Webinar on demand - solid form screening of active pharmaceutical Ingredients

June 03, 2024

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Solid form services serve as the crucial link between the development of drug substances and drug products for New Chemical Entities (NCEs). Early screening, selection, and isolation of the primary polymorph can prevent additional expenses and delays caused by the unexpected emergence of stable polymorphs later in the development process. Conversely, solid form screening of salts and cocrystals can yield a stable crystalline form capable of enhancing the solubility of poorly soluble drugs, thereby improving bioavailability.

In this webinar, Lonza explores the vital role of solid form services in meeting the accelerated timelines of drug development. Additionally, we present examples of efficient workflows for rapid and comprehensive solid form screening. A case study delves into the polymorph screening of a late-stage API, with a focus on monotropic versus enantiotropic polymorphs. We also highlight the development of the crystallization process for the primary form.

Key Learning Objectives:

- Understanding the significance of solid form screening and form selection in pharmaceutical development

- Exploring the process of screening monotropic and enantiotropic polymorphs

- Appreciating the design considerations for establishing robust crystallization processes for primary forms