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    Mechanical properties of tablets: direct compression vs. twin-screw melt granulation with PEG 8000

    Mechanical properties of tablets: direct compression vs. twin-screw melt granulation with PEG 8000

    Papers - 01/05/2024 - by Zoltán Márk Horváth, Kirils Kukuls, Liga Petersone, Valentyn Mohylyuk
    Here's a revised version of your text: Replacing batch wet granulation with a continuous, solvent-free process using a twin-screw melt extruder is becoming increasingly popular. Although PEG 8000 is a …
    Twin-Screw Melt Granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Twin-screw melt granulation with PEG 8000: effect of binder particle size and processing temperature on the granule and tablet properties

    Papers - 18/03/2024 - by Zoltán Márk Horváth, Liga Lauberte, Valentyn Mohylyuk
    The aim of this study was to investigate the effect of PEG 8000 particle size and twin-screw melt granulation temperature on the properties of resultant MCC-CaHPO4 granules and their tablets.
    image twin screw granulation process

    A QbD guided development of a Twin-Screw Granulation process

    Newsfeeds - 12/03/2024 -
    The text discusses dry granulation techniques in the pharmaceutical industry, focusing on roller compaction and slugging, highlighting their limitations such as inferior tablet strength and reduced yield due to fine …
    Studying the API Distribution of Controlled Release Formulations Produced via Continuous Twin-Screw Wet Granulation: Influence of Matrix Former, Filler and Process Parameters

    Studying the API distribution of controlled release formulations produced via continuous twin-screw wet granulation: influence of matrix former, filler and process parameters

    Papers - 28/02/2024 - by Phaedra Denduyver, Chris Vervaet, Valérie Vanhoorne
    Hydroxypropyl methylcellulose (HPMC) stands out as the favored hydrophilic matrix former in the production of controlled release formulations via continuous twin-screw wet granulation. However, previous observations have highlighted a challenge: …
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    Use of Polyvinyl Alcohol as an effective binder in continuous Twin-Screw Granulation

    Papers - 01/02/2024 - by Gudrun Birk, Anja-Nadine Knüttel, Almut von der Brelie
    Granulation of powder blends is a frequently employed method in pharmaceutical formulations when there are issues with flowability, compactability, or uniformity in terms of the active pharmaceutical ingredient (API) content. …
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    Scale-up in Twin-screw wet granulation: Impact of formulation properties

    Papers - 27/10/2023 - by Marcel Franke, Thomas Riedel, Robin Meier, Carsten Schmidt, Peter Kleinebudde
    This study aimed to explore the responsiveness of various drug formulations to differences in process parameters based on previously established scale-up strategies. Three distinct formulations were employed for scale-up experiments, …
    TPLS as predictive platform for twin-screw wet granulation process and formulation development

    TPLS as predictive platform for twin-screw wet granulation process and formulation development

    Papers - 08/06/2021 - by A. Ryckaert, D. Van Hauwermeiren, J. Dhondt, A. De Man, A. Funke, D. Djuric, C. Vervaet, I. Nopens, T. De Beer
    In recent years, there has been a growing interest in continuous manufacturing techniques, such as twin-screw wet granulation. However, our comprehension of how the combination of raw material properties and …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 10/03/2021 - by Lise Vandevivere
    The investigation focused on evaluating the appropriateness of pharmaceutical binders for continuous twin-screw wet granulation, reflecting the pharmaceutical industry's shift from batch to continuous manufacturing. A comparison was conducted between …
    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

    Papers - 03/02/2021 - by Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne
    The appropriateness of pharmaceutical binders for continuous twin-screw wet granulation was examined, aligning with the pharmaceutical industry's transition from batch to continuous manufacturing. A scientific approach to binder selection is …
    Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

    Melt granulation: A comparison of granules produced via high-shear mixing and twin-screw granulation

    Papers - 14/10/2020 - by Kristina E. Steffens, Marvin B. Brenner, Michael U. Hartig, Marius Monschke, Karl G. Wagner
    Melt granules containing DI-CAFOS® A12 and 15% (w/w) Kolliphor® P407 were produced using a twin-screw granulator (TSG) under five different conditions (varied screw speed and throughput). These were then compared …
    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

    Papers - 30/07/2020 - by L. Vandevivere, P. Denduyver, C. Portier, O. Häusler, T. De Beer, C. Vervaet, V. Vanhoorne
    The impact of various binders on the quality of granules produced through continuous twin-screw wet granulation was investigated. Anhydrous dicalcium phosphate served as a poorly soluble filler, and binders were …
    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

    Papers - 01/06/2020 - by V. Vanhoorne, R. Almey, T. De Beer, C. Vervaet
    In this present study, we explored whether the moisture-mediated polymorphic transition from δ- to β-mannitol observed during twin screw granulation (TSG) could occur in formulations with a high drug load. …