Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation
first_published_at:June 1, 2020, midnight / date_published:June 1, 2020
Papers
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01/06/2020 -
by
V. Vanhoorne,
R. Almey,
T. De Beer,
C. Vervaet
In this present study, we explored whether the moisture-mediated polymorphic transition from δ- to β-mannitol observed during twin screw granulation (TSG) could occur in formulations with a high drug load. …
