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    tablet white

    Using the STYL'One Nano compaction simulator to characterise round and oblong itraconazole amorphous solid dispersions tablets

    Bulletins - 05/03/2023 - by Hetvi Triboandas, Mariana Bezerra, Walkiria Schlindwein
    Itraconazole (ITZ) is an antifungal drug commercially available as an oral solution or more commonly as 100 mg capsules. It has been reported that the bioavailability of the oral solution …
    design of experiment

    Design of Experiments (DoE) An essential tool to better understand tablet formulations

    Bulletins - 01/03/2023 - by Mariana Bezerra, Hetvi Triboandas, Walkiria Schlindwein
    This paper covers a brief overview of the steps for pharmaceutical product development under the quality by design (QbD) framework; introduces design of experiments (DoE) applied to formulation of tablets …
    compaction characterisation

    Compaction characterisation of piroxicam amorphous solid dispersions formulations

    Bulletins - 05/02/2023 - by Mariana Bezerra, Hetvi Triboandas, Walkiria Schlindwein
    Amorphous solid dispersions (ASDs) have been widely used to improve the bioavailability of poorly water-soluble drugs [1]. They are comprised of high molar mass polymer carriers that stabilise the active …
    tablet white powder

    Formulation development and compaction of itraconazole amorphous solid dispersions tablets using quality by design principles

    Bulletins - 02/01/2023 - by Hetvi Triboandas, Mariana Bezerra, Walkiria Schlindwein
    Itraconazole (ITZ), a BCS Class II drug exhibiting low solubility (1-4 ng/mL in water) requires formulation enhancement to achieve enhanced bioavailability. To tackle this problem amorphous solid dispersions (ASDS) of …
    Accelerated technology transfer for the development of fexuprazan using compaction simulation

    Accelerated technology transfer for the development of fexuprazan using compaction simulation

    Posters - 04/11/2022 - by Sanjay Konagurthu, Jignesh Patel, Arasu Kondappan, Ryan Minikis, Peyman Aminpour
    Accelerated technology transfer for the development of fexuprazan using compaction simulation

    Accelerated technology transfer for the development of fexuprazan using compaction simulation

    Papers - 04/11/2022 - by Sanjay Konagurthu, Jignesh Patel, Arasu Kondappan, Ryan Minikis, Peyman Aminpour
    Effect of die taper and precompression on air entrapment during tablet compression

    Effect of die taper and precompression on air entrapment during tablet compression

    Papers - 03/11/2022 - by Gerrit Vreeman, Mehrdad Kheiripour Langroudi, Bhavesh Barot, Cletus Nunes, Rahul Manek, Yai Sartnurak, Changquan Calvin Sun
    During tablet compression, the presence of trapped air can significantly compromise both the visual appeal and mechanical characteristics of the tablet. Factors such as low-clearance tooling, elevated powder plasticity, and …
    no-image

    A powder tabletability equation

    Posters - 01/11/2022 - by Gerrit Vreeman, Changquan Calvin Sun
    A mathematical expression delineating the relationship between the tensile strength of tablets and compaction pressure was formulated using the equations initially suggested by Ryshkewitch and Kuentz-Leuenberger. This equation was applied …
    no-image

    A powder tabletability equation

    Papers - 01/11/2022 -
    A mathematical expression delineating the relationship between the tensile strength of tablets and compaction pressure was formulated using the equations initially suggested by Ryshkewitch and Kuentz-Leuenberger. This equation was applied …
    Development of an automated microscale manufacturing system for oral solid dosage forms

    Development of an automated microscale manufacturing system for oral solid dosage forms

    Papers - 20/06/2022 - by J Moores, F Abbas, M Salehian, D Markl, C Macleod, S G Pierce
    Platform II employs artificial intelligence (AI) to establish an autonomous workflow for the manufacturing and testing of drug products. It achieves this by identifying critical material attributes (CMAs) and their …
    no-image

    AI-assisted optimization of oral solid dosage form development

    Papers - 20/06/2022 - by M Salehian, J Moores, F Abbas, D Markl
    Platform II employs artificial intelligence (AI) to establish an autonomous workflow for the manufacturing and testing of drug products. It achieves this by identifying critical material attributes (CMAs) and their …
    capping

    Effect of precompresion on capping tendency

    Bulletins - 06/04/2022 - by Sixtine Caquant
    Compaction simulators are a key technology allowing scientists to develop formulations and troubleshoot tablet defects. It means that formulation scientists or tech transfer engineers can assess the influence of process …
    Nano_on_table_Medelpharm logo

    Material characterization with a V-shape compression profile on STYL'One Nano

    Bulletins - 01/08/2021 - by Sixtine Caquant, Quentin Boulay
    In the early stages of drug development, APIs are often available in limited amount. However, scientists have to foresee the impact of compaction parameters on tablet attributes. In fact, tablet …
    Material characterization with extended dwell time - bulletin

    Material characterization with extended dwell time compression profile on STYL'One Nano

    Bulletins - 01/05/2021 - by Quentin Boulay, Sixtine Caquant
    During the development of a new drug, active materials are often available in small quantities for cost or process reasons. However, scientists have to understand their deformation behavior to design …
    no-image

    Material characterisation on STYL'One Nano

    Bulletins - 02/02/2017 -
    Excipients, APIs or formulations can be processed in different ways, thus resulting in different properties. Research has been performed to improve powder properties including powder flow, powder density, particle size …