The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials
April 7, 2023, midnight
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An increasingly utilized model for the compaction process in the pharmaceutical industry is the Drucker-Prager Cap model (DPC). Historically, it has been employed in conjunction with finite element methods to simulate density and stress distributions in compacts. More recently, the calibrated parameters constituting the model have been applied to characterize the material properties of various compounds. This study compiles DPC parameters from 60 materials, presenting a summary of the findings. From this dataset, several crucial conclusions can be drawn regarding both typical and extreme behaviors of formulations and excipients. These insights provide key indicators of program risk that can be identified and utilized early in the formulation development process, helping to avoid costly manufacturing and scale-up issues.