Scientific papers
This comprehensive review examines both modern and traditional granulation techniques in pharmaceutical dosage forms, with a particular focus on dry and wet granulation. The dry granulation methods covered include slugging, roller compaction, and pneumatic dry granulation, each analyzed in detail regarding their processing methods, benefits, drawbacks, and various applications. The article also explores eleven wet granulation techniques, providing insights into high-shear granulation, low-shear granulation, fluidized bed granulation, reverse wet granulation, steam granulation, moisture-activated dry granulation, melt granulation, freeze-dry granulation, foam granulation, thermal adhesion, and twin screw wet granulation. Each technique is thoroughly examined, highlighting its processing steps, advantages, disadvantages, and practical applications in pharmaceutical manufacturing. This review serves as a valuable resource for researchers, pharmaceutical professionals, and students, offering an in-depth exploration of essential granulation techniques in drug formulation. The synthesis of information aims to improve understanding of granulation processes, aiding informed decision-making in pharmaceutical development and manufacturing.
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