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5 types of formulation excipients

March 17, 2025
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The article discusses the importance of buffer optimization in stabilizing early development biologic products. It highlights that excipients, which are additives to buffers, play a crucial role in enhancing the long-term stability of biologics.

Key excipients include:

- Adjuvants: Boost immune response, especially in vaccines.

- Surfactants: Reduce surface tension, aiding solubilization of hydrophobic molecules.

- Amino acids: Stabilize protein charges and regulate viscosity.

- Sugars: Provide conformational stability and cryoprotection.

- Polyols: Enhance thermal stability and act as bulking agents.

The text emphasizes the need to screen various excipients for each therapeutic candidate to determine the most effective stabilizers.

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