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726 results

2 results

Date

Evaluation of the effect of granule size of raw tableting materials on critical quality attributes of tablets during the continuous tablet manufacturing process using near-infrared spectroscopy
in Papers - Makoto Otsuka, Tokiro Ogata, Yusuke Hattori, Tetsuo Sasaki.
The impact of granule size variation in raw materials on tablet hardness (TH) and weight (TW) within the continuous tabl...
The ubiquity of the tabletability flip phenomenon
in Papers - Zijian Wang, Chenguang Wang, Deepak Bahl, Changquan Calvin Sun.
The malleability of materials plays a crucial role in achieving effective powder tabletability, a key factor in the deve...
Choosing the correct tool material specification
in White papers - 14/12/2023 - n/a
Michael Oxford, Research and Design Engineer at I Holland explains how I Holland recently helped pharma group Accord Hea...
Consolidation of spray-dried amorphous Calcium Phosphate by ultrafast compression: chemical and structural overview
in Papers - Sylvain Le Grill, Christophe Drouet, Olivier Marsan, Yannick Coppel, Vincent Mazel, Marie-Claire Barthelemy, Fabien Brouillet.
A significant portion of research within the orthopedic and maxillofacial fields is devoted to advancing bioactive 3D sc...
Improving active pharmaceutical ingredient formulation by hot melt extrusion
in Newsfeeds - 10/06/2024 - n/a
This poster, presented at the PBP World Meeting 2024 in Vienna, explores the integration of AI and big data in pharmaceu...
Tooling terminology
in Bulletins - none
All what you need to know about the size & format of Punches & Dies. Some terminology such as D, B, 441, EU, TSM...
Processing challenges with solid dosage formulations containing vitamin E TPGS
in Papers - Preetanshu Pandey, Patrick D. Sinko, Dilbir S. Bindra, Rhye Hamey, Shruti Gour, Chandra Vema-Varapu.
This study aims to explore the challenges associated with incorporating Vitamin E TPGS (d-α tocopheryl polyethylene glyc...
A combined experimental and modeling approach to study the effects of high-shear wet granulation process parameters on granule characteristics
in Papers - Preetanshu Pandey, Jing Tao, Anwesha Chaudhury, Rohit Ramachandran, Julia Z. Gao, Dilbir S. Bindra.
The current study aims to investigate the impact of high-shear wet granulation process parameters on granule characteris...
The role of continuous manufacturing in large-batch production
in Newsfeeds - 25/03/2024 - n/a
The text discusses the potential of Continuous Manufacturing as a production organization for pharmaceuticals, particula...
Ebook: Twin-screw extrusion for pharmaceutical applications
in Newsfeeds - 03/07/2024 - n/a
This compendium provides a comprehensive guide on how hot-melt extrusion (HME) can address common challenges in pharmace...
Influence of layer composition and compaction parameters on the manufacturing of sucralfate/ibuprofen lysine bi-layer tablets
in Papers - Alessandra Rossi, Matteo Molinari, Fabiola Lombardi, Luca Castrati, Dimitrios Rekkas, Stavros Politis, Ruggero Bettini, Paolo Colombo.
Investigation into the impact of layer composition and compaction parameters on the tendency of delamination in bi-layer...
A powder tabletability equation
in Posters - Gerrit Vreeman, Changquan Calvin Sun.
A mathematical expression delineating the relationship between the tensile strength of tablets and compaction pressure w...
Swift single step scale-up from compaction simulator to production rotary press
in Papers - Moritz Rosch, Friederike Gütter.
The scale up process of tablets can be influenced by many factors that can occur during process development. The develop...
Systems engineering for high containment
in White papers - 27/03/2024 - Johannes Nitzsche
Planning a fully integrated tablet compression system for high-containment requires extensive know-how and experience. “...
Manufacturing equipment trends
in Newsfeeds - 30/04/2024 - n/a
The text provides an overview of pharmaceutical and biopharmaceutical manufacturing processes, emphasizing the need for ...
Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior
in Papers - Adwait Pradhan, Brian Phillips, Fengyuan Yang, Kapish Karan, Thomas Durig, Brian Haight, Charlie Martin, Feng Zhang.
Twin-screw melt granulation (TSMG) relies on both dispersive and distributive mixing at the kneading zone to facilitate ...
Understanding the factors that control the quality of mini-tablet compression: flow, particle size, and tooling dimension
in Papers - Junshu Zhao, David Yin, Jasmine Rowe, Sherif Badawy, Faranak Nikfar, Preetanshu Pandey.
Despite the growing significance of mini-tablets for their advantages in pediatric formulations and modified-release app...
Radial die wall pressure measurement
in Bulletins - Delphine Ach-Hubert, Adrien Pelloux.
During tablet development, people study ejection forces (Fej) in order to avoid tablet defects during tablet manufacturi...
The performance of PROSOLV EASYtab SP in four medium-dose, direct compression formulations with morphologically challenging model APIs
in Bulletins - none
In the present study, the performance of PROSOLV EASYtab SP was tested in four DC formulations with different model APIs...
STYL’One Evolution / Industrial rotary press correlation study on a tab-in-tab dosage form
in Bulletins - Aline Moulin.
These case studies were presented by SKYEPHARMA during CSF Cambridge 2018 to highlight the development of multilayer and...

Tablet disintegration and dispersion under in vivo-like hydrodynamic conditions

Tablet disintegration and dispersion under in vivo-like hydrodynamic conditions

first_published_at:Jan. 16, 2022, midnight / date_published:Jan. 16, 2022

Papers - 16/01/2022 - by Jan Lenz, Frederik Fuest, Jan Henrik Finke, Heike Bunjes, Arno Kwade, Michael Juhnke

Disintegration and dispersion are crucial functional properties of tablets, playing a key role in achieving the desired release of the active pharmaceutical ingredient (API). The standard disintegration test (SDT), as …

Tablet formulation development focusing on the functional behaviour of water uptake and swelling

Tablet formulation development focusing on the functional behaviour of water uptake and swelling

first_published_at:Dec. 1, 2021, midnight / date_published:Dec. 1, 2021

Papers - 01/12/2021 - by Jan Lenz, Jan Henrik Finke, Heike Bunjes, Arno Kwade, Michael Juhnke

The functional characteristics of tablets are significantly shaped by the manufacturing process and the selection of excipients. Water uptake and swelling play crucial roles in tablet disintegration, dispersion, and subsequently, …

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