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    Advancing solid fraction analysis: Testing laser triangulation as an at-line technique

    Advancing solid fraction analysis: Testing laser triangulation as an at-line technique

    Papers - 01/06/2026 - by Camille Adler, Bindhu Gururajan, Vincent Rogue, Jan Lenz, Lizbeth Martinez
    Roller compaction is a dry granulation technique used to improve the flow properties of pharmaceutical materials when direct tablet compression is not feasible. It is often preferred to wet granulation …
    Scaling For Commercialization- Considerations For Large-Scale API Production - image

    Scaling for commercialization: considerations for large-scale API production

    Newsfeed - 17/12/2025 -
    As drug development programs move from clinical scale to commercial manufacturing, scaling up active pharmaceutical ingredient (API) production introduces significant challenges that go beyond simply increasing batch sizes. The article …
    Big batch of tablets

    Pilot plant prep

    Newsfeed - 09/10/2025 -
    In the article "Pilot Plant Prep" from Nutritional Outlook, Fred Murray, President of KORSCH America, emphasizes the critical importance of aligning pilot-scale tablet presses with full-scale production machines. He warns …
    Capture Virtual Pharma Expo

    Predictive tablet press scale-up from R&D to production with STYL’One Evo Compaction Simulator

    Newsfeed - 26/09/2025 -
    At the Virtual Pharma Expo 2025, KORSCH America showcased the STYL’One Evo Compaction Simulator, a cutting-edge solution that helps pharmaceutical formulators predict high-speed tablet performance and accelerate scale-up from lab …
    Evaluation of Time-Dependent Deformation Behavior of Pharmaceutical Excipients in the Tableting Process

    Evaluation of time-dependent deformation behavior of pharmaceutical excipients in the tableting process

    Papers - 22/03/2025 - by Daisuke Mizunaga, Satoru Watano
    Tableting is a crucial process in pharmaceutical manufacturing that directly impacts product quality. Maintaining consistent quality from the research and development phase to full-scale production is essential during scale-up. In …
    Partnership with knowledge gain - on both sides

    Partnership with knowledge gain – on both sides

    Newsfeed - 26/11/2024 -
    The partnership between KORSCH, MEDELPHARM, and the Institute of Particle Technology (iPAT) at the Technical University of Braunschweig focuses on advancing tableting technologies and understanding powder behavior through collaborative research. …
    Scaling for Commercialization - Considerations for large-scale API Production

    Scaling for commercialization: considerations for large-scale API production

    Newsfeed - 04/11/2024 -
    Scaling up from clinical development to larger batch sizes involves numerous challenges and complexities that must be addressed to ensure successful outcomes. Key factors such as risk mitigation, production scalability, …
    Defects in tablet production KORSCH

    Understanding the powder compression phase - and avoiding tablet defects

    Whitepapers - 14/10/2024 -
    From Vincent Mazel, 19.06.2024The tableting process looks simple, but is complex and irreversible: the University of Bordeaux is learning together with the tableting specialists.Expert in physics and mechanics, highly regarded …
    STYL'One Evo scientist

    STYL’One Evo R&D – Scale-up and production support

    Newsfeed - 10/07/2024 -
    The STYL’One Evo is a versatile, advanced R&D tablet press designed for use from early API characterization to production support. It is easy to use, clean, and maintain, featuring intuitive …
    Image The Effect of Formulation Variables on the Manufacturability of Clopidogrel Tablets via Fluidized Hot-Melt Granulation

    The effect of formulation variables on the manufacturability of clopidogrel tablets via fluidized hot-melt granulation

    Newsfeed - 16/05/2024 -
    This study investigates the challenges faced by solid pharmaceutical formulations containing class II active pharmaceutical ingredients (APIs) due to limited solubility, which affects their behavior in the body. Computational tools …
    no-image

    Modeling of STYL'One Evolution correction factors for multicomponent mixtures scaling-up to roller compaction

    Papers - 11/04/2024 - by Fabia Arpago, Agostino Dall'Ara
    Roll compaction (RC) stands as a cost-efficient dry granulation technique extensively utilized in the pharmaceutical sector. In the initial stages of formulation development, particularly when resources are constrained, the ability …
    Development of a Semi-Mechanistic Modeling Framework for Wet Bead Milling of Pharmaceutical Nanosuspensions

    Development of a semi-mechanistic modeling framework for wet bead milling of pharmaceutical nanosuspensions

    Papers - 13/03/2024 - by Donald J. Clancy, Gulenay Guner, Sayantan Chattoraj, Helen Yao, M. Connor Faith, Zahra Salahshoor, Kailey N. Martin, Ecevit Bilgili
    The objective of this study was to create a practical semi-mechanistic modeling framework for forecasting particle size changes during the wet bead milling of pharmaceutical nanosuspensions across various process conditions …