    Impact of solid content on the bulk properties of lyophilized powders

    Impact of solid content on the bulk properties of lyophilized powders

    Papers - 10/02/2025 - by Zijian Wang, Sichen Song, Hongwei Zhang, Xiaohong Liu, Ronald A. Siegel, Changquan Calvin Sun, Chenguang Wang
    Interest in the oral delivery of biologics, often formulated via lyophilization, is growing rapidly. Lyophilization typically uses solutions with low solid content to optimize mass transfer and reduce drying time. …
    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Influence of multiple compression phases during tableting of spray dried Saccharomyces cerevisiae on microbial survival and physical–mechanical tablet properties

    Papers - 18/11/2024 - by Karl Vorländer, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    The viability of probiotic microorganisms is critical for their health benefits and must be carefully preserved throughout the production of final dosage forms, such as tablets. This includes processes like …
    Defects in tablet production KORSCH

    Understanding the powder compression phase - and avoiding tablet defects

    Whitepapers - 14/10/2024 -
    From Vincent Mazel, 19.06.2024The tableting process looks simple, but is complex and irreversible: the University of Bordeaux is learning together with the tableting specialists.Expert in physics and mechanics, highly regarded …
    MEDELPHARM_CPHI_Nano_Demonstration

    MEDELPHARM and Armor Pharma collaborate for innovative formulation development at CPHI 2024

    Newsfeed - 03/10/2024 -
    MEDELPHARM is excited to announce its participation at CPHI 2024 in Milan, exhibiting in collaboration with Armor Pharma, a leading manufacturer of pharmaceutical excipients. Together, they will present live demonstrations …
    Dwell Time on Tableting: Dwell Time According to Force versus Geometric Dwell Time

    Dwell time on tableting: dwell time according to force versus geometric dwell time

    Papers - 24/07/2024 - by Valentyn Mohylyuk
    Dwell time is a key parameter influencing the material deformation and the mechanical and biopharmaceutical properties of a tablet, making it essential for scale-up processes. Geometric dwell time (GDT) can …
    STYL'One Nano-DMU tabletting school-Sixtine

    Leveraging the STYL'One Nano compaction simulator for educational purposes

    Newsfeed - 11/07/2024 -
    In the rapidly evolving field of pharmaceutical sciences, innovative tools and technologies are essential to advancing research and development. One such innovative instrument is the STYL'One Nano, offered by MEDELPHARM. …
    Image MEDELPHARM STYL'One Nano for early-stage characterization

    STYL’One Nano R&D compaction simulator for early-stage material characterization and development

    Newsfeed - 13/06/2024 -
    The MEDELPHARM STYL’One Nano is a compact and advanced compaction simulator designed for early-stage tablet formulation in research and development. It helps researchers address formulation challenges in tablet and oral …
    _DSC2084 copie

    MEDELPHARM bringing expertise in research and development at Compaction Simulation Forum in Dublin

    Newsfeed - 22/04/2024 -
    MEDELPHARM, a leading name in pharmaceutical equipment and technology, is getting ready to participate at the upcoming Compaction Simulation Forum (CSF), scheduled to take place from June 4th to 6th …
    Tablet_Multilayer_15_HD.original

    The effect of compression pressure on the first layer surface roughness and delamination of Metformin and Evogliptin bilayer and trilayer tablets

    Newsfeed - 18/12/2023 -
    The study aimed to assess the delamination of convex-shaped tablets containing metformin HCl (MF) and evogliptin tartrate (EG) based on pre-compression and main compression pressures. Simultaneously, the study sought to …
    Image Korsch BASF understanding of materials

    Everything starts with an understanding of the materials

    Whitepapers - 18/12/2023 -
    Simulators and software solutions provide valuable product development support when appropriate raw materials need to be selected.Sound knowledge of the active pharmaceutical ingredient (API) to be formulated and the required …
    Compaction simulator & scientist

    Why use a compaction simulator?

    Whitepapers - 30/11/2023 - by Bruno Leclercq
    Development of pharmaceutical dosage forms requires the careful characterization and under-standing of the formulation, including active pharmaceutical ingredients (APIs) and excipients, and of the compression process.One of the most significant …
    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Papers - 06/05/2023 - by Chamara A. Gunawardana, Angela Kong, Debbie Wanapun, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, John E. Kresevic, Changquan Calvin Sun
    The adherence of active pharmaceutical ingredient (API) to compaction tooling surfaces, commonly known as punch sticking, can lead to costly downtime or product failures during commercial tablet manufacturing. Magnesium stearate …
    The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

    The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

    Papers - 07/04/2023 - by Keirnan LaMarche, David Trinkle, Brian Zacour, Sherif Badawy
    An increasingly utilized model for the compaction process in the pharmaceutical industry is the Drucker-Prager Cap model (DPC). Historically, it has been employed in conjunction with finite element methods to …
    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Papers - 04/04/2023 - by Daniel Puckhaber, Anna-Lena Voges, Supriya Rane, Sarah David, Bindhumadhavan Gururajan, Jan Henrik Finke, Arno Kwade
    Modeling the structural and mechanical properties of tablets composed of multiple components, based on a minimal amount of experimental data, is of great interest to minimize the time and cost …
    Multivariate data analysis to evaluate commonly used compression descriptors

    Multivariate data analysis to evaluate commonly used compression descriptors

    Papers - 27/03/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Numerous studies have delved into material behavior through compression analyses, with a particular emphasis on compressibility, compactibility, and tabletability. In this study, an extensive multivariate data analysis was conducted using …