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    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation

    Papers - 15/11/2024 - by Vincent Mazel, Pierre Tchoreloff
    Relaxation tests are commonly used in the pharmaceutical industry to evaluate the strain rate sensitivity of powders and tablets. In these tests, a constant strain is applied to the powder …
    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    An evaluation of six techniques for measuring porosity of ribbons produced by roller compaction

    Papers - 28/10/2024 - by Yiwang Guo, Lizbeth Martinez, Arnesh Palanisamy, Bindhu Gururajan, Changquan Calvin Sun
    Ribbon porosity is essential to monitor in roller compaction. This study compares six porosity measurement methods—caliper, X-ray microtomography (µCT), near-infrared spectroscopy (NIR), laser triangulation, mercury intrusion porosimetry (MIP), and GeoPyc—using …
    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Weight uniformity in tablet manufacturing - the critical role in tablet efficacy

    Newsfeeds - 22/10/2024 -
    The article discusses the critical importance of tablet weight uniformity in the tablet manufacturing process, emphasizing its role in ensuring that each tablet consistently delivers the intended dosage of key …
    assorted-pharmaceutical-tablets

    From technology selection to final drug product: material sparing approaches for asd development

    Newsfeeds - 04/10/2024 -
    Compounds with low solubility and poor bioavailability present ongoing challenges in pharmaceutical development. This webinar explores Lonza's ‘right first time’ strategy, which employs material-efficient and time-saving techniques to accelerate the …
    MEDELPHARM_CPHI_Nano_Demonstration

    MEDELPHARM and Armor Pharma collaborate for innovative formulation development at CPHI 2024

    Newsfeeds - 03/10/2024 -
    MEDELPHARM is excited to announce its participation at CPHI 2024 in Milan, exhibiting in collaboration with Armor Pharma, a leading manufacturer of pharmaceutical excipients. Together, they will present live demonstrations …
    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Tablet ejection: A systematic comparison between force, static friction, and kinetic friction

    Papers - 15/08/2024 - by Dingeman L.H. Van Der Haven, René Jensen, Maria Mikoroni, Umair Zafar, James A. Elliott, Ioannis S. Fragkopoulos
    The magnitude of frictional forces during the ejection of porous pharmaceutical tablets is crucial in determining the likelihood of tabletting defects. In this study, we conduct a systematic comparison of …
    The Increase in the Plasticity of Microcrystalline Cellulose Spheres’ When Loaded with a Plasticizer

    The increase in the plasticity of microcrystalline cellulose spheres’ when loaded with a plasticizer

    Papers - 16/07/2024 - by Artūrs Paulausks, Tetiana Kolisnyk, Valentyn Mohylyuk
    Compaction pressure can cause undesirable effects in drugs such as solid-state polymorphic transitions, fragmentation, loss of coated pellet integrity, and reduced viability and vitality of microorganisms. To mitigate these effects, …
    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Development of monoclonal antibodies in tablet form: A new approach for local delivery

    Papers - 04/07/2024 - by Julie Auffray, Hassana Hsein, Nicolas Biteau, Christophe Velours, Thierry Noel, Pierre Tchoreloff
    Among the various pharmaceutical forms, tablets provide numerous advantages, including ease of administration, cost-effectiveness in production, and enhanced stability of biomolecules. Additionally, tablets facilitate alternative routes for local delivery of …
    Image study - benefits of an optimal tabletability DC Mannitol on compression-resize

    Optimizing API load and minimizing tablet weight leveraging an innovative DC Mannitol

    Newsfeeds - 26/06/2024 -
    *INTRODUCTIONTablets with stability issues often utilize mannitol, a stable, water-soluble excipient. Direct compression is a preferred method for its simplicity and cost-effectiveness. However, directly compressible mannitol grades tend to cap …
    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Evaluation of binders in twin-screw wet granulation – Optimization of tabletability

    Papers - 25/06/2024 - by Claudia Köster, Peter Kleinebudde
    This study examined the impact of hydroxypropyl cellulose (HPC) type (HPC-SSL SFP, HPC-SSL), binder concentration (2%, 3.5%, 5%), and filler type (lactose, or calcium hydrogen phosphate (DCP)/microcrystalline cellulose (MCC)) on …
    standard tablets on blue background

