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    Discerning excipient functionality: Lubricants vs. anti-adherents

    Discerning excipient functionality: Lubricants vs. anti-adherents

    Papers - 01/10/2025 - by Tianyi Xiang, Changquan Calvin Sun
    Excipients play a critical role in tablet manufacturing, contributing to both formulation performance and process efficiency. Among them, lubricants and anti-adherents serve distinct functions, though these roles are often mistakenly …
    Formulation optimization of ritonavir tablets containing spray dried dispersion from HPMCAS-L or PVP-VA and comparative dissolution/permeation performance

    Formulation optimization of ritonavir tablets containing spray dried dispersion from HPMCAS-L or PVP-VA and comparative dissolution/permeation performance

    Papers - 25/09/2025 - by Ayse Nur Oktay, James E. Polli
    Tablets remain the most widely used oral dosage form, valued for their rapid production, cost efficiency, stability, and patient adherence. Amorphous solid dispersions (ASDs) are a proven strategy to enhance …
    Multiple Unit Pellet System

    Multiple Unit Pellet System

    Bulletins - 16/07/2025 - by Friederike Guetter
    The development of pharmaceutical dosage forms continuously seeks innovative approaches to enhance drug delivery, therapeutic efficiency, and patient compliance. Multiple-unit pellet systems (MUPS) have emerged as sophisticated drug delivery platforms …
    Multi-tip tooling I Holand

    The ABCs of tablet tooling

    Newsfeeds - 30/04/2025 -
    The article covers essential factors in selecting and using tablet tooling for solid dose manufacturing. It discusses the importance of choosing the right steel for tooling, such as electroslag re-melted …
    Monash Uni pharma technology seminar (29)

    KORSCH & MEDELPHARM sharing expertise in tablet formulation and pharmaceutical technology at Monash University

    Newsfeeds - 28/04/2025 -
    The Pharmaceutical Technology Seminar at Monash University Malaysia offered in-depth presentations and practical training in tablet formulation—highlighting the power of academic and industry collaboration.
    Yellow and white tablets on pink background

    Determination of ribbon solid fraction in roll compaction using ibuprofen DC100

    Newsfeeds - 14/04/2025 -
    The study titled "Determination of Ribbon Solid Fraction in Roll Compaction using Ibuprofen DC100" focuses on developing a Process Analytical Technology (PAT) for in-line measurement of ribbon solid fraction during …
    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Papers - 15/11/2024 - by Vincent Mazel, Pierre Tchoreloff
    Relaxation tests are commonly used in the pharmaceutical industry to evaluate the strain rate sensitivity of powders and tablets. In these tests, a constant strain is applied to the powder …
    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    Papers - 28/10/2024 - by Yiwang Guo, Lizbeth Martinez, Arnesh Palanisamy, Bindhu Gururajan, Changquan Calvin Sun
    Ribbon porosity is essential to monitor in roller compaction. This study compares six porosity measurement methods—caliper, X-ray microtomography (µCT), near-infrared spectroscopy (NIR), laser triangulation, mercury intrusion porosimetry (MIP), and GeoPyc—using …
    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Newsfeeds - 22/10/2024 -
    The article discusses the critical importance of tablet weight uniformity in the tablet manufacturing process, emphasizing its role in ensuring that each tablet consistently delivers the intended dosage of key …
    assorted-pharmaceutical-tablets

    From technology selection to final drug product: material sparing approaches for asd development

    Newsfeeds - 04/10/2024 -
    Compounds with low solubility and poor bioavailability present ongoing challenges in pharmaceutical development. This webinar explores Lonza's ‘right first time’ strategy, which employs material-efficient and time-saving techniques to accelerate the …
    MEDELPHARM_CPHI_Nano_Demonstration

    MEDELPHARM and Armor Pharma collaborate for innovative formulation development at CPHI 2024

    Newsfeeds - 03/10/2024 -
    MEDELPHARM is excited to announce its participation at CPHI 2024 in Milan, exhibiting in collaboration with Armor Pharma, a leading manufacturer of pharmaceutical excipients. Together, they will present live demonstrations …
    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Papers - 15/08/2024 - by Dingeman L.H. Van Der Haven, René Jensen, Maria Mikoroni, Umair Zafar, James A. Elliott, Ioannis S. Fragkopoulos
    The magnitude of frictional forces during the ejection of porous pharmaceutical tablets is crucial in determining the likelihood of tabletting defects. In this study, we conduct a systematic comparison of …
    The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer

    The increase in the plasticity of microcrystalline cellulose spheres’ when loaded with a plasticizer

    Papers - 16/07/2024 - by Artūrs Paulausks, Tetiana Kolisnyk, Valentyn Mohylyuk
    Compaction pressure can cause undesirable effects in drugs such as solid-state polymorphic transitions, fragmentation, loss of coated pellet integrity, and reduced viability and vitality of microorganisms. To mitigate these effects, …
    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Papers - 04/07/2024 - by Julie Auffray, Hassana Hsein, Nicolas Biteau, Christophe Velours, Thierry Noel, Pierre Tchoreloff
    Among the various pharmaceutical forms, tablets provide numerous advantages, including ease of administration, cost-effectiveness in production, and enhanced stability of biomolecules. Additionally, tablets facilitate alternative routes for local delivery of …
    Image study - benefits of an optimal tabletability DC Mannitol on compression-resize

    Optimizing API load and minimizing tablet weight leveraging an innovative DC Mannitol

    Newsfeeds - 26/06/2024 -
    *INTRODUCTIONTablets with stability issues often utilize mannitol, a stable, water-soluble excipient. Direct compression is a preferred method for its simplicity and cost-effectiveness. However, directly compressible mannitol grades tend to cap …
    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Papers - 25/06/2024 - by Claudia Köster, Peter Kleinebudde
    This study examined the impact of hydroxypropyl cellulose (HPC) type (HPC-SSL SFP, HPC-SSL), binder concentration (2%, 3.5%, 5%), and filler type (lactose, or calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on …
    standard tablets on blue background

    Tablet manufacturing equipment is evolving

    Newsfeeds - 14/06/2024 -
    Tablet manufacturing equipment has evolved significantly due to the demands for business efficiency. Modern tablet presses are designed to make manufacturing faster, simpler, and more efficient, achieving higher tablet yields …
    Tablet_Minitablet_vs_tablet_1

    Development of mini-tablet and multi-unit pellet systems (MUPs)

    Newsfeeds - 24/05/2024 -
    The text discusses the development and benefits of Mini-Tablet and Multi-Unit Pellet Systems (MUPS) in oral drug delivery. These advanced dosage forms offer controlled and sustained release profiles, achieved through …
    Image - Choosing the optimal dosage form for your moleculex600

    Choosing the optimal dosage form for your molecule

    Newsfeeds - 22/04/2024 -
    There are many factors to consider when choosing the right oral dosage form for your active pharmaceutical ingredient (API) leading up to clinical trials, including:- Drug profile- Ease of formulation …
    Tablet_TabInTab-vs-Multilayer_8_centered

    Modified-release formulation strategies

    Newsfeeds - 31/01/2024 -
    The increasing popularity of modified-release (MR) dosage forms is attributed to the numerous therapeutic advantages they provide for both drug developers and patients. Oral MR formulations are specifically designed to …