Surfactant-mediated dissolution of metformin hydrochloride tablets: wetting effects versus ion pairs diffusivity
first_published_at:March 1, 2014, midnight / date_published:March 1, 2014
Papers
-
01/03/2014 -
by
Divyakant Desai,
Benjamin Wong,
Yande Huang,
Qingmei Ye,
Dan Tang,
Hang Guo,
Ming Huang,
Peter Timmins
The aqueous solubility of metformin (pKa: 2.8 and 11.5) within the pH range of 1.2–6.8 is 300 mg/mL, suggesting that the dissolution of metformin hydrochloride tablets should exhibit pH independence. …
