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    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

    Papers - 25/01/2024 - by Dongyue Yu, Haichen Nie, Stephen W. Hoag
    The amorphous solid dispersion (ASD) method is a well-established approach to enhance the solubility and bioavailability of poorly soluble drugs. Although a significant number of ASD products are in tablet …
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    Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models

    Papers - 25/07/2023 - by Vincent Mazel, Jérémie Girardot, Jean-Benoit Kopp, Stéphane Morel, Pierre Tchoreloff
    The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature …
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    Enhanced multi-component model to consider the lubricant effect on compressibility and compactibility

    Papers - 04/04/2023 - by Daniel Puckhaber, Anna-Lena Voges, Supriya Rane, Sarah David, Bindhumadhavan Gururajan, Jan Henrik Finke, Arno Kwade
    Modeling the structural and mechanical properties of tablets composed of multiple components, based on a minimal amount of experimental data, is of great interest to minimize the time and cost …
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    Novel drug-loaded paper tablets for improved oral drug delivery

    Papers - 01/02/2023 - by Ayat Abdelkader Mohamed Aboelela
    The preferred route for drug administration is oral, and tablets stand out as the most prominent oral dosage form due to their advantages in dose precision, stability, simplicity, cost-effectiveness, and …
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    Tablets Made from Paper - An Industrially Feasible Approach

    Papers - 27/09/2022 - by Ayat Abdelkader, Christoph Moos, Adrien Pelloux, Marcus Pfeiffer, Christian Alter, Stefan Kolling, Cornelia Keck
    Numerous orally administered drugs face challenges in bioavailability due to limited solubility. The smartFilm technology presents an innovative solution for enhancing drug aqueous solubility by incorporating the drug into the …
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    Studies on the influence of high-shear granulation process on the compressibility of microcrystalline cellulose

    Papers - 25/09/2022 - by Boyun Xiao, Jiaqi Zhang, Lixin Geng, Xing Tang, Yanjiao Wang, Tian Yin, Yu Zhang, Jingxin Gou, Haibing He
    Microcrystalline cellulose (MCC) serves as a diluent in the formulation of oral solid dosage forms. In this predictive study, the wet granulation process was chosen to produce tablets containing losartan …
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    The effect of granules characters on mechanical properties of press-coated tablets: A comparative study

    Papers - 25/08/2022 - by Peifu Xiao, Yibin Guo, Jiahui Wang, Hongbing Liu, JiaXin Zhang, YanJiao Wang, Tian Yin, Yu Zhang, Jingxin Gou, Haibing He, Xing Tang
    The objective of this study was to examine the relationship between crucial granule characteristics (including particle size, surface roughness, and apparent porosity) and the mechanical properties of press-coated tablets. Granules …
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    Use of jump-tests for the characterization of the viscoplastic behavior of pharmaceutical powders during compaction

    Papers - 19/04/2022 - by Léo Desbois, Pierre Tchoreloff, Vincent Mazel
    Strain rate sensitivity (SRS) refers to how the compaction kinematics influence powder behavior during compaction and the resulting tablet properties. Various physical phenomena, such as viscoelasticity or viscoplasticity, can elucidate …
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    Predictive modelling of powder compaction for binary mixtures using the finite element method

    Papers - 12/04/2022 - by Dingeman L.H. van der Haven, Frederik H. ørtoft, Kaisa Naelapää, Ioannis S. Fragkopoulos, James A. Elliott
    In the pharmaceutical industry, the formulation of tablets remains a challenging task despite the widespread adoption of solid-form drug delivery. This challenge arises from the strong dependence of tablet properties …
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    Prediction of the impact of lubrication on tablet compactibility

    Papers - 05/04/2022 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Mauro Serratoni, Umair Zafar, Edgar John, Michael Juhnke, Arno Kwade
    The tableting process for most pharmaceutical formulations necessitates the incorporation of lubricants to mitigate ejection forces, prevent tooling damage, and address tablet defects. However, the internal addition of lubricants is …
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    Breaking patterns of press-coated tablets during the diametral compression test: Influence of the product, geometry and process parameters

