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Worsened punch sticking by external lubrication with magnesium stearate

Worsened punch sticking by external lubrication with magnesium stearate

Papers - 01/01/2024 - by Tianyi Xiang, Changquan Calvin Sun
Applying magnesium stearate (MgSt) as an external lubricant to tooling is a widely used approach to prevent punch sticking during the compression of powders with a high tendency to stick, …
Upscaling of external lubrication from a compaction simulator to a rotary tablet press

Upscaling of external lubrication from a compaction simulator to a rotary tablet press

Papers - 01/01/2023 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with …
Screening of lubricants towards their applicability for external lubrication

Screening of lubricants towards their applicability for external lubrication

Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …
Effect of binder type and lubrication method on the binder efficacy for direct compression

Effect of binder type and lubrication method on the binder efficacy for direct compression

Papers - 25/09/2021 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
1. Introduction: The incorporation of a binder into a direct compression formulation aims to enhance tablet tensile strength and mitigate tablet defects. The internal blending of magnesium stearate (MgSt) is …
20210217_Webinar_External_lubircation_on_STYL'One_Evo - Medelpharm + Cedrine

How to mitigate the impact of lubricants on your quality attributes

Webinar Replays - 11/02/2021 - by Cedrine De Backere, Bruno Leclercq
Cedrine de Backere (Gent University) highlights different aspects of lubrication. Evaluation of an external lubrication system on a STYL'One Evo, influence of process parameters and comparison with internal lubrication.
Evaluation of an external lubrication system implemented in a compaction simulator

Evaluation of an external lubrication system implemented in a compaction simulator

Papers - 25/09/2020 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
The internal blending of magnesium stearate is often linked to a reduction in tensile strengths and extended disintegration and dissolution times. Consequently, external lubrication has gained attention in the pharmaceutical …
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Evaluation of the performance of an external lubrication system implemented in a compaction simulator

Papers - 01/09/2018 - by Cedrine de Backere, Valerie Vanhoorne, Chris Vervaet
The application of internal lubrication is commonly linked to a reduction in tensile strengths and an increase in disintegration times. In contrast, external lubrication involves spraying the lubricant onto tablet …
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External lubrication system on the Styl’One Evolution

Papers - 22/02/2018 - by Cedrine de Backere, Valérie Vanhoorne, Chris Vervaet
Objectives: 1. Examine the comprehensive functionality of the external lubrication system integrated into the Styl’One Evolution. 2. Define the critical process parameters (CPPs) influencing the critical quality attributes (CQAs) of …