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Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

Effect of particle size on the dispersion behavior of magnesium stearate blended with microcrystalline cellulose

Papers - 07/01/2024 - by Daniel Puckhaber, Jan Henrik Finke, Sarah David, Bindhumadhavan Gururajan, Supriya Rane, Arno Kwade
Most tablets produced include lubricants to minimize friction during ejection. However, in the case of plastically deforming materials such as microcrystalline cellulose (MCC), internal incorporation of lubricants is known to …
Worsened punch sticking by external lubrication with magnesium stearate

Worsened punch sticking by external lubrication with magnesium stearate

Papers - 01/01/2024 - by Tianyi Xiang, Changquan Calvin Sun
Applying magnesium stearate (MgSt) as an external lubricant to tooling is a widely used approach to prevent punch sticking during the compression of powders with a high tendency to stick, …
Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

Impact of magnesium stearate physical and chemical variabilities on pharmaceutical powder flow and tablet physical properties

Papers - 08/12/2023 - by Natalia Veronica, Yi Ying Loh, Lydia Xiu Ying Loh, Paul Wan Sia Heng, Celine Valeria Liew
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Effects of tableting process parameters and powder lubrication levels on tablet surface temperature and moisture content

Papers - 08/11/2023 - by Komlan Koumbogle, Ryan Gosselin, François Gitzhofer, Nicolas Abatzoglou
The occurrence of punch sticking poses a recurrent challenge in the pharmaceutical tablet manufacturing process. The moisture content of the powder plays a crucial role in the development of sticking; …
Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

Understanding the role of magnesium stearate in lowering punch sticking propensity of drugs during compression

Papers - 06/05/2023 - by Chamara A. Gunawardana, Angela Kong, Debbie Wanapun, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, John E. Kresevic, Changquan Calvin Sun
The adherence of active pharmaceutical ingredient (API) to compaction tooling surfaces, commonly known as punch sticking, can lead to costly downtime or product failures during commercial tablet manufacturing. Magnesium stearate …
Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental mapping

Magnesium stearate surface coverage on tablets and drug crystals: Insights from SEM-EDS elemental mapping

Papers - 10/01/2023 - by Chamara A. Gunawardana, Angela Kong, Daniel O. Blackwood, C. Travis Powell, Joseph F. Krzyzaniak, Myles C. Thomas, Changquan Calvin Sun
We propose the utilization of scanning electron microscopy-based energy dispersive X-ray spectroscopy (SEM-EDS) as a versatile tool for quantifying surface area coverage (SAC) by magnesium stearate (MgSt) on pharmaceutical tablets …
Upscaling of external lubrication from a compaction simulator to a rotary tablet press

Upscaling of external lubrication from a compaction simulator to a rotary tablet press

Papers - 01/01/2023 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
External lubrication is a highly valuable alternative lubrication method as it minimizes the negative impact on tablet properties encountered when using internal lubrication. In current study, experiments were performed with …
Screening of lubricants towards their applicability for external lubrication

Screening of lubricants towards their applicability for external lubrication

Papers - 28/12/2022 - by Cedrine de Backere, Margot Surmont, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
Decreasing tensile strength and prolonged disintegration are linked to internal lubrication. These adverse effects can be mitigated by employing external lubrication. In this present investigation, a compaction simulator was utilized …
Impact of Lubrication on Key Properties of Orodispersible Minitablets in Comparison to Conventionally Sized Orodispersible Tablets

Impact of lubrication on key properties of orodispersible minitablets in comparison to conventionally sized orodispersible tablets

Papers - 05/09/2022 - by Jennifer Kuck, Jörg Breitkreutz
Orodispersible minitablets (ODMTs) offer several advantages such as ease of swallowability, dose flexibility, and straightforward manufacturing through direct compression. This study investigates the impact of lubrication on five different co-processed …
The Overview of Oral Solid Dosage Forms and Different Excipients Used for Solid Dosage Formulation

The overview of oral solid dosage forms and different excipients used for solid dosage formulation

Papers - 24/08/2022 - by Ms. Kiran Rameshbhai Dudhat
In the development of pharmaceutical dosage forms, the choice of excipients plays a pivotal role in both preformulation and formulation research. The physical, mechanical, and chemical attributes of excipients exert …
Impact of alternative lubricants on process and tablet quality for direct compression

Impact of alternative lubricants on process and tablet quality for direct compression

Papers - 14/07/2022 - by Cedrine de Backere, Julian Quodbach, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
In this study, the utilization of magnesium stearate (MgSt) as an internal lubricant has been linked to a decrease in tensile strength and prolonged disintegration and dissolution times. The current …
Lubrication-now-easy-to-use-for-RD-lab-environm.original

Lubrication now easy-to-use for R&D lab environment

White Papers - 02/07/2021 - by Bruno Leclercq
Lubricants are often required to minimize friction between a tablet surface and the die walls during the ejection phase of the compression cycle. In turn the reduced friction minimizes the …
Evaluation of an external lubrication system implemented in a compaction simulator

Evaluation of an external lubrication system implemented in a compaction simulator

Papers - 25/09/2020 - by Cedrine de Backere, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
The internal blending of magnesium stearate is often linked to a reduction in tensile strengths and extended disintegration and dissolution times. Consequently, external lubrication has gained attention in the pharmaceutical …
Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

Biopharmaceutical implications of excipient variability on drug dissolution from immediate release products

Papers - 16/07/2020 - by P. Zarmpi, T. Flanagan, E. Meehan, J. Mann, J. Østergaard, N. Fotaki
Examining the influence of excipient variability on oral product performance from a biopharmaceutical perspective could be advantageous and facilitate the integration of excipients into Quality by Design (QbD) approaches. The …
Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

Effect of friction between powder and tooling on the die-wall pressure evolution during tableting: Experimental and numerical results for flat and concave punches

Papers - 01/01/2019 - by V. Mazel, H. Diarra, P. Tchoreloff
The final properties of tablets are predominantly determined during the compaction process by the development of stresses applied to the powder. Any parameter related to the process or product that …
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Evaluation of the performance of an external lubrication system implemented in a compaction simulator

Papers - 01/09/2018 - by Cedrine de Backere, Valerie Vanhoorne, Chris Vervaet
The application of internal lubrication is commonly linked to a reduction in tensile strengths and an increase in disintegration times. In contrast, external lubrication involves spraying the lubricant onto tablet …
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External lubrication system on the Styl’One Evolution

Papers - 22/02/2018 - by Cedrine de Backere, Valérie Vanhoorne, Chris Vervaet
Objectives: 1. Examine the comprehensive functionality of the external lubrication system integrated into the Styl’One Evolution. 2. Define the critical process parameters (CPPs) influencing the critical quality attributes (CQAs) of …
White single-layer tablets on yellow background

Impact of moisture and magnesium stearate functionality on manufacturability of wet granulated metformin tablets

Papers - 18/08/2017 - by Umesh Kestur, Divyakant Desai, Shasad Sharif, Benjamin Wong, Hang Guo, Dan Tang, Steven Chan
Throughout the development of an 850 mg metformin hydrochloride tablet formulation using wet granulation, the tablets consistently displayed elevated friability levels (>3% w/w) regardless of the origin of extra-granular …