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Scientific papers

Explore a selection of scientific papers featuring research conducted with STYL’One Compaction Simulators. Discover how leading scientists and institutions use STYL’One technology to advance understanding in powder compression, tablet formulation development, and process innovation.

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    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Posters - 20/10/2024 - by James Stephens, Nitin Kumar Swarnakar, Ming Ji, Sandip Tiwari
    The aim of this study was to optimize the formulation and production process of pharmaceutical tablets using an integrated approach involving algorithm-based formulation tool (ZoomLab®) and a compaction simulator (STYL’One …
    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Optimizing tablet formulation through integrated use of digital formulation tools and compaction simulation

    Papers - 20/10/2024 - by James Stephens, Nitin Kumar Swarnakar, Ming Ji, Sandip Tiwari
    The aim of this study was to optimize the formulation and production process of pharmaceutical tablets using an integrated approach involving algorithm-based formulation tool (ZoomLab®) and a compaction simulator (STYL’One …
    Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations

    Effect of tableting temperature on tablet properties and dissolution behavior of heat sensitive formulations

    Papers - 15/12/2023 - by Hanna Dorothea Grumann, Peter Kleinebudde
    The process of tableting involves transforming mechanical energy into thermal energy. This study assessed how temperature affects the tableting characteristics of formulations with varying compositions. A tableting machine equipped with …
    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

    Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    Simulation of roller compaction by combination of a compaction simulator and oscillating mill – A material sparing approach

    Simulation of roller compaction by combination of a compaction simulator and oscillating mill – A material sparing approach

    Papers - 29/07/2023 - by Layla Hassan, René Jensen, Andrew Megarry, Lasse I Blaabjerg
    This study explores the feasibility of employing a compaction simulator and an oscillating mill as a material-saving approach to simulate a roller compactor for process development. Microcrystalline cellulose and dicalcium …
    Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models

    Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models

    Papers - 25/07/2023 - by Vincent Mazel, Jérémie Girardot, Jean-Benoit Kopp, Stéphane Morel, Pierre Tchoreloff
    The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature …
    Comparison of scale-up strategies in twin-screw wet granulation

    Comparison of scale-up strategies in twin-screw wet granulation

    Papers - 25/06/2023 - by Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt, Peter Kleinebudde
    This study aimed to evaluate different scale-up strategies in twin-screw wet granulation and assess their impact on granule and tablet properties for a specific formulation. The granulation process was transitioned …
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    Structural and functional analysis of a new co-processed tableting excipient for food compaction processes

    Papers - 20/06/2023 - by René Rösemeier-Scheumann, Lars Wagner, Ulrich Bobe, Annabel Bozon, Arno Kwade, Jan Henrik Finke
    Food compacts offer convenience to both the industry and customers, necessitating a robust strength to endure the rigors of packaging processes and customer handling. Unlike pharmaceutical applications, where excipient choices …
    Investigating compressibility descriptors for binary mixtures of different deformation behavior

    Investigating compressibility descriptors for binary mixtures of different deformation behavior

    Papers - 15/06/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Tablets remain one of the most crucial dosage forms, and a key objective in the development of these forms is predicting their tableting behavior. The endeavor to save resources and …
    Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray drying and tableting

    Process and formulation parameters influencing the survival of Saccharomyces cerevisiae during spray drying and tableting

    Papers - 05/06/2023 - by Karl Vorländer, Paula Pramann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    Probiotic microorganisms offer health benefits when administered in a viable form and at adequate doses. Dry dosage forms, particularly tablets, are preferred due to their numerous advantages. However, it is …
    Tableting of fluidized bed granules containing living microorganisms

    Tableting of fluidized bed granules containing living microorganisms

    Papers - 01/06/2023 - by Karl Vorländer, Lukas Bahlmann, Arno Kwade, Jan Henrik Finke, Ingo Kampen
    Tablets stand out as the preferred dosage form for numerous active pharmaceutical ingredients due to their ease of administration, secure dosing, and cost-effective large-scale production. This form is frequently selected …
    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    A study on the pelletization and solidification of Cs-contaminated soil after soil washing

    Papers - 01/06/2023 - by Jun-Yeol An, Ki-Tae Yang, Min-Ho Lee, Sang-Hyun Lim, Sun-Il Kim, Jong-Soon Song
    The release of radioactive substances during a nuclear power plant accident can result in soil contamination over a wide area. Soil washing, employed as a decontamination technique for cesium (Cs)-contaminated …
    Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO extrudates

    Exploiting common ion addition to accelerate zolpidem hemitartrate release from Eudragit EPO extrudates

    Papers - 30/05/2023 - by S. Henry, L. Descamps, V. Vanhoorne, J.P. Remon, C. Vervaet
    The present study aimed to optimize a previously developed non-clinical formulation for zolpidem deprescribing. The formulation under investigation comprises extruded mixtures of zolpidem hemitartrate (30% w/w) and Eudragit EPO (70% …
    The application of Near-Infrared Spatially Resolved Spectroscopy in scope of achieving continuous real-time quality monitoring and control of tablets with challenging dimensions

    The application of near-infrared spatially resolved spectroscopy in scope of achieving continuous real-time quality monitoring and control of tablets with challenging dimensions

    Papers - 19/05/2023 - by A. De Man, J.-S. Uyttersprot, P.-F. Chavez, F. Vandenbroucke, F. Bovart, T. De Beer
    To achieve real-time release of tablets, it is imperative to monitor and control quality attributes using Process Analytical Technology tools like near-infrared spectroscopy (NIRS). The authors investigated the applicability of …
    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

    Papers - 06/05/2023 - by Chamara A. Gunawardana, Angela Kong, Debbie Wanapun, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, John E. Kresevic, Changquan Calvin Sun
    The adherence of active pharmaceutical ingredient (API) to compaction tooling surfaces, commonly known as punch sticking, can lead to costly downtime or product failures during commercial tablet manufacturing. Magnesium stearate …
    Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

    Solidification of radioactive soil waste through volume reduction and stabilization: Characteristic evaluation and waste acceptance criteria satisfaction

    Papers - 01/05/2023 - by Sang-Hyun Lim, Sang-Heon Lee, Jong-Soon Song, Ki-Hong Kim
    The disposal of radioactive soil waste poses a global environmental challenge, necessitating effective management strategies. To address this issue, pelletization technology can be employed to reduce the physical volume of …
    Reduced-order hybrid modelling for powder compaction: predicting density and classifying diametrical hardness

    Reduced-order hybrid modelling for powder compaction: predicting density and classifying diametrical hardness

    Papers - 19/04/2023 - by Maia Trower, Joe Emerson, Mingzhe Yu, Vincenzino Vivacqua, Johnson Timothy, Hugh Stitt, Gonçalo dos Reis
    Utilizing both machine learning (ML) techniques and physics-based modeling, this study introduces two feature-based reduced-order models. One model is designed for the quantitative prediction of density, while the other is …
    The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

    The distribution of Drucker-Prager Cap model parameters for pharmaceutical materials

    Papers - 07/04/2023 - by Keirnan LaMarche, David Trinkle, Brian Zacour, Sherif Badawy
    An increasingly utilized model for the compaction process in the pharmaceutical industry is the Drucker-Prager Cap model (DPC). Historically, it has been employed in conjunction with finite element methods to …
    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Papers - 05/04/2023 - by Pauline H.M. Janssen, Sara Fathollahi, Bram Bekaert, Dirk Vanderroost, Timo Roelofs, Valerie Vanhoorne, Chris Vervaet, Bastiaan H.J. Dickhoff
    This paper demonstrates the influence of excipient properties on both process parameters and the ultimate tablet properties in a fully integrated continuous direct compression line. The blend properties of low-dose …