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    Merck formulation handbook - image

    Formulation handbook from Merck

    Newsfeeds - 02/10/2025 -
    Formulating the perfect dosage form is no easy task. With so many techniques and excipients available, every decision made during development can influence the performance and success of the final …
    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Further enhancement of the sustained-release properties and stability of direct compression gel matrix bilayer tablets by controlling the particle size of HPMC and drug microencapsulation

    Papers - 06/09/2024 - by Tong Liu, Jiahui Wang, Yupeng Feng, Haoran Wang, Yunlong Xu, Tian Yin, Yu Zhang, Haibing He, Jingxin Gou, Xing Tang
    The Theophylline and Salbutamol Bilayer Sustained-release Tablets (Yi Xi Qing®), produced using wet granulation, are prone to discoloration during long-term storage, and the manufacturing process is less consistent and more …
    Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible

    Mannitol-coated hydroxypropyl methylcellulose as an alternative directly compressible controlled release excipient

    Newsfeeds - 28/08/2024 -
    One of the most common forms of controlled release technology for oral drug delivery involves dispersing an active ingredient in a hydrophilic matrix-forming polymer like hydroxypropyl methylcellulose (HPMC), which is …
    Image Fabrication and Optimization of Directly Compressible Self-Emulsifying Tablets Containing Cannabis Extract Obtained from Supercritical Carbon Dioxide Extraction

    Fabrication and optimization of directly compressible self-emulsifying tablets containing cannabis extract obtained from supercritical carbon dioxide extraction

    Newsfeeds - 15/04/2024 -
    The text discusses the challenges of low bioavailability of Tetrahydrocannabinol (THC) and Cannabidiol (CBD) in orally administered cannabis extract due to first-pass metabolism. It explores the use of a self-emulsifying …
    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Impact of dry coating lactose as a brittle excipient on multi-component blend processability

    Papers - 20/02/2024 - by Zhixing Lin, Bian Cabello, Rajesh N. Davé
    Prior research has shown the advantages of applying dry coating to finely graded microcrystalline cellulose (MCC) to facilitate direct compression (DC), a preferred method in tablet manufacturing. This process enhances …
    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Development of direct compression Acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-Aminobenzoic acid

    Papers - 07/01/2024 - by Nimmy Kumari, Parag Roy, Sukanta Roy, Chenguang Wang, Sourav Das, Noopur Pandey, Susanta Kumar Mondal, Anirbandeep Bose, Changquan Calvin Sun, Animesh Ghosh
    Pharmaceutical cocrystallization is widely applied to enhance the physicochemical attributes of Active Pharmaceutical Ingredients (APIs). However, the formulation of cocrystals with demonstrated clinical success is currently limited. The successful translation …
    Elucidating the Impact of Material Properties on Tablet Manufacturability for Binary Paracetamol Blends

    Elucidating the impact of material properties on tablet manufacturability for binary paracetamol blends

    Papers - 17/11/2023 - by Lena Mareczek, Carolin Riehl, Meike Harms, Stephan Reichl
    Objective: While the mechanical properties of paracetamol and microcrystalline cellulose (MCC) are well-documented in the literature, there is a recognized need for a more nuanced understanding of the material properties …
    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Enhancement of material attributes of poorly compressible metformin hydrochloride through coprocessing with hydroxypropyl cellulose (HPC-L) using coprecipitation (CPT)

    Papers - 06/11/2023 - by Kaushalendra Chaturvedi, Pasaorn Pongkulapa, Xiaoyi Ding, Harsh S. Shah, San Kiang, Veeran Kadajji
    Coprocessing entails integrating multiple substances to enhance the physical, chemical, mechanical, and biopharmaceutical properties of a material. It stands as a promising technique in the pharmaceutical industry, supporting both drug …
    The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried Bacteriophages Suitable for Targeted Delivery and Controlled Release

    The development of oral solid dosage forms using the direct-compression tableting of spray-dried bacteriophages suitable for targeted delivery and controlled release

    Papers - 03/11/2023 - by Zahra Rezaie Yazdi, Mark C. Leaper, Danish J. Malik
    This study tackles the challenge of creating an affordable, patient-friendly alternative to antibiotics for gastrointestinal applications, utilizing bacteriophages. The research investigates the possibility of producing an enteric solid dosage form …
    Challenges in the Transfer and Scale-Up of Mini-Tableting: Case Study with Losartan Potassium

    Challenges in the transfer and scale-up of mini-tableting: case study with Losartan Potassium

    Papers - 09/10/2023 - by Valentinë Lura, Stefan Klinken, Jörg Breitkreutz
    Mini-tablets (MTs) containing losartan potassium were developed for the treatment of the rare disease Epidermolysis Bullosa. The primary focus was on the transfer and scale-up of a direct compressible formulation …
    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Impact of material properties and process parameters on tablet quality in a continuous direct compression line

    Papers - 05/04/2023 - by Pauline H.M. Janssen, Sara Fathollahi, Bram Bekaert, Dirk Vanderroost, Timo Roelofs, Valerie Vanhoorne, Chris Vervaet, Bastiaan H.J. Dickhoff
    This paper demonstrates the influence of excipient properties on both process parameters and the ultimate tablet properties in a fully integrated continuous direct compression line. The blend properties of low-dose …
    Multivariate data analysis to evaluate commonly used compression descriptors

    Multivariate data analysis to evaluate commonly used compression descriptors

    Papers - 27/03/2023 - by Sabrina Berkenkemper, Stefan Klinken, Peter Kleinebudde
    Numerous studies have delved into material behavior through compression analyses, with a particular emphasis on compressibility, compactibility, and tabletability. In this study, an extensive multivariate data analysis was conducted using …