    Tablet manufacturing equipment is evolving

    Newsfeeds - 14/06/2024 -
    Tablet manufacturing equipment has evolved significantly due to the demands for business efficiency. Modern tablet presses are designed to make manufacturing faster, simpler, and more efficient, achieving higher tablet yields …
    Tablet_Minitablet_vs_tablet_1

    Development of mini-tablet and multi-unit pellet systems (MUPs)

    Newsfeeds - 24/05/2024 -
    The text discusses the development and benefits of Mini-Tablet and Multi-Unit Pellet Systems (MUPS) in oral drug delivery. These advanced dosage forms offer controlled and sustained release profiles, achieved through …
    Image - Choosing the optimal dosage form for your moleculex600

    Choosing the optimal dosage form for your molecule

    Newsfeeds - 22/04/2024 -
    There are many factors to consider when choosing the right oral dosage form for your active pharmaceutical ingredient (API) leading up to clinical trials, including:- Drug profile- Ease of formulation …
    Tablet_TabInTab-vs-Multilayer_8_centered

    Modified-release formulation strategies

    Newsfeeds - 31/01/2024 -
    The increasing popularity of modified-release (MR) dosage forms is attributed to the numerous therapeutic advantages they provide for both drug developers and patients. Oral MR formulations are specifically designed to …
    KORSCH X 5

    New KORSCH X 5 advanced Single-Sided Tablet Press delivers major productivity gains

    Newsfeeds - 31/01/2024 -
    KORSCH AG has introduced the X 5 Tablet Press, an advanced single-sided rotary press that significantly enhances productivity in tablet manufacturing. Launched at Interpack 2023, the X 5 offers a …
    Sticking Detection by Repeated Compactions on a Single Tablet

    Sticking detection by repeated compactions on a single tablet

    Papers - 21/11/2023 - by James Thomas, Phuong Bui, Antonios Zavaliangos
    Tablet sticking in the context of tablet manufacturing refers to the buildup of tablet material on the punch after multiple compaction cycles. The occurrence of sticking can impact tablet weight, …
    Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability

    Examining the effect of spatial distribution of disintegrant particles on tablet disintegratability

    Papers - 09/11/2023 - by Audrey Yi Zheng, Wei Wei Huang, Li Ying Jolene Poon, Eunice Siying Wong, Paul Wan Sia Heng, Lai Wah Chan
    Objective Typically employed at low concentrations in tablets, superdisintegrants may exhibit an uneven spatial distribution within the tablet, leading to varied disintegration times. This study aimed to explore the impact …
    The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried Bacteriophages Suitable for Targeted Delivery and Controlled Release

    The development of oral solid dosage forms using the direct-compression tableting of spray-dried bacteriophages suitable for targeted delivery and controlled release

    Papers - 03/11/2023 - by Zahra Rezaie Yazdi, Mark C. Leaper, Danish J. Malik
    This study tackles the challenge of creating an affordable, patient-friendly alternative to antibiotics for gastrointestinal applications, utilizing bacteriophages. The research investigates the possibility of producing an enteric solid dosage form …
    Advanced Analysis of Disintegrating Pharmaceutical Compacts Using Deep Learning-Based Segmentation of Time-Resolved Micro-Tomography Images

    Advanced analysis of disintegrating pharmaceutical compacts Using deep learning-based segmentation of time-resolved micro-tomography images

    Papers - 22/08/2023 - by Samuel Waldner, Erwin Wendelspiess, Pascal Detampel, Christian M. Schlepütz, Jörg Huwyler, Maxim Puchkov
    Understanding the mechanism behind the disintegration of pharmaceutical tablets remains largely incomplete. Despite the crucial need to regulate the disintegration process to optimize the bioavailability of active pharmaceutical ingredients and …
    The application of Near-Infrared Spatially Resolved Spectroscopy in scope of achieving continuous real-time quality monitoring and control of tablets with challenging dimensions

    The application of near-infrared spatially resolved spectroscopy in scope of achieving continuous real-time quality monitoring and control of tablets with challenging dimensions

    Papers - 19/05/2023 - by A. De Man, J.-S. Uyttersprot, P.-F. Chavez, F. Vandenbroucke, F. Bovart, T. De Beer
    To achieve real-time release of tablets, it is imperative to monitor and control quality attributes using Process Analytical Technology tools like near-infrared spectroscopy (NIRS). The authors investigated the applicability of …