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Effect of die taper and precompression on air entrapment during tablet compression

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During tablet compression, the presence of trapped air can significantly compromise both the visual appeal and mechanical characteristics of the tablet. Factors such as low-clearance tooling, elevated powder plasticity, and the absence of a deaeration step can worsen problems associated with air entrapment. To address issues related to air entrapment and reduce lamination defects, common practices include employing a tapered die and implementing a precompression step. It is essential to conduct a comparative analysis between die tapering and precompression to evaluate their effectiveness in mitigating air entrapment problems, especially in formulations with high plasticity that are prone to such issues.
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