    Papers - 25/01/2022 - by Léo Picart, Vincent Mazel, Aline Moulin, Vanessa Bourgeaux, Pierre Tchoreloff
    Press-coated tablets are a highly regarded technology in chronopharmaceutics, particularly for modified release applications. At the industrial level, assessing mechanical resistance is of paramount importance during both the development and …
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    Use of impulse excitation technique for the characterization of the elastic anisotropy of pharmaceutical tablets

    Papers - 10/08/2021 - by J. Meynard, F. Amado-Becker, P. Tchoreloff, V. Mazel
    Capping and lamination are common defects encountered in the pharmaceutical tablet manufacturing process. Numerous studies have indicated that tablet anisotropy can contribute to the occurrence of such defects. This study …
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    Effects of compaction and storage conditions on stability of intravenous immunoglobulin - implication on developing oral tablets of biologics

    Papers - 26/05/2021 - by Yuwei Lu, Chenguang Wang, Bowen Jiang, Changquan Calvin Sun, Stephen W. Hoag
    Biological products, encompassing therapeutic proteins, vaccines, and cell-based therapeutics, are witnessing rapid growth in the global market. Monoclonal antibodies, in particular, constitute a substantial portion of the biologics market. When …
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    Impact of Incorporated Drugs on Material Properties of Amorphous Solid Dispersions

    Papers - 28/12/2020 - by Karsten Flügel, Katharina Schmidt, Lena Mareczek, Michael Gäbe, Robert Hennig, Markus Thommes
    Despite the widespread use of amorphous solid dispersions (ASD) for poorly water-soluble drugs in the market, the formulation development of ASDs remains challenging. In the process of developing novel drugs, …
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    Characterization and modeling of the viscoelasticity of pharmaceutical tablets

    Papers - 28/07/2020 - by Léo Desbois, Pierre Tchoreloff, Vincent Mazel
    The variation in compaction properties of powders with compaction speed, known as strain rate sensitivity (SRS), is a common occurrence in the pharmaceutical tablet manufacturing process. However, various phenomena, such …
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    Impact of structural relaxation on mechanical properties of amorphous polymers

    Papers - 20/07/2020 - by Karsten Flügel, Robert Hennig, Markus Thommes
    Fusion-based techniques, such as hot-melt extrusion, are commonly employed for the preparation of amorphous solid dispersions. However, the amorphous glass obtained through these methods is not in configurational equilibrium, leading …
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    Effect of the Curvature of the Punches on the Shape of the Interface and the Delamination Tendency of Bilayer Tablets

    Papers - 01/05/2017 - by Luca Castrati, Vincent Mazel, Harona Diarra, Virginie Busignies, Pierre Tchoreloff
    Bilayer tablets hold special significance in the pharmaceutical industry, and a primary challenge in their manufacturing is the occurrence of delamination during or after ejection from the die. This study …
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    Press-coated tablets increased knowledge through research

    Bulletins - 01/01/2017 -
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    Impact of micromeritic properties of an active pharmaceutical ingredient on its compaction behavior

    Papers - 17/02/2015 - by Dilbir S. Bindra, Sridhar Desikan
    The processability of a high drug loading formulation can be notably influenced by the physical characteristics of an active pharmaceutical ingredient (API). This paper illustrates a case where distinct micromeritic …
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    On the links between elastic constants and effective elastic behavior of pharmaceutical compacts: importance of poisson's ratio and use of bulk modulus

    Papers - 01/11/2013 - by Vincent Mazel, Virginie Busignies, Harona Diarra, Pierre Tchoreloff
    The elastic properties of pharmaceutical powders and compacts play a crucial role in comprehending the intricate phenomena occurring during and after the tableting process. Elastic recovery following compression is known …