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Tableting of fluidized bed granules containing living microorganisms

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Tablets stand out as the preferred dosage form for numerous active pharmaceutical ingredients due to their ease of administration, secure dosing, and cost-effective large-scale production. This form is frequently selected for delivering viable probiotic microorganisms as well. In this study, Saccharomyces cerevisiae cells, granulated using a fluidized bed process with dicalcium phosphate (DCP), lactose (LAC), and microcrystalline cellulose (MCC) as carrier materials, underwent tabletting using a compaction simulator with variations in compression stress. The tablets underwent analysis for physical properties, including porosity and tensile strength, along with microbial survival. The study revealed that the choice of carrier material and the applied compression stress significantly influenced both the survival rate of microorganisms and the physical properties of the tablets. These dependencies were found to be associated with material-specific deformation characteristics and were linked to mechanistic approaches aimed at explaining the observed variations in sensitivities.
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Tableting of fluidized bed granules containing living microorganisms

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