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    Image Hot-Melt extrusion - from theory to application in pharmaceutical formulation - where are we now

    Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation – Where Are We Now?

    Newsfeeds - 10/04/2024 -
    Hot-melt extrusion (HME) stands as a widely acknowledged and robust technology, effectively enhancing the bioavailability of poorly soluble active pharmaceutical ingredients while offering an efficient continuous manufacturing process. The twin-screw …
    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Optimizing twin-screw melt granulation: The role of overflight clearance on granulation behavior

    Papers - 25/03/2024 - by Adwait Pradhan, Brian Phillips, Fengyuan Yang, Kapish Karan, Thomas Durig, Brian Haight, Charlie Martin, Feng Zhang
    Twin-screw melt granulation (TSMG) relies on both dispersive and distributive mixing at the kneading zone to facilitate granule growth, underscoring the pivotal role played by kneading elements in TSMG. Despite …
    Yellow tablets iStock-1218616175

    Flexible granulation

    Newsfeeds - 20/02/2024 -
    The process of pharmaceutical granulation plays a pivotal role in producing solid dosage forms, directly influencing the efficacy, stability, and overall quality of the drug. Within pharmaceutical manufacturing, flexible granulation …
    MUPS KORSCH technology blog

    MUPS - the mixture is what matters

    White Papers - 06/02/2024 - by Friederike Guetter
    MUPS, or “multiple unit pellet system”, is a solid dosage form in which the granulation consists of a mixure of active, coated pellets and powder excipients. MUPS products include, for …
    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Functional and Tableting Properties of Alkali-Isolated and Phosphorylated Barnyard Millet (Echinochloa esculenta) Starch

    Papers - 22/08/2023 - by Pankaj Bhatt, Vipin Kumar, Harsh Rastogi, Mayank Kumar Malik, Raghav Dixit, Sakshi Garg, Garima Kapoor, Suruchi Singh
    The functional and tableting characteristics of barnyard millet starch (Echinochloa esculenta) were examined in its native (alkali-treated) and chemically modified (phosphorylated) forms. The grains underwent pulverization, soaking, and grinding before …
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    A REVIEW ON FORMULATION OF EFFERVESCENT TABLET

    Papers - 01/04/2023 -
    The effervescent tablets are formulated by various methods like wet granulation and dry granulation. One of the most popular ways of administering a medicament is by converting it to its …
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    An introduction to spheronization (or marumerization)

    White Papers - 14/02/2023 -
    Spheronization (or marumerization) is the process where extrudates (the output from an extruder) are shaped into small rounded or spherical granules. In practice these usually vary in size from 0.4 …
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    Charge reduction assisted production of diminutive fluid bed granules for high drug load minitablets

    Papers - 25/07/2022 - by Shang Jun Loo, Paul Wan Sia Heng, Lai Wah Chan
    Micronized drug powders are often impractical for use as tableting feed to create minitablets due to their cohesiveness and poor flow properties. The addition of fumed silica (fSi) within an …
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    Assess the impact of your granulation process parameters with the STYL'One Evo

    Bulletins - 01/03/2022 - by Sixtine Caquant, Adrien Pelloux
    Powder granulation is commonly used in the pharmaceutical industry to improve flowability and compactibility of powders. In this case our customer wanted to develop a new directcompression grade of excipient …
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    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Papers - 01/06/2020 - by V. Vanhoorne, R. Almey, T. De Beer, C. Vervaet
    In this present study, we explored whether the moisture-mediated polymorphic transition from δ- to β-mannitol observed during twin screw granulation (TSG) could occur in formulations with a high drug load. …
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    Influence of Formulation Parameters on Redispersibility of Naproxen Nanoparticles from Granules Produced in a Fluidized Bed Process

    Papers - 16/04/2020 - by Martin Wewers, Stefan Czyz, Jan Henrik Finke, Edgar John, Bernard Van Eerdenbrugh, Michael Juhnke, Heike Bunjes, Arno Kwade
    Reducing the particle size of active pharmaceutical ingredients is an efficient strategy for addressing challenges related to poor aqueous solubility. To enhance stability and patient convenience, nanosuspensions are often converted …
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    Powders flowability assessment in granular compaction: What about the consistency of Hausner ratio?

    Papers - 01/09/2019 - by A. Saker, M.-G. Cares-Pacheco, P. Marchal, V. Falk
    This study evaluates powder flowability during granular compaction under free surface conditions, utilizing the Hausner ratio (HR) as the flowability index. Various pharmaceutical and food powders were scrutinized using three …