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    Image Hot-Melt extrusion - from theory to application in pharmaceutical formulation - where are we now

    Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We Now?

    Newsfeeds - 10/04/2024 -
    Hot-melt extrusion (HME) stands as a widely acknowledged and robust technology, effectively enhancing the bioavailability of poorly soluble active pharmaceutical ingredients while offering an efficient continuous manufacturing process. The twin-screw …
    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Papers - 25/03/2024 - by Adwait Pradhan, Brian Phillips, Fengyuan Yang, Kapish Karan, Thomas Durig, Brian Haight, Charlie Martin, Feng Zhang
    Twin-screw melt granulation (TSMG) relies on both dispersive and distributive mixing at the kneading zone to facilitate granule growth, underscoring the pivotal role played by kneading elements in TSMG. Despite …
    Yellow tablets iStock-1218616175

    Flexible granulation

    Newsfeeds - 20/02/2024 -
    The process of pharmaceutical granulation plays a pivotal role in producing solid dosage forms, directly influencing the efficacy, stability, and overall quality of the drug. Within pharmaceutical manufacturing, flexible granulation …
    MUPS KORSCH technology blog

    MUPS - the mixture is what matters

    White Papers - 06/02/2024 - by Friederike Guetter
    MUPS, or “multiple unit pellet system”, is a solid dosage form in which the granulation consists of a mixure of active, coated pellets and powder excipients. MUPS products include, for …
    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Papers - 22/08/2023 - by Pankaj Bhatt, Vipin Kumar, Harsh Rastogi, Mayank Kumar Malik, Raghav Dixit, Sakshi Garg, Garima Kapoor, Suruchi Singh
    The functional and tableting characteristics of barnyard millet starch (Echinochloa esculenta) were examined in its native (alkali-treated) and chemically modified (phosphorylated) forms. The grains underwent pulverization, soaking, and grinding before …
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    A REVIEW ON FORMULATION OF EFFERVESCENT TABLET

    Papers - 01/04/2023 -
    The effervescent tablets are formulated by various methods like wet granulation and dry granulation. One of the most popular ways of administering a medicament is by converting it to its …
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    An introduction to spheronization (or marumerization)

    White Papers - 14/02/2023 -
    Spheronization (or marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 …
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    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Papers - 25/07/2022 - by Shang Jun Loo, Paul Wan Sia Heng, Lai Wah Chan
    Micronized drug powders are often impractical for use as tableting feed to create minitablets due to their cohesiveness and poor flow properties. The addition of fumed silica (fSi) within an …
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    Assess the impact of your granulation process parameters with the STYL'One Evo

    Bulletins - 01/03/2022 - by Sixtine Caquant, Adrien Pelloux
    Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient …
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    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Papers - 01/06/2020 - by V. Vanhoorne, R. Almey, T. De Beer, C. Vervaet
    In this present study, we explored whether the moisture-mediated polymorphic transition from δ- to β-mannitol observed during twin screw granulation (TSG) could occur in formulations with a high drug load. …
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    Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process

    Papers - 16/04/2020 - by Martin Wewers, Stefan Czyz, Jan Henrik Finke, Edgar John, Bernard Van Eerdenbrugh, Michael Juhnke, Heike Bunjes, Arno Kwade
    Reducing the particle size of active pharmaceutical ingredients is an efficient strategy for addressing challenges related to poor aqueous solubility. To enhance stability and patient convenience, nanosuspensions are often converted …
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    Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

    Papers - 01/09/2019 - by A. Saker, M.-G. Cares-Pacheco, P. Marchal, V. Falk
    This study evaluates powder flowability during granular compaction under free surface conditions, utilizing the Hausner ratio (HR) as the flowability index. Various pharmaceutical and food powders were scrutinized using three …
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    Tricalcium citrate – a new brittle tableting excipient for direct compression and dry granulation with enormous hardness yield

    Papers - 04/07/2018 - by Veronika Hagelstein, Markus Gerhart, Karl G. Wagner
    Objective: This study is dedicated to characterizing tricalcium citrate (TCC) as a tableting excipient, examining its suitability for both direct compression (DC) and dry granulation (DG). Significance: Tablets crafted from …
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    Enhancing tablet disintegration characteristics of a highly water-soluble high-drug-loading formulation by granulation process

    Papers - 03/07/2018 - by Preetanshu Pandey, Christopher Levins, Steve Pafiakis, Brian Zacour, Dilbir S. Bindra, Jade Trinh, David Buckley, Shruti Gour, Shasad Sharif, Howard Stamato
    The aim of this investigation was to enhance the disintegration and dissolution characteristics of a highly water-soluble tablet matrix by modifying the manufacturing process. For a high drug loading (70% …
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    How Deformation Behavior Controls Product Performance After Twin Screw Granulation With High Drug Loads and Crospovidone as Disintegrant

    Papers - 03/11/2016 - by Robin Meier, Klaus-Peter Moll, Markus Krumme, Peter Kleinebudde
    This study explores the quantitative impact of 12 different materials (including active pharmaceutical ingredients and excipients as surrogate active pharmaceutical ingredients) on the critical quality attributes of products generated through …
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    Evaluating Scale-Up Rules of a High-Shear Wet Granulation Process

    Papers - 01/07/2015 - by Jing Tao, Preetanshu Pandey, Dilbir S. Bindra, Julia Z. Gao, Ajit S. Narang
    This study aimed to assess the applicability of commonly employed scale-up rules for the high-shear wet granulation process, utilizing a formulation with low drug loading based on microcrystalline cellulose-lactose. Various …
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    Mechanistic Insights into the Scale‐Up of the Roller Compaction Process: A Practical and Dimensionless Approach

    Papers - 01/10/2013 - by Jasmine M. Rowe, John R. Crison, Thomas J. Carragher, Nipa Vatsaraj, Ryan J. Mccann, Faranak Nikfar
    While the roller compaction process may seem straightforward, attempts to quantitatively model the process have been challenging due to the complex behavior of materials in the feeding and compaction zones. …