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    Tablet_TabInTab_5

    How To achieve different release profiles and select excipients for formulation development of modified release oral solid dosage forms

    Newsfeeds - 10/07/2024 -
    Modified release oral solid dosage forms (MROSD) are specialized formulations that enable drug release over a defined period or at specific GI tract locations, improving patient adherence and reducing side …
    Tablet_Minitablet_vs_tablet_1

    Development of mini-tablet and multi-unit pellet systems (MUPs)

    Newsfeeds - 24/05/2024 -
    The text discusses the development and benefits of Mini-Tablet and Multi-Unit Pellet Systems (MUPS) in oral drug delivery. These advanced dosage forms offer controlled and sustained release profiles, achieved through …
    New Hydrophilic Matrix Tablets for the Controlled Released of Chlorzoxazone

    New hydrophilic matrix tablets for the controlled released of chlorzoxazone

    Papers - 09/05/2024 - by Andreea Creteanu, Gabriela Lisa, Cornelia Vasile, Maria-Cristina Popescu, Daniela Pamfil, Claudiu N. Lungu, Alina Diana Panainte, Gladiola Tantaru
    The controlled release of active ingredients like chlorzoxazone from matrix tablets, utilizing Kollidon®SR and chitosan, relies on both the drug's solubility in the dissolution medium and the composition of the …
    image twin screw granulation process

    A QbD guided development of a Twin-Screw Granulation process

    Newsfeeds - 12/03/2024 -
    The text discusses dry granulation techniques in the pharmaceutical industry, focusing on roller compaction and slugging, highlighting their limitations such as inferior tablet strength and reduced yield due to fine …
    White powder heap

    MEGGLE highlights role of excipient properties in alcohol-induced dose dumping AIDD

    Newsfeeds - 01/03/2024 -
    The white paper from MEGGLE emphasizes the significance of excipients in addressing alcohol-induced dose dumping (AIDD) in modified-release tablet formulations. AIDD occurs when drugs prematurely release into the bloodstream due …
    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Studying the API distribution of controlled release formulations produced via continuous twin-screw wet granulation: influence of matrix former, filler and process parameters

    Papers - 28/02/2024 - by Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
    Hydroxypropyl methylcellulose (HPMC) stands out as the favored hydrophilic matrix former in the production of controlled release formulations via continuous twin-screw wet granulation. However, previous observations have highlighted a challenge: …
    Tablet_Multilayer_15_HD.original

    Retrospective analysis of the biopharmaceutics characteristics of solid oral Modified-Release drug products

    Newsfeeds - 20/02/2024 -
    This retrospective study, spanning from 2001 to 2021, examined submissions approved by the US Food and Drug Administration (FDA) for Modified Release (MR) orally administered drugs [Extended-Release (ER) and Delayed-Release …
    Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

    Developmental strategy for swellable/erodible matrix tablet of mirabegron: quality by design approach with various geometric properties and pharmacokinetic evaluation

    Papers - 21/11/2023 - by Ji Yeon Kim, Tae Hwan Kim, Eunbin Kim, Du Hyung Choi
    Objective: This study aimed to devise a developmental strategy for matrix tablets containing mirabegron, incorporating a quality by design approach that considers geometric properties such as gel strength, erosion rate, …
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    Evaluation of in-die compression data for a deeper understanding of altered excipient properties upon temperature rise

    Papers - 28/03/2023 - by Hanna Dorothea Grumann, Stefan Klinken, Peter Kleinebudde
    The thermodynamic analysis of tablet formation involves assessing both thermal and mechanical aspects during compression. This study aimed to examine variations in force–displacement data resulting from temperature increases, serving as …
    Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

    Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading

    Papers - 01/12/2022 - by Aseel Samaro, Maarten Vergaelen, Martin Purino, Ali Tigrine, Victor R. de la Rosa, Niloofar Moazami Goudarzi, Matthieu N. Boone, Valérie Vanhoorne, Richard Hoogenboom, Chris Vervaet
    Achieving sustained release of highly dosed active pharmaceutical ingredients (APIs) from a matrix tablet poses a significant challenge. To tackle this issue, this study assessed the efficacy of thermoplastic poly(2-alkyl-2-oxazoline)s …
    Development of an amorphous based sustained release system for apremilast a selective phosphodiesterase 4 (PDE4) inhibitor

    Development of an amorphous based sustained release system for apremilast a selective phosphodiesterase 4 (PDE4) inhibitor

    Papers - 05/03/2022 - by Qiangnan Zhang, Thomas Durig, Benjamin Blass, Reza Fassihi
    Apremilast, a selective PDE4 inhibitor approved for various inflammatory disorders, is categorized as a BCS-IV drug and exists in seven polymorphic forms. This study outlines the creation of a sustained-release …
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    Starch-based controlled release matrix tablets: impact of the type of starch

    Papers - 20/10/2020 - by D. Elgaied-Lamouchi, N. Descamps, P. Lefevre, I. Rambur, J.-Y. Pierquin, F. Siepmann, J. Siepmann, S. Muschert
    Various starch types were employed in the formulation of controlled release tablets containing diprophylline through direct compression. The study explored the influence of starch's natural origin, potential chemical modifications (such …