Scientific papers
Applying magnesium stearate (MgSt) as an external lubricant to tooling is a widely used approach to prevent punch sticking during the compression of powders with a high tendency to stick, including various pure active pharmaceutical ingredients (APIs). Surprisingly, our findings revealed that this method resulted in increased punch sticking under low compaction pressures. This unexpected occurrence was elucidated by considering the interactions among the punch tip, MgSt, and API forces. The explanation is substantiated by the observed impact of pressure and mechanical properties of APIs on this phenomenon.